公开(公告)号：US20080086050A1

公开(公告)日：2008-04-10

申请号：US11868552

申请日：2007-10-08

申请人： George J. Misic ,  Alan D. Hirschman

发明人： George J. Misic ,  Alan D. Hirschman

IPC分类号： A61B5/05

CPC分类号： A61B5/055 ,  A61B18/12 ,  A61B2018/0016 ,  A61B2018/183 ,  A61B2090/374 ,  G01R33/34084 ,  G01R33/4804

摘要： Hyperthermia has been applied by, for example, separate ultrasound transducers, RF or microwave transmitters and heated fluids. Imaging by separate MRI imaging coils is usually used to view the anatomical region under treatment. Separate temperature probes (needles, catheters) are often used to monitor tissue temperature. Control of the temperature profile required for effective hyperthermia treatment is usually done by trial and error, involving a human operator. The present invention combines all of these capabilities into a single device, which is MRI compatible and safe. It also allows for automatic control of the RF energy to achieve a prescribed tissue hyperthermia.

摘要翻译： 已经通过例如单独的超声换能器，RF或微波发射器和加热流体应用了热疗。 单独MRI成像线圈的成像通常用于观察治疗前的解剖区域。 单独的温度探针（针，导管）通常用于监测组织温度。 控制有效热疗治疗所需的温度曲线通常是通过试验和错误的方式进行的，涉及人类操作者。 本发明将所有这些功能组合成单个设备，其是MRI兼容且安全的。 它还允许自动控制RF能量以实现规定的组织热疗。

公开(公告)号：US08581590B2

公开(公告)日：2013-11-12

申请号：US13128361

申请日：2009-11-12

申请人： George J. Misic ,  Robert J. McKenney

发明人： George J. Misic ,  Robert J. McKenney

IPC分类号： G01V3/00

CPC分类号： G01R33/341 ,  G01R33/34084 ,  G01R33/3678

摘要： An intracavity probe for use with an MR system allows images and spectra of internal anatomical structures to be obtained. The intracavity probe houses within its balloon-type enclosure a single-element quadrature coil sensitive to both the vertical and horizontal components of the MR signal. The quadrature coil by means of its output line is designed to plug into a dedicated interface device with which to interface the quadrature coil with the MR system. Drive capacitors within the coil in conjunction with the electrical length of the output line and phase shifting networks within the interface device enable complete decoupling of the quadrature coil from the transmit fields generated by the MR system. Preamplifier, power splitting and combining networks within the interface device process voltage signals representative of the horizontal and vertical components of the MR signal and enable them to be conveyed to the input port(s) of the MR system.

摘要翻译： 用于MR系统的腔内探针允许获得内部解剖结构的图像和光谱。 腔内探头在其气球型外壳内容纳有对MR信号的垂直和水平分量敏感的单元正交线圈。 通过其输出线的正交线圈被设计成插入专用接口装置中，以使正交线圈与MR系统接口。 线圈内的驱动电容与输出线的电气长度以及接口装置内的相移网络之间能够使正交线圈与由MR系统产生的发射场完全解耦。 接口设备内的前置放大器，功率分配和组合网络处理代表MR信号的水平和垂直分量的电压信号，并使其能够被传送到MR系统的输入端口。

公开(公告)号：US07747310B2

公开(公告)日：2010-06-29

申请号：US10483945

申请日：2003-03-13

申请人： George J. Misic ,  Edward J. Rhinehart

发明人： George J. Misic ,  Edward J. Rhinehart

IPC分类号： A61B5/055

CPC分类号： G01R33/285 ,  A61B5/055 ,  G01R33/34084 ,  G01R33/3628

摘要： An MR system features an intracavity probe and associated interface device. The probe includes a shaft, a balloon at one end thereof, and a coil loop within the balloon. The loop has two drive capacitors and a tuning capacitor, all of which in series. A junction node between the drive capacitors serves as a ground for electrically balancing the loop. Diametrically opposite the node, the tuning capacitor enables the loop to resonate at the operating frequency of the MR system. The interface allows the MR system to couple the loop to a port of the MR system during a receive cycle thereof and decouple it from the port during a transmit cycle thereof. With its balloon inserted and inflated within a cavity of a patient, the probe allows the MR system to generate images and/or spectra of the region of interest using the MR signals received by the loop.

