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公开(公告)号：US20050191352A1
公开(公告)日：2005-09-01
申请号：US11056035
申请日：2005-02-11
申请人： Geoffrey Hayes , Vincenzo Martinelli , Hassan Mohammad , Derek Prater , Harjit Tamber , Malcolm Walden , Steve Whitelock
发明人： Geoffrey Hayes , Vincenzo Martinelli , Hassan Mohammad , Derek Prater , Harjit Tamber , Malcolm Walden , Steve Whitelock
CPC分类号： A61K9/1635 , A61K9/16 , A61K9/1694 , Y10T428/2982
摘要： The invention relates to a process for preparing a controlled release pharmaceutical extrudate using a melt extruder, wherein the melt extruder comprises a die-head supporting a die-plate in which orifices are located, and a cutter adjacent to the die-head, and wherein the cutter cuts the extruded mix as it emerges under pressure and still molten or softened from the orifices of the die-plate.
摘要翻译： 本发明涉及一种使用熔体挤出机制备控释药物挤出物的方法，其中熔融挤出机包括支撑孔的模头和与模头相邻的切割器，其中 挤出的混合物在压力下出现时会切割挤出的混合物，并仍然从模板的孔口熔化或软化。
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公开(公告)号：US20070259045A1
公开(公告)日：2007-11-08
申请号：US11574778
申请日：2006-01-27
申请人： Richard Mannion , William Mckenna , Edward O'Donnell , Helen Danagher , Geoffrey Hayes , Hassan Mohammad , Derek Prater , Harjit Tamber , Walden Malcolm , Steve Whitelock , Wolfgang Fleischer , Udo Hahn , Christof Spitzley , Christian Leuner
发明人： Richard Mannion , William Mckenna , Edward O'Donnell , Helen Danagher , Geoffrey Hayes , Hassan Mohammad , Derek Prater , Harjit Tamber , Walden Malcolm , Steve Whitelock , Wolfgang Fleischer , Udo Hahn , Christof Spitzley , Christian Leuner
IPC分类号： A61K9/00 , A61K31/44 , A61P29/00 , C07D471/00
CPC分类号： A61K9/1652 , A61K9/16 , A61K9/20 , A61K9/2054 , A61K9/2077 , A61K31/485 , A61K45/06
摘要： Disclosed in certain embodiments is a controlled release dosage form comprising a matrix comprising a pharmaceutically acceptable salt of an opioid analgesic in a controlled release material; wherein less than 25% of the opioid salt is released after 1 hour of in-vitro dissolution of the dosage form in 900 ml of Simulated Gastric Fluid with 20% ethanol using a USP Apparatus I (basket) apparatus at 100 rpm at 37 degrees C.°.
摘要翻译： 在某些实施方案中公开了控释剂型，其包含在控释材料中包含阿片样物质镇痛药的药学上可接受的盐的基质; 其中小于25％的阿片样物质盐在使用USP装置I（筐）装置的体外溶解于900ml含20％乙醇的模拟胃液1小时后以100rpm在37℃下释放 。
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公开(公告)号：US20120093929A1
公开(公告)日：2012-04-19
申请号：US12991338
申请日：2009-05-05
申请人： Alexander Oksche , Kevin J. Smith , Derek Prater , Malcolm Walden , Will Heath , Bernard Kennedy , Vanessa Addison , Hassan Mohammad
发明人： Alexander Oksche , Kevin J. Smith , Derek Prater , Malcolm Walden , Will Heath , Bernard Kennedy , Vanessa Addison , Hassan Mohammad
IPC分类号： A61K9/00 , A61K31/135 , A61K31/216 , A61K31/137 , A61K31/445 , A61K38/08 , A61P25/04 , A61K31/439 , A61K31/24 , B82Y5/00
CPC分类号： A61K9/70 , A61K9/7084
摘要： The present invention relates to a composition, comprising (i) a matrix made of polymeric nanofibers, and (ii) an opioid agonist within the matrix.
