公开(公告)号：US20200306234A1

公开(公告)日：2020-10-01

申请号：US16089794

申请日：2017-03-31

申请人： Georgetown University ,  The Board of Regents of the University of Oklahoma

发明人： Milton L. Brown ,  Yali Kong ,  Courtney Houchen ,  Sripathi M. Sureban ,  Parthasarathy Chandrakesan

IPC分类号： A61K31/454 ,  A61K31/4184 ,  A61P39/00

摘要： Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein Z is —O—or —N(H)—.

公开(公告)号：US11311526B2

公开(公告)日：2022-04-26

申请号：US16089794

申请日：2017-03-31

申请人： Georgetown University ,  The Board of Regents of the University of Oklahoma

发明人： Milton L. Brown ,  Yali Kong ,  Courtney Houchen ,  Sripathi M. Sureban ,  Parthasarathy Chandrakesan

IPC分类号： A61K31/454 ,  A61P39/00 ,  A61K31/4184

摘要： Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.

公开(公告)号：US20230310407A1

公开(公告)日：2023-10-05

申请号：US18207447

申请日：2023-06-08

申请人： Georgetown University ,  The Board of Regents of the University of Oklahoma

发明人： Milton L. Brown ,  Yali Kong ,  Courtney Houchen ,  Sripathi M. Sureban ,  Parthasarathy Chandrakesan

IPC分类号： A61K31/454 ,  A61P39/00 ,  A61K31/4184

CPC分类号： A61K31/454 ,  A61P39/00 ,  A61K31/4184

摘要： Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I




or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.

公开(公告)号：US20230033749A1

公开(公告)日：2023-02-02

申请号：US17728485

申请日：2022-04-25

申请人： Georgetown University ,  The Board of Regents of the University of Oklahoma

发明人： Milton L. Brown ,  Yali Kong ,  Courtney Houchen ,  Sripathi M. Sureban ,  Parthasarathy Chandrakesan

IPC分类号： A61K31/454 ,  A61P39/00 ,  A61K31/4184

摘要： Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.

公开(公告)号：US11672789B2

公开(公告)日：2023-06-13

申请号：US17728485

申请日：2022-04-25

申请人： Georgetown University ,  The Board of Regents of the University of Oklahoma

发明人： Milton L. Brown ,  Yali Kong ,  Courtney Houchen ,  Sripathi M. Sureban ,  Parthasarathy Chandrakesan

IPC分类号： A61K31/454 ,  A61P39/00 ,  A61K31/4184

CPC分类号： A61K31/454 ,  A61K31/4184 ,  A61P39/00

摘要： Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I




or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.

公开(公告)号：US11655307B2

公开(公告)日：2023-05-23

申请号：US16617074

申请日：2018-05-30

申请人： The Board of Regents of the University of Oklahoma

发明人： Courtney W. Houchen ,  Nathaniel Weygant ,  Dongfeng Qu ,  Randal May ,  Parthasarathy Chandrakesan ,  William L. Berry

IPC分类号： A61P35/00 ,  A61K47/68 ,  A61K39/00 ,  C07K16/40

CPC分类号： C07K16/40 ,  A61K47/6871 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/92

摘要： Antibodies and antigen-binding fragments thereof that specifically bind to human DCLK1 protein, hybridomas or other cell lines which express such antibodies and antigen-binding fragments thereof, nucleic acids, vectors, and host cells comprising nucleic acids which encode such antibodies and antigen-binding fragments thereof, and methods of use thereof are disclosed. In at least certain non-limiting embodiments, the antibodies or antigen-binding fragments thereof specifically bind to an epitope within isoform 2 or 4 of DCLK1 protein.