摘要翻译： MR系统具有腔内探针和相关接口装置。 探针包括轴，其一端处的气囊和气囊内的线圈环。 该回路具有两个串联的驱动电容器和一个调谐电容器。 驱动电容器之间的结节点用作电平衡环路的接地。 与节点完全相反，调谐电容使得环路在MR系统的工作频率下谐振。 该接口允许MR系统在其接收周期期间将环路耦合到MR系统的端口，并在其发射周期期间将其与端口分离。 通过将气球插入并充气到患者的腔内，探针允许MR系统使用循环接收的MR信号来产生感兴趣区域的图像和/或光谱。

公开(公告)号：US07084629B2

公开(公告)日：2006-08-01

申请号：US10723428

申请日：2003-11-27

申请人： William J. Monski, Jr. ,  Fahad Alradady ,  George J. Misic

发明人： William J. Monski, Jr. ,  Fahad Alradady ,  George J. Misic

IPC分类号： G01V3/00

CPC分类号： G01R33/34046

摘要： A birdcage coil for use with a magnetic resonance (MR) system comprises a first ring at one thereof, a second ring at the other end thereof, and a plurality of rods electrically interconnecting the first and second rings. The first ring is electrically conductive and has a first diameter. The second ring is electrically conductive and has a second diameter. The rods and first and second rings are configured to form about the birdcage coil a plurality of partially-overlapped primary resonant substructures. Each primary resonant substructure includes two of the rods and the corresponding sections of the first and second rings interconnecting them.

摘要翻译： 用于磁共振（MR）系统的鸟笼线圈包括其一端的第一环，另一端的第二环，以及将第一和第二环电连接的多个杆。 第一环是导电的并且具有第一直径。 第二环是导电的并且具有第二直径。 杆和第一和第二环被配置成围绕鸟笼线圈形成多个部分重叠的初级谐振子结构。 每个初级谐振子结构包括两个杆，并且第一和第二环的相应部分互相连接。

公开(公告)号：US5355087A

公开(公告)日：1994-10-11

申请号：US637658

申请日：1991-02-11

申请人： Theodore C. Claiborne ,  George J. Misic ,  Thomas R. Welch ,  Edward J. Rhinehart

发明人： Theodore C. Claiborne ,  George J. Misic ,  Thomas R. Welch ,  Edward J. Rhinehart

IPC分类号： G01R33/32 ,  A61B5/055 ,  A61F2/958 ,  G01R33/28 ,  G01R33/34 ,  G01R33/36 ,  G01R33/20

CPC分类号： B82Y15/00 ,  A61B5/055 ,  A61B5/4381 ,  A61M25/1002 ,  A61M25/1011 ,  G01R33/285 ,  G01R33/341 ,  G01R33/3628 ,  A61M2025/1013 ,  A61M2025/107 ,  A61M2025/1084 ,  G01R33/34084 ,  G01R33/3621 ,  G01R33/3657

摘要： An insertable pickup probe and interface network for magnetic resonance imaging and spectroscopy. The pickup probe in the preferred embodiment is for use in imaging the male prostate and comprises an elongated shaft supporting a patient interface balloon at its distal end which contains a RF receiving coil. The interface balloon comprises an inflatable inner balloon enclosed by a flexible outer balloon. The receiving coil is positioned between the inner and outer balloons and placed intimately adjacent the region of interest by inflating the inner balloon to expand outwardly against the outer balloon. In addition, a non-stretchable planar material is provided on the surface on the inner balloon adjacent the receiving coil for ensuring that the receiving coil is placed adjacent the region of interest. The inner balloon is inflated by an inflator cuff connected to the shaft and communicated to the inner balloon by a first lumen in the shaft. The receiving coil is electrically connected to an interconnecting cable which is connected to the proximal end of the shaft and communicated to the receiving coil by a second lumen in the shaft.

摘要翻译： 可插入的探头和用于磁共振成像和光谱学的接口网络。 优选实施例中的拾取探头用于成像男性前列腺，并且包括在其远端支撑患者接口球囊的细长轴，其包含RF接收线圈。 界面气囊包括由柔性外气囊包围的可充气内球囊。 接收线圈定位在内气囊和外气囊之间，通过使内气囊膨胀而相对于外球囊向外膨胀而紧密地邻近感兴趣区域。 此外，在邻近接收线圈的内球囊的表面上设置非伸缩平面材料，以确保接收线圈位于感兴趣区域附近。 内球囊被连接到轴的充气器套筒充气，并且通过轴中的第一内腔与内球囊相通。 接收线圈电连接到互连电缆，该互连电缆连接到轴的近端并通过轴中的第二内腔连接到接收线圈。