摘要翻译： 本发明涉及一种组合物，其包含（i）由聚合物纳米纤维制成的基质，和（ii）所述基质内的阿片样物质激动剂。
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公开(公告)号：US09782359B2
公开(公告)日：2017-10-10
申请号：US12991338
申请日：2009-05-05
申请人： Alexander Oksche , Kevin J. Smith , Derek Prater , Malcolm Walden , Will Heath , Bernard Kennedy , Vanessa Addison
发明人： Alexander Oksche , Kevin J. Smith , Derek Prater , Malcolm Walden , Will Heath , Bernard Kennedy , Vanessa Addison , Hassan Mohammad
IPC分类号： A61K9/70
CPC分类号： A61K9/70 , A61K9/7084
摘要： The present invention relates to a composition, comprising (i) a matrix made of polymeric nanofibers, and (ii) an opioid agonist within the matrix.
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公开(公告)号：US20060269603A1
公开(公告)日：2006-11-30
申请号：US11435015
申请日：2006-05-16
申请人： Ronald Brown Miller , Stewart Leslie , Sandra Malkowska , Kevin Smith , Walter Wimmer , Horst Winkler , Udo Hahn , Derek Prater
发明人： Ronald Brown Miller , Stewart Leslie , Sandra Malkowska , Kevin Smith , Walter Wimmer , Horst Winkler , Udo Hahn , Derek Prater
IPC分类号： A61K9/22
CPC分类号： A61K9/1617 , A61K9/1641 , A61K9/1652 , A61K9/2013 , A61K9/2031 , A61K9/2054 , A61K9/2072 , A61K9/2077 , A61K9/2095 , A61K9/2866 , A61K31/135 , A61K31/137 , A61K31/485
摘要： A controlled release preparation for oral administration contains tramadol, or a pharmaceutically acceptable salt thereof, as active ingredient.
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公开(公告)号：US07846476B2
公开(公告)日：2010-12-07
申请号：US10476409
申请日：2002-05-02
申请人： Benjamin Oshlack , Curtis Wright , Derek Prater
发明人： Benjamin Oshlack , Curtis Wright , Derek Prater
CPC分类号： A61K9/1617 , A61K9/0004 , A61K9/1635 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/485
摘要： The invention is directed to sustained release formulations containing oxycodone or a pharmaceutically acceptable salt thereof which provide a mean C24/Cmax oxycodone ratio of 0.6 to 1.0 or 0.7 to 1 after oral administration at steady state to patients and methods thereof.
摘要翻译： 本发明涉及含有羟考酮或其药学上可接受的盐的持续释放制剂，其在稳定状态下口服给予患者及其方法时，其平均C24 / Cmax羟考酮比例为0.6至1.0或0.7至1。
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公开(公告)号：US20070071820A1
公开(公告)日：2007-03-29
申请号：US11603766
申请日：2006-11-22
申请人： Derek Prater , Mohammed Hassan , Christopher Bland
发明人： Derek Prater , Mohammed Hassan , Christopher Bland
IPC分类号： A61K9/26
CPC分类号： A61K9/5073 , A61K9/1652 , A61K9/5026 , A61K9/5036
摘要： Delivery of a drug is controlled to impart a delay before release after administration by formulating the drug with a disruption agent to provide a core, and coating the core with a regulatory membrane comprising a water-soluble gel-forming polymer and a water-insoluble film-forming polymer.
摘要翻译： 控制药物的输送以通过配制药物与给药后给予延迟以提供核心，并用包含水溶性凝胶形成聚合物和水不溶性膜的调节膜包被核心 形成聚合物。
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公开(公告)号：US20110104214A1
公开(公告)日：2011-05-05
申请号：US12917148
申请日：2010-11-01
申请人： Benjamin Oshlack , Curtis Wright , Derek Prater
发明人： Benjamin Oshlack , Curtis Wright , Derek Prater
IPC分类号： A61K31/485 , A61K9/00 , A61P25/04
CPC分类号： A61K31/485 , A61K9/0004 , A61K9/1617 , A61K9/1635 , A61K9/2018 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2086
摘要： The invention is directed to sustained release formulations containing oxycodone or a pharmaceutically acceptable salt thereof which provide a mean C24/Cmax oxycodone ratio of 0.6 to 1.0 or 0.7 to 1 after oral administration at steady state to patients and methods thereof.
摘要翻译： 本发明涉及含有羟考酮或其药学上可接受的盐的持续释放制剂，其在稳定状态下口服给予患者及其方法时，其平均C24 / Cmax羟考酮比例为0.6至1.0或0.7至1。
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