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公开(公告)号：US20100160371A1
公开(公告)日：2010-06-24
申请号：US12619913
申请日：2009-11-17
申请人： Gerald RANGES , William Scott , Michael Bombara , Deborah Rauner , Aniko Redman , Roger Smith , Holger Paulsen , David Gunn , Jinshan Chen , Joel Renick
发明人： Gerald RANGES , William Scott , Michael Bombara , Deborah Rauner , Aniko Redman , Roger Smith , Holger Paulsen , David Gunn , Jinshan Chen , Joel Renick
IPC分类号： A61K31/381 , A61K31/341 , A61K31/40 , A61K31/433 , A61K31/47 , A61K31/404 , A61P29/00 , A61P37/00 , A61P19/10 , A61P11/06
CPC分类号： A61K31/4709 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/433 , Y02A50/401 , Y02A50/411 , Y02A50/414
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical compositions for use in such therapy.
摘要翻译： 本发明涉及一组芳基脲在治疗癌症以外的细胞因子介导的疾病和除了癌症以外的蛋白水解酶介导的疾病以及用于这种治疗的药物组合物中的用途。
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公开(公告)号：US06344476B1
公开(公告)日：2002-02-05
申请号：US09083396
申请日：1998-05-22
申请人： Gerald Ranges , William Scott , Michael Bombara , Deborah Rauner , Aniko Redman , Roger Smith , Holger Paulsen , David Gunn , Jinshan Chen , Joel Renick
发明人： Gerald Ranges , William Scott , Michael Bombara , Deborah Rauner , Aniko Redman , Roger Smith , Holger Paulsen , David Gunn , Jinshan Chen , Joel Renick
IPC分类号： A61K3138
CPC分类号： A61K31/4709 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/433 , Y02A50/411 , Y02A50/414
摘要： This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical compositions for use in such therapy.
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3.发明申请公开(公告)号：US20060019990A1
公开(公告)日：2006-01-26
申请号：US11158048
申请日：2005-06-22
申请人： Jacques Dumas , Bernd Riedl , Uday Khire , Robert Sibley , Holia Hatoum-Mokdad , Mary-Katherine Monahan , David Gunn , Timotthy Lowinger , William Scott , Roger Smith , Jill Wood
发明人： Jacques Dumas , Bernd Riedl , Uday Khire , Robert Sibley , Holia Hatoum-Mokdad , Mary-Katherine Monahan , David Gunn , Timotthy Lowinger , William Scott , Roger Smith , Jill Wood
IPC分类号： A61K31/4709 , A61K31/444 , C07D401/02
CPC分类号： C07D213/40
摘要： The invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in such therapy.
摘要翻译： 本发明涉及一组喹啉基，异喹啉基和吡啶基脲，它们在治疗raf介导的疾病中的用途，以及含有用于这种治疗的这些尿素的药物组合物。
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4.发明申请1, 8-Naphthyridine derivatives and their use to treat diabetes and related disorders 审中-公开1,8-萘啶衍生物及其用于治疗糖尿病和相关疾病的用途公开(公告)号：US20060189609A1
公开(公告)日：2006-08-24
申请号：US11409536
申请日：2006-04-21
申请人： Yamin Wang , William Bullock , David Gunn , Qingjie Liu , Sidney Liang , Donglei Liu , Steven Magnuson , Tindy Li , Eric Mull , Jill Wood , Ning Qi
发明人： Yamin Wang , William Bullock , David Gunn , Qingjie Liu , Sidney Liang , Donglei Liu , Steven Magnuson , Tindy Li , Eric Mull , Jill Wood , Ning Qi
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号： A61K45/06 , A61K31/44 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D471/04 , A61K2300/00
摘要： The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,8-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.
摘要翻译： 本发明一般涉及下式的萘啶衍生物，其中U，X，Y和Z中的一个为氮，其余为C-R，其中R为氢或取代基。 更具体地，本发明涉及1,8-萘啶衍生物和含有这些衍生物的药物组合物。 本发明的方法包括施用本发明的萘啶衍生物用于治疗糖尿病和相关疾病。
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公开(公告)号：US20080214540A1
公开(公告)日：2008-09-04
申请号：US11999524
申请日：2007-12-04
IPC分类号： A61K31/428 , C07D419/06 , A61K31/5377 , A61P3/10 , C07D417/14
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
摘要翻译： 公开了用于治疗由糖尿病引起的慢性并发症的取代吲哚烷酸。 还公开了含有化合物的化合物和使用该化合物的治疗方法的药物组合物，以及它们的合成方法。
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公开(公告)号：US07105514B2
公开(公告)日：2006-09-12
申请号：US10832724
申请日：2004-04-27
IPC分类号： A61K31/535 , C07D417/06
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
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公开(公告)号：US06426344B2
公开(公告)日：2002-07-30
申请号：US09818808
申请日：2001-03-27
IPC分类号： A61K31535
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
摘要翻译： 公开了用于治疗由糖尿病引起的慢性并发症的取代的吲哚烷酸。 还公开了含有化合物的化合物和使用该化合物的治疗方法的药物组合物，以及它们的合成方法。
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公开(公告)号：US20100324039A1
公开(公告)日：2010-12-23
申请号：US12871293
申请日：2010-08-30
IPC分类号： A61K31/5377 , C07D417/06 , A61K31/428 , C07D209/10 , A61K31/405 , C07D413/14 , A61P3/10 , A61P13/12 , A61P25/00 , A61P27/02
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
摘要翻译： 公开了用于治疗由糖尿病引起的慢性并发症的取代吲哚烷酸。 还公开了含有化合物的化合物和使用该化合物的治疗方法的药物组合物，以及它们的合成方法。
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公开(公告)号：US07304079B2
公开(公告)日：2007-12-04
申请号：US11531151
申请日：2006-09-12
申请人： Michael Jones , David Gunn , John Jones , Michael Van Zandt
发明人： Michael Jones , David Gunn , John Jones , Michael Van Zandt
IPC分类号： A61K31/4439 , A61K31/405 , C07D403/02 , C07D209/18
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
摘要翻译： 公开了用于治疗由糖尿病引起的慢性并发症的取代的吲哚烷酸。 还公开了含有化合物的化合物和使用该化合物的治疗方法的药物组合物，以及它们的合成方法。
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公开(公告)号：US20070093530A1
公开(公告)日：2007-04-26
申请号：US11531151
申请日：2006-09-12
申请人： Michael Jones , David Gunn , John Jones , Michael Van Zandt
发明人： Michael Jones , David Gunn , John Jones , Michael Van Zandt
IPC分类号： A61K31/4439 , A61K31/405 , C07D403/02 , C07D209/18
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
摘要翻译： 公开了用于治疗由糖尿病引起的慢性并发症的取代的吲哚烷酸。 还公开了含有化合物的化合物和使用该化合物的治疗方法的药物组合物，以及它们的合成方法。
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