公开(公告)号：US20090110694A1

公开(公告)日：2009-04-30

申请号：US12225456

申请日：2007-03-22

申请人： Geoffrey Smith ,  An-Jung Chen

发明人： Geoffrey Smith ,  An-Jung Chen

IPC分类号： A61K39/12 ,  C12N7/00 ,  C12N15/11 ,  C07K2/00 ,  A61K38/02 ,  A61K31/7088 ,  C12N5/06

CPC分类号： C12N15/86 ,  A61K39/00 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/24122 ,  C12N2710/24143 ,  C12N2710/24161 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/476 ,  Y02A50/487

摘要： A recombinant poxvirus lacking a functional gene corresponding to BI4R in the WR strain of VACV for use as a medicament especially as a vaccine against a disease caused by a poxvirus or another pathogenic agent or for use as a medicament against a disease associated with aberrant cells. An isolated nucleotide or polypeptide encoding a poxvirus sequence corresponding to the sequence of B14 in the WR strain of VACV especially for use as a medicament against undesirable inflammation, immune activation or NF-κB activation. Related compositions and methods.

摘要翻译： 在VACV的WR菌株中缺乏与BI4R相对应的功能基因的重组痘病毒用作药物，特别是作为针对由痘病毒或另一病原体引起的疾病的疫苗或用作抗异常细胞相关疾病的药物。 编码对应于VACV的WR菌株中的B14序列的痘病毒序列的分离的核苷酸或多肽，特别是用作抗不需要的炎症，免疫激活或NF-κB活化的药物。 相关的组合物和方法。