公开(公告)号：US5109862A

公开(公告)日：1992-05-05

申请号：US658505

申请日：1991-02-21

申请人： George J. Kelen ,  Raphael Henkin

发明人： George J. Kelen ,  Raphael Henkin

IPC分类号： A61B5/0432 ,  G06F17/00

CPC分类号： A61B5/0432 ,  A61B5/7253 ,  A61B5/7257

摘要： A frequency domain signal processing and analysis method and apparatus displays, plots and makes measurements upon electrocardiographic signals (ECG) recorded from the body surface. Both the graphic plots and the numeric parameters measured reveal abnormalities of electrical conduction within the heart thought to be important in the identification of patients at risk of serious disturbances of heart rhythm including sudden death. The invention employs Fourier analysis of short overlapping segments of ECG signal to create a three dimensional map ("spectrocardiogram") whose axes are time, fequency and power thus disclosing changes in the frequency content of the ECG signal over short intervals of time. In additoin to the Fourier analysis itself, the method and apparatus provides a wide choice of user-selectable signal pre-processing, post-processing, display and plotting options as well as performing custom mathematical computations upon the Fourier spectra to distinguish and quantify visually apparent differences between normal and abnormal spectrocardiograms.

摘要翻译： 频域信号处理和分析方法和装置显示，绘图并对从身体表面记录的心电图信号（ECG）进行测量。 图形图和测量的数值参数都揭示了心脏内电传导的异常，认为在识别患有严重心律紊乱（包括猝死）风险的患者中是重要的。 本发明使用ECG信号的短重叠段的傅里叶分析来创建其轴是时间，频率和功率的三维映射（“光谱仪”），从而公开了在短时间间隔内ECG信号的频率含量的变化。 此外，傅里叶分析本身，该方法和装置提供了用户可选择的信号预处理，后处理，显示和绘图选项的广泛选择，以及在傅立叶光谱上执行定制数学计算以区分和量化视觉表观 正常和异常光谱之间的差异。

公开(公告)号：US5092341A

公开(公告)日：1992-03-03

申请号：US539581

申请日：1990-06-18

申请人： George J. Kelen

发明人： George J. Kelen

IPC分类号： A61B5/0452 ,  G06F17/00

CPC分类号： A61B5/0464 ,  A61B5/7253 ,  A61B5/7239 ,  A61B5/7257

摘要： Frequency domain ECG signal processing systems and methods plot spectral maps and compute statistical parameters from surface electrocardiographic signals, which plots and parameters reveal abnormalities of electrical conduction within the hearts of patients at risk of ventricular tachycardia. Fourier analysis of short overlapping time segments of QRS ECG signal are used to create three dimensional spectral maps disclosing changes in the frequency spectral content of the ECG signal over the whole QRS region. Correlations and statistical evaluations of the spectral content between QRS time segment pairs quantify the spectral turbulence of the ECG and distinguish those at risk from ventricular tachyarrhythmias.

公开(公告)号：US4883065A

公开(公告)日：1989-11-28

申请号：US271903

申请日：1988-11-15

申请人： George J. Kelen

发明人： George J. Kelen

IPC分类号： A61B5/0436 ,  A61B5/0452 ,  G06F17/00

CPC分类号： A61B5/04525 ,  A61B5/04365

摘要： A system for detection, measurement, analysis and plotting of electrocardiographic signals with amplitudes ranging down to one microvolt (micropotentials) employing long term ambulatory (Holter) recordings. Multi-channel electrocardiograms are recorded on a Holter recorder that inscribes calibration pulses at the beginning of each tape. The tape is played back at high speed on a scanner which uses the recorded calibration pulses to automatically calibrate the signal gains for each signal channel. The played back signals are digitized at sufficient resolution and sampling rate to permit analysis of micropotentials. The digitized raw data is stored in a permanent computer file available for multiple further analyses. A template heart beat is designated and the raw data file is signal averaged to reduce random noise. The averaged beat thus produced is permanently stored, and analyzed using a variety of operator selected standard signal processing techniques to reveal and evaluate micropotential signals of clinical significance.