公开(公告)号：US06833705B2

公开(公告)日：2004-12-21

申请号：US10082818

申请日：2002-02-25

申请人： George J. Misic

发明人： George J. Misic

IPC分类号： G01V300

CPC分类号： G01R33/3664 ,  G01R33/3415 ,  G01R33/3678

摘要： A coil interface allows a neurovascular coil system to be coupled to a magnetic resonance (MR) system. The neurovascular coil system has an array of coils including a birdcage coil, a spine coil, and at least one neck coil, with the MR system being equipped with a number of receivers. The coil interface includes a plurality of input ports, a plurality of output ports, and an interface circuit. The plurality of input ports are for coupling to the coils of the neurovascular coil system, and the plurality of output ports for coupling to the receivers of the MR system. The interface circuit enables the input ports and output ports to be selectively interconnected, and thereby enables the neurovascular coil system to be selectively operated in (I) a neurovascular mode; (II) a high resolution brain mode; (III) a high speed brain mode; and (IV) a volume neck mode.

摘要翻译： 线圈接口允许神经血管线圈系统耦合到磁共振（MR）系统。 神经血管线圈系统具有包括鸟笼线圈，脊线圈和至少一个颈线圈的线圈阵列，MR系统配备有多个接收器。 线圈接口包括多个输入端口，多个输出端口和接口电路。 多个输入端口用于耦合到神经血管线圈系统的线圈，以及用于耦合到MR系统的接收器的多个输出端口。 接口电路使得输入端口和输出端口能够选择性地互连，从而使得神经血管线圈系统能够以（I）神经血管模式选择性地操作; （二）高分辨率脑模式; （三）高速脑模式; 和（IV）体积颈部模式。

公开(公告)号：US06396273B2

公开(公告)日：2002-05-28

申请号：US09776132

申请日：2001-02-02

申请人： George J. Misic

发明人： George J. Misic

IPC分类号： G01V300

CPC分类号： G01R33/3415

摘要： A magnetic resonance imaging receiver/transmitter coil system for providing images for regions of interest includes a first phased array formed of a plurality of electrically conductive members and defining an array volume and a second phased array formed of a second plurality of electrically conductive members and disposed at least partially within the defined array volume. At least one of the first and second phased arrays is adapted to apply a magnetic field to the defined array volume. At least one of the first and second phased arrays is further adapted to receive said applied magnetic field. The first phased array is extendible to define a further array volume and is provided with a switch for electrically coupling and decoupling an extension to effectively extend the length of the first phased array and thereby define the further array volume. In this manner the length of the first phased array is effectively extended to approximately twice its unextended length.

摘要翻译： 用于为感兴趣区域提供图像的磁共振成像接收器/发射器线圈系统包括由多个导电构件形成并限定阵列体积的第一相控阵列和由第二多个导电构件形成的第二相控阵列， 至少部分地在定义的阵列卷内。 第一和第二相控阵列中的至少一个适于将磁场施加到限定的阵列体积。 所述第一和第二相控阵列中的至少一个进一步适于接收所述施加的磁场。 第一相控阵可扩展以限定另一个阵列体积，并设置有用于电耦合和解耦延伸的开关，以有效地延长第一相控阵列的长度，从而限定另外的阵列体积。 以这种方式，第一相控阵列的长度有效地延伸到其未延伸长度的大约两倍。

公开(公告)号：US6040697A

公开(公告)日：2000-03-21

申请号：US979842

申请日：1997-11-26

申请人： George J. Misic

发明人： George J. Misic

IPC分类号： G01R33/3415 ,  G01V3/00

CPC分类号： G01R33/3415

摘要： A magnetic resonance imaging receiver/transmitter coil system for providing images for regions of interest includes a first phased array formed of a plurality of electrically conductive members and defining an array volume and a second phased array formed of a second plurality of electrically conductive members and disposed at least partially within the defined array volume. At least one of the first and second phased arrays is adapted to apply a magnetic field to the defined array volume. At least one of the first and second phased arrays is further adapted to receive said applied magnetic field. The first phased array is extendible to define a further array volume and is provided with a switch for electrically coupling and decoupling an extension to effectively extend the length of the first phased array and thereby define the further array volume. In this manner the length of the first phased array is effectively extended to approximately twice its unextended length.

