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25 条记录 (耗时 0.032 秒)

    Tetrazole derivatives of 1,3-dioxane and thromboxane A.sub.2 antigonizing use thereof
    2.
    发明授权
    Tetrazole derivatives of 1,3-dioxane and thromboxane A.sub.2 antigonizing use thereof 失效
    1,3-二恶烷的四氮唑衍生物和血栓素A2的防止其使用

    公开(公告)号：US4831046A

    公开(公告)日：1989-05-16

    申请号：US861334

    申请日：1986-05-09

    申请人： George R. Brown ,  Michael J. Smithers

    发明人： George R. Brown ,  Michael J. Smithers

    IPC分类号： C07D401/06 ,  A61K31/41 ,  A61P7/02 ,  A61P9/08 ,  A61P11/08 ,  A61P43/00 ,  C07D319/00 ,  C07D319/06 ,  C07D405/06 ,  C12N9/99

    CPC分类号： C07D405/06 ,  C07D319/06

    摘要： The invention describes various novel tetrazole derivatives of the formula I in which R.sup.1 and R.sup.2 are independently hydrogen, trifluoromethyl or (1-6C)alkyl (but R.sup.1 and R.sup.2 is not greater than 6 carbon atoms), or R.sup.1 is optionally substituted phenyl and R.sup.2 is hydrogen, Y is vinylene, n is 1 or 2 and m is 1, 2 or 3, or a pharmaceutically acceptable salt thereof, for use in conjunction with their pharmaceutical compositions in the treatment of various pulmonary and/or vascular disorders. Also described are various processes and intermediates for the manufacture of the novel compounds.

    摘要翻译： 本发明描述了式I的各种新型四唑衍生物，其中R 1和R 2独立地为氢，三氟甲基或（1-6C）烷基（但R 1和R 2不大于6个碳原子），或R 1为任选取代的苯基和R 2 是氢，Y是亚乙烯基，n是1或2，m是1,2或3，或其药学上可接受的盐，用于与其药物组合物联合用于治疗各种肺和/或血管疾病。 还描述了用于制备新化合物的各种方法和中间体。

    Alkene derivatives
    4.
    发明授权
    Alkene derivatives 失效
    烯烃衍生物

    公开(公告)号：US5047412A

    公开(公告)日：1991-09-10

    申请号：US304718

    申请日：1989-02-01

    申请人： George R. Brown ,  Michael J. Smithers

    发明人： George R. Brown ,  Michael J. Smithers

    IPC分类号： C07D319/06

    CPC分类号： C07D319/06

    摘要： The invention describes novel (2-styryl-, 2-naphthyl- and 2-phenethyl-4-o-hydroxyphenyl-1,3-dioxan-5-yl)alkenoic acids and related tetrazoles and sulphonamides, of the formula I wherein Q completes a benzene or pyridine ring, Y is vinylene, Z is carboxy, 1(H)-tetrazol-5-yl or a group of the formula --CO.NHSO.sub.2 R.sup.6, and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, A.sup.1, A.sup.2, n and m have the meanings defined in the specification, and pharmaceutically acceptable salts thereof, for use in conjunction with their pharmaceutical compositions in treating certain pulmonary and/or vascular disorders. The invention also describes various processes and intermediates for the manufacture of the novel compounds.

    2,4-diphenyl-1,3-dioxanes
    7.
    发明授权
    2,4-diphenyl-1,3-dioxanes 失效
    2,4-二苯基-1,3-二恶烷

    公开(公告)号：US4775685A

    公开(公告)日：1988-10-04

    申请号：US861329

    申请日：1986-05-09

    申请人： Andrew G. Brewster ,  George R. Brown ,  Michael J. Smithers

    发明人： Andrew G. Brewster ,  George R. Brown ,  Michael J. Smithers

    IPC分类号： A61K31/335 ,  A61K31/357 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  C07D319/06

    CPC分类号： C07D319/06

    摘要： The invention provides a novel group of 4(Z)-([2,4,5-cis]-2,4-diphenyl-1,3-dioxan-5-yl)hexenoic acids of formula I, wherein X is F, Cl, Br, CF.sub.3, CN, CH.sub.3 O or NO.sub.2 and one of Y and Z is hydrogen or fluoro and the other is hydrogen, and their pharmaceutically acceptable salts; together with their pharmaceutical compositions for use in treating a variety of disease conditions. Also provided are methods for the manufacture of novel compounds. Representative compounds are those in which X is 2-cyano or 2-chloro and Y and Z are both hydrogen.

    摘要翻译： 本发明提供了式I的4（Z） - （[2,4,5-顺式] -2,4-二苯基-1,3-二恶烷-5-基）己烯酸的新型基团，其中X为F， Cl，Br，CF 3，CN，CH 3 O或NO 2，Y和Z中的一个为氢或氟，另一个为氢，及其药学上可接受的盐; 以及用于治疗各种疾病状况的药物组合物。 还提供了制备新化合物的方法。 代表性的化合物是其中X是2-氰基或2-氯并且Y和Z都是氢的化合物。

    4-pyridyl-1,3-dioxane derivatives
    8.
    发明授权
    4-pyridyl-1,3-dioxane derivatives 失效
    4-吡啶基-1,3-二恶烷衍生物

    公开(公告)号：US5401849A

    公开(公告)日：1995-03-28

    申请号：US78658

    申请日：1993-06-21

    申请人： Andrew G. Brewster ,  George R. Brown ,  Alan W. Faull ,  Reginald Jessup ,  Michael J. Smithers

    发明人： Andrew G. Brewster ,  George R. Brown ,  Alan W. Faull ,  Reginald Jessup ,  Michael J. Smithers

    IPC分类号： C07D405/04 ,  C07D405/14

    CPC分类号： C07D405/04 ,  C07D405/14

    摘要： The invention concerns pharmaceutically useful 1,3-dioxane alkenoic acid derivatives of formula VII and formula XI containing a pyridyl moiety at position 4 of the dioxane ring and in which the groups at positions 2, 4 and 5 have cis-relative stereochemistry, wherein X is hydrogen, alkoxy or hydroxy, Y is vinylene, n is 1 or 2, A.sup.1 is alkylene, R.sup.1 is a variety of substituents defined hereinafter, Ra and Rb are independently methyl or ethyl, R.sup.2 is hydroxy, a physiologically acceptable alcohol residue or alkanesulphonamido, and the pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明涉及式VII和式XI的药学上有用的1,3-二恶烷烯酸衍生物，其在二恶烷环的4位含有吡啶基部分，其中2,4和5位的基团具有顺式相对立体化学，其中X 是氢，烷氧基或羟基，Y是亚乙烯基，n是1或2，A1是亚烷基，R1是下文定义的各种取代基，R a和R b独立地是甲基或乙基，R 2是羟基，生理上可接受的醇残基或烷基磺酰胺 ，及其药学上可接受的盐。