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公开(公告)号：US20100087336A1
公开(公告)日：2010-04-08
申请号：US12558523
申请日：2009-09-12
申请人： George Jackson , Roger McNichols , Ulrich Strych , George E. Fox , Victor G. Stepanov , Yamei Liu
发明人： George Jackson , Roger McNichols , Ulrich Strych , George E. Fox , Victor G. Stepanov , Yamei Liu
CPC分类号： G01N33/5308
摘要： The present invention relates to methods of generating amounts of selective nucleic acids. The present invention further relates to selective nucleic acids incorporated within non-coding nucleic acids, capable of binding to or altering a target molecule. Selective nucleic acids may generally refer to, but are not limited to, deoxyribonucleic acids (DNAs), ribonucleic acids (RNAs), artificially modified nucleic acids, combinations or modifications thereof. Selective nucleic acids may also generally refer to, but are not limited to, nucleic acid aptamers, aptazymes, ribozymes, deoxyribozymes, nucleic acid probes, small interfering RNAs (siRNAs), micro RNAs (miRNAs), short hairpin RNAs (shRNAs), antisense nucleic acids, diagnostic probes or probe libraries, aptamer inhibitors, precursors of any of the above and/or combinations or modifications thereof. In one aspect, a method for generating amounts of selective nucleic acids includes incorporating a selective nucleic acid sequence into a carrier nucleic acid. In general, the carrier nucleic acid may be transcribed by a cell into a product nucleic acid which may carry an incorporated selective nucleic acid sequence.
摘要翻译： 本发明涉及产生选择性核酸量的方法。 本发明还涉及掺入非编码核酸中的能够结合或改变靶分子的选择性核酸。 选择性核酸通常可以指但不限于脱氧核糖核酸（DNA），核糖核酸（RNA），人造修饰的核酸，其组合或修饰。 选择性核酸还可以通常指但不限于核酸适体，适体，核酶，脱氧核酶，核酸探针，小干扰RNA（siRNA），微RNA（miRNA），短发夹RNA（shRNA），反义 核酸，诊断探针或探针文库，适体抑制剂，上述任一种的前体和/或其组合或修饰。 一方面，产生选择性核酸量的方法包括将选择性核酸序列掺入载体核酸中。 通常，载体核酸可以被细胞转录成可以携带掺入的选择性核酸序列的产物核酸。
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公开(公告)号：US08916376B2
公开(公告)日：2014-12-23
申请号：US12121658
申请日：2008-05-15
CPC分类号： C12N15/1048
摘要： The present invention is generally directed to novel functionalized biomolecules and methods for generating such biomolecules. Biomolecules may generally include nucleic acids, peptides, multicomponent molecular complexes and/or any other molecular products that may be produced by living organisms. The present invention is further directed to cells and/or organisms manipulated to produce such functionalized biomolecules. The cells contemplated by the present invention include both prokaryotic as well as eukaryotic cells. The functionalized biomolecules are produced via materials introduced into the cell using standard molecular biology techniques or are incorporated within the genomic nucleic acid of a cell by standard recombination techniques. Further contemplated is the use of such cells for sequestration of target molecules within the cells.
摘要翻译： 本发明一般涉及新的功能化生物分子和产生这种生物分子的方法。 生物分子通常可以包括可由活生物体产生的核酸，肽，多组分分子复合物和/或任何其它分子产物。 本发明进一步涉及被操作以产生这种官能化生物分子的细胞和/或生物。 本发明考虑的细胞包括原核细胞以及真核细胞。 功能化生物分子通过使用标准分子生物学技术引入细胞的材料产生，或通过标准重组技术并入细胞的基因组核酸中。 进一步考虑的是使用这种细胞来封存细胞内的靶分子。
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公开(公告)号：US20120165225A1
公开(公告)日：2012-06-28
申请号：US12121658
申请日：2008-05-15
CPC分类号： C12N15/1048
摘要： The present invention is generally directed to novel functionalized biomolecules and methods for generating such biomolecules. Biomolecules may generally include nucleic acids, peptides, multicomponent molecular complexes and/or any other molecular products that may be produced by living organisms. The present invention is further directed to cells and/or organisms manipulated to produce such functionalized biomolecules. The cells contemplated by the present invention include both prokaryotic as well as eukaryotic cells. The functionalized biomolecules are produced via materials introduced into the cell using standard molecular biology techniques or are incorporated within the genomic nucleic acid of a cell by standard recombination techniques. Further contemplated is the use of such cells for sequestration of target molecules within the cells.
摘要翻译： 本发明一般涉及新的功能化生物分子和产生这种生物分子的方法。 生物分子通常可以包括可由活生物体产生的核酸，肽，多组分分子复合物和/或任何其它分子产物。 本发明进一步涉及被操作以产生这种官能化生物分子的细胞和/或生物。 本发明考虑的细胞包括原核细胞以及真核细胞。 功能化生物分子通过使用标准分子生物学技术引入细胞的材料产生，或通过标准重组技术并入细胞的基因组核酸中。 进一步考虑的是使用这种细胞来封存细胞内的靶分子。
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公开(公告)号：US06749433B2
公开(公告)日：2004-06-15
申请号：US10214283
申请日：2002-08-06
申请人： Kenzou Kassai , Tsuguhiro Fukuda , Yamei Liu
发明人： Kenzou Kassai , Tsuguhiro Fukuda , Yamei Liu
IPC分类号： G09B2332
CPC分类号： G09B23/30
摘要： A neonate dummy make it possible to sense or measure a movement of the head of a neonate, the values of impacts applied to the thoracic part and the abdominal part (including the lumbar part) of the neonate, and the value or magnitude of the effect on the cervical vertebrae, as well as to clarify the mechanism of cervical disorder resulting from an impact in a car crash or the like. This neonate dummy includes a head part, a body part (including a lumbar part), arm parts and leg parts. A bar-shaped backbone member corresponding to the backbone of a neonate is provided in the body part (including a lumbar part), and a neck part is formed on an upper region of the backbone member. A triaxial acceleration sensor is provided on the centroidal position of the head part. Further triaxial acceleration sensors are provided on positions of the backbone member corresponding to the upper and lower ends of the cervical vertebrae of the neonate respectively, and additional triaxial acceleration sensors are provided on the centroidal positions of a thoracic part and a lumbar part respectively.
摘要翻译： 新生儿假人可以感觉或测量新生儿头部的运动，应用于新生儿的胸部和腹部（包括腰部）的影响的值，以及影响的价值或幅度 在颈椎上，以及阐明由于车祸等影响引起的宫颈疾病的机制。 这个新生儿假人包括头部，身体部分（包括腰部），手臂部分和腿部。 在主体部（包括腰部）中设置与新生儿的骨架对应的棒状骨架构件，在骨架构件的上部区域形成有颈部。 在头部的重心位置设有三轴加速度传感器。 其他三轴加速度传感器分别设置在与新生儿颈椎的上端和下端相对应的骨干构件的位置上，另外的三轴加速度传感器分别设置在胸部和腰部的中心位置。
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