摘要翻译： 用于使用长期动态（Holter）记录的幅度范围低至一微伏（微量）的心电图信号的检测，测量，分析和绘图系统。 多通道心电图记录在Holter记录仪上，该记录仪在每个磁带的开头刻有校正脉冲。 磁带在扫描仪上以高速播放，使用记录的校准脉冲自动校准每个信号通道的信号增益。 回放信号以足够的分辨率和采样率进行数字化，以便分析微量元素。 数字化的原始数据存储在可用于多个进一步分析的永久计算机文件中。 指定模板心跳，并将原始数据文件进行信号平均以减少随机噪声。 这样产生的平均搏动是永久存储的，并使用各种操作者选择的标准信号处理技术进行分析，以显示和评估具有临床意义的微电位信号。

公开(公告)号：US4532934A

公开(公告)日：1985-08-06

申请号：US495154

申请日：1983-05-17

申请人： George J. Kelen

发明人： George J. Kelen

IPC分类号： A61B5/0436 ,  A61N1/37 ,  A61B5/04

CPC分类号： A61N1/37 ,  A61B5/04365 ,  A61B5/7203 ,  A61B5/7239 ,  A61N1/3718

摘要： A system for ambulatory monitoring and subsequent analysis and evaluation of pacemaker performance includes a recorder module which detects pacemaker spikes and in response to each spike generates a signal having a waveform compatible with commericially-available ambulatory ECG recorders, to permit ECG signals to be recorded in one channel of the recorder while simultaneously the pacemaker spike signals are recorded in another channel. The magnetic tape on which the signals are recorded is played back at 120 times the recording speed, typically, on a commercially-available playback analyzer which presents the pacemaker and ECG signals as separate outputs. The system further includes an analysis module connected to the playback unit and receiving from it the ECG signals and the pacemaker spike signals. The analysis module has counters which accumulate the number of paced beats and of fusion beats. The analysis module also includes circuits for sensing manifestations of pacemaker malfunction. When malfunction is sensed, the analysis module reduces the playback speed to facilitate study by an operator and activates a visual alarm. The conditions sensed include: failure-to-sense, failure-to-capture, and abnormal bradycardia.

摘要翻译： 用于行走监测和随后的起搏器性能分析和评估的系统包括检测起搏器尖峰的记录器模块，并且响应于每个尖峰产生具有与市售可行动态ECG记录器兼容的波形的信号，以允许将ECG信号记录在 记录器的一个通道同时将起搏器尖峰信号记录在另一个通道中。 记录信号的磁带通常在商业上可以将起搏器和ECG信号作为单独的输出的再现分析器以120倍的记录速度回放。 该系统还包括连接到播放单元并从其接收ECG信号和起搏器尖峰信号的分析模块。 分析模块具有积累节拍次数和融合节拍数的计数器。 分析模块还包括用于感测起搏器故障表现的电路。 当检测到故障时，分析模块会降低播放速度，以便操作人员进行研究并启动视觉报警。 检测到的病情包括：无效，无法捕获和异常心动过缓。

公开(公告)号：US4291703A

公开(公告)日：1981-09-29

申请号：US106692

申请日：1979-12-26

申请人： George J. Kelen

发明人： George J. Kelen

IPC分类号： A61B5/0436 ,  A61N1/37 ,  A61B5/04

CPC分类号： A61N1/37 ,  A61B5/04365 ,  A61B5/7203 ,  A61B5/7207 ,  A61B5/7239 ,  A61N1/3718

摘要： A recorder for monitoring the operation of a cardiac pacemaker and the response of the patient to the pacemaker includes a recorder module which receives a composite signal including an ECG signal, a pacemaker spike having a frequency spectrum that lies substantially at frequencies greater than the frequency band required to pass the ECG signal, and further includes artifact noise within the frequency spectrum of the pacemaker spike. The recorder module distinguishes the pacemaker spike from the artifact noise and upon recognizing the pacemaker spike, the recorder module produces a distinctive synthesized signal whose frequency spectrum lies substantially within the frequency band required to pass the ECG signal so that the synthesized signal will pass through the pre-emphasis filter that is used to reject artifact noise and will then be recorded.

摘要翻译： 用于监测心脏起搏器的操作的记录器和患者对起搏器的响应包括记录器模块，其接收包括ECG信号的复合信号，起搏器尖峰具有基本上位于大于频带的频率的频谱 需要通过ECG信号，并且还包括起搏器尖峰频谱内的伪影噪声。 记录器模块将起搏器峰值与伪影噪声区分开，并且在识别起搏器尖峰时，记录器模块产生一个独特的合成信号，其频谱基本上位于通过ECG信号所需的频带内，使得合成信号将通过 用于拒绝伪像噪声的预加重滤波器，然后将被记录。