公开(公告)号：US5517120A

公开(公告)日：1996-05-14

申请号：US158052

申请日：1993-11-24

申请人： George J. Misic ,  William J. Monski ,  Eric Reid

发明人： George J. Misic ,  William J. Monski ,  Eric Reid

IPC分类号： G01R33/34 ,  G01V3/00 ,  A61B5/055

CPC分类号： G01R33/34046

摘要： A quadrature coil with a unique arrangement of vertical and horizonal mode coils allows for superior magnetic resonance imaging and spectroscopy through higher sensitivity and more uniform imaging over the region from the head to the crest of the aortic arch. The coil has vertical-mode conductors at approximately 30.degree., 150.degree., 210.degree.and 330.degree.with respect to a longitudinal axis, and horizontal-mode conductors at 90.degree.and 270.degree.. The horizontal-mode conductors are connected at the far end of the coil at an electrical midpoint of the horizontal-mode conductors, such that a voltage null will exist there when the coil is operated in vertical mode. The vertical and horizontal mode feedpoints are located at a head end of the coil, which is hinged into halves to permit easy access by and to a patient.

摘要翻译： 具有垂直和水平模式线圈的独特布置的正交线圈允许通过在主动脉弓的头部到顶部的区域的更高的灵敏度和更均匀的成像来获得优异的磁共振成像和光谱。 线圈相对于纵向轴线具有约30°，150°，210°和330°的垂直模式导体，90°和270°的水平模式导体。 水平模式导体在水平模式导体的电中点处连接在线圈的远端处，使得当线圈以垂直模式操作时，电压为零。 垂直和水平模式馈送点位于线圈的头端，其被铰接成两半以允许容易地通过患者和患者进入。

公开(公告)号：US5348010A

公开(公告)日：1994-09-20

申请号：US949918

申请日：1992-09-24

申请人： Mitchell D. Schnall ,  Robert E. Lenkinski ,  Herbert Y. Kressel ,  Howard M. Pollack ,  Theodore C. Claiborne ,  George J. Misic ,  Thomas R. Welch ,  Edward J. Rhinehart

发明人： Mitchell D. Schnall ,  Robert E. Lenkinski ,  Herbert Y. Kressel ,  Howard M. Pollack ,  Theodore C. Claiborne ,  George J. Misic ,  Thomas R. Welch ,  Edward J. Rhinehart

IPC分类号： A61B5/055 ,  A61F2/958 ,  A61M25/095 ,  G01R33/34 ,  G01R33/36 ,  A61B5/55

CPC分类号： G01R33/341 ,  A61B5/055 ,  A61B5/4381 ,  A61M25/1011 ,  G01R33/34084 ,  A61M2025/1013 ,  A61M25/1002 ,  G01R33/34007 ,  G01R33/3657

摘要： An insertable pickup probe and interface network for magnetic resonance imaging and spectroscopy. The pickup probe in the preferred embodiment is for use in imaging the male prostate and comprises an elongated shaft supporting a patient interface balloon at its distal end which contains a RF receiving coil. The interface balloon comprises an inflatabe inner balloon enclosed by a flexible outer balloon. The receiving coil is positioned between the inner and outer balloons and placed intimately adjacent the region of interest by inflating the inner balloon to expand outwardly against the outer balloon. In addition, a non-stretchable planar material is provided on the surface on the inner balloon adjacent the receiving coil for ensuring that the receiving coil is placed adjacent the region of interest. The inner balloon is inflated by an inflator cuff connected to the shaft and communicated to the inner balloon by a first lumen in the shaft. The receiving coil is electrically connected to an interconnecting cable which is connected to the proximal end of the shaft and communicated to the receiving coil by a second lumen in the shaft. An interface network is also provided which receives the interconnecting cable of the pickup probe and includes impedance matching means, tuning means, and decoupling means for interfacing the probe with a magnetic resonance imaging scanner. In addition, the interface includes an electronic circuit for automatically adjusting the control voltage of a varactor diode in a Pi network which comprises the tuning means.

摘要翻译： 可插入的探头和用于磁共振成像和光谱学的接口网络。 优选实施例中的拾取探头用于成像男性前列腺，并且包括在其远端支撑患者接口球囊的细长轴，其包含RF接收线圈。 界面气囊包括由柔性外气囊包围的发泡内气囊。 接收线圈定位在内气囊和外气囊之间，通过使内气囊膨胀而相对于外球囊向外膨胀而紧密地邻近感兴趣区域。 此外，在邻近接收线圈的内球囊的表面上设置非伸缩平面材料，以确保接收线圈位于感兴趣区域附近。 内球囊被连接到轴的充气器套筒充气，并且通过轴中的第一内腔与内球囊相通。 接收线圈电连接到互连电缆，该互连电缆连接到轴的近端并通过轴中的第二内腔连接到接收线圈。 还提供接口网络，其接收拾取探针的互连电缆，并且包括阻抗匹配装置，调谐装置和用于将探针与磁共振成像扫描器对接的去耦装置。 此外，该接口包括用于在包括调谐装置的Pi网络中自动调节变容二极管的控制电压的电子电路。