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公开(公告)号：US07030104B2
公开(公告)日：2006-04-18
申请号：US10129040
申请日：2001-09-14
CPC分类号： A61K9/0014 , A61K9/06 , A61K9/7015 , A61K31/57 , A61K31/565 , A61K2300/00
摘要： The present invention relates to the field of therapeutic chemistry and more especially to the realization of new galenic forms intended to be applied on the skin.More particularly it relates to a topical hormonal composition with a systemic effect for the hormonal treatment of the perimenopause and of the menopause as well as for the treatment of the ovarian hormonal deficiencies in women with amenorrhea, characterized in that it comprises, as active ingredients, a progestogen derived from 19-nor progesterone and estradiol or one of its derivatives, a vehicle which allows the systemic passage of said active ingredients, chosen from the group constituted by a solubilizing agent, an absorption promoting agent, a film-forming agent, a gelling agent and their mixtures, in combination or in a mixture with suitable excipients for the realization of a gelled and/or film-forming pharmaceutical form.
摘要翻译： 本发明涉及治疗化学领域，更具体地涉及旨在应用于皮肤的新的盖仑型形式的实现。 更具体地说，本发明涉及一种局部激素组合物，具有用于激素治疗围绝经期和绝经期以及用于治疗闭经妇女的卵巢激素缺乏的全身效应，其特征在于，其包含作为活性成分的， 衍生自19-没有孕酮和雌二醇或其衍生物之一的孕激素，其允许所述活性成分的全身通过，所述载体选自由增溶剂，吸收促进剂，成膜剂， 胶凝剂及其混合物，组合或与合适的赋形剂的混合物，以实现胶凝和/或成膜药物形式。
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公开(公告)号：US09795644B2
公开(公告)日：2017-10-24
申请号：US13376238
申请日：2010-06-07
摘要： The invention relates to grass pollen extracts containing reduced amount of flavonoid glycosides in order to minimize the risks of genotoxicity of the grass pollen extracts. The invention also relates to a method of preparing grass pollen extracts containing reduced amount of flavonoid glycosides by ultrafiltration. Flavonoid glycosides are naturally present in grass pollen extracts and they have been identified as being responsible for the formation of flavonoid aglycones, which are genotoxic in vitro, under the influence of enzymes contained in the grass pollen extracts.
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3.发明申请REDUCTION OF IN VITRO GENOTOXICITY OF POLLEN EXTRACTS BY REMOVAL OF FLAVONOIDS 有权通过去除花生四烯酸可以减少花生提取物的生殖细胞毒性公开(公告)号：US20120148626A1
公开(公告)日：2012-06-14
申请号：US13376238
申请日：2010-06-07
IPC分类号： A61K39/36 , A61P37/02 , A61K36/899
摘要： The invention relates to grass pollen extracts containing reduced amount of flavonoid glycosides in order to minimize the risks of genotoxicity of the grass pollen extracts. The invention also relates to a method of preparing grass pollen extracts containing reduced amount of flavonoid glycosides by ultrafiltration. Flavonoid glycosides are naturally present in grass pollen extracts and they have been identified as being responsible for the formation of flavonoid aglycones, which are genotoxic in vitro, under the influence of enzymes contained in the grass pollen extracts.
摘要翻译： 本发明涉及含有减少量的黄酮苷的草花粉提取物，以使草花粉提取物的遗传毒性风险最小化。 本发明还涉及通过超滤制备含有减少量的类黄酮苷的草花粉提取物的方法。 黄酮苷是天然存在于草花粉提取物中，它们被鉴定为负责在花粉提取物中含有酶的影响下在体外基因毒性的类黄酮糖苷配基的形成。
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