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公开(公告)号：US07659269B2
公开(公告)日：2010-02-09
申请号：US11999524
申请日：2007-12-04
申请人： Michael Jones , David Gunn , John Jones , Michael Van Zandt
发明人： Michael Jones , David Gunn , John Jones , Michael Van Zandt
IPC分类号： A61K31/535 , A61K31/405 , C07D417/00
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
摘要翻译： 公开了用于治疗由糖尿病引起的慢性并发症的取代的吲哚烷酸。 还公开了含有化合物的化合物和使用该化合物的治疗方法的药物组合物，以及它们的合成方法。
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公开(公告)号：US07304079B2
公开(公告)日：2007-12-04
申请号：US11531151
申请日：2006-09-12
申请人： Michael Jones , David Gunn , John Jones , Michael Van Zandt
发明人： Michael Jones , David Gunn , John Jones , Michael Van Zandt
IPC分类号： A61K31/4439 , A61K31/405 , C07D403/02 , C07D209/18
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
摘要翻译： 公开了用于治疗由糖尿病引起的慢性并发症的取代的吲哚烷酸。 还公开了含有化合物的化合物和使用该化合物的治疗方法的药物组合物，以及它们的合成方法。
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公开(公告)号：US20070093530A1
公开(公告)日：2007-04-26
申请号：US11531151
申请日：2006-09-12
申请人： Michael Jones , David Gunn , John Jones , Michael Van Zandt
发明人： Michael Jones , David Gunn , John Jones , Michael Van Zandt
IPC分类号： A61K31/4439 , A61K31/405 , C07D403/02 , C07D209/18
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
摘要翻译： 公开了用于治疗由糖尿病引起的慢性并发症的取代的吲哚烷酸。 还公开了含有化合物的化合物和使用该化合物的治疗方法的药物组合物，以及它们的合成方法。
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公开(公告)号：US20100324039A1
公开(公告)日：2010-12-23
申请号：US12871293
申请日：2010-08-30
IPC分类号： A61K31/5377 , C07D417/06 , A61K31/428 , C07D209/10 , A61K31/405 , C07D413/14 , A61P3/10 , A61P13/12 , A61P25/00 , A61P27/02
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
摘要翻译： 公开了用于治疗由糖尿病引起的慢性并发症的取代吲哚烷酸。 还公开了含有化合物的化合物和使用该化合物的治疗方法的药物组合物，以及它们的合成方法。
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公开(公告)号：US20060122222A1
公开(公告)日：2006-06-08
申请号：US11282390
申请日：2005-11-18
申请人： Darren Whitehouse , Shaojing Hu , Kerry Combs , Michael Van Zandt
发明人： Darren Whitehouse , Shaojing Hu , Kerry Combs , Michael Van Zandt
IPC分类号： A61K31/47 , A61K31/405 , A61K31/381 , C07D409/02 , C07D403/02 , C07D401/02
CPC分类号： C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/10 , C07D405/12 , C07D409/10 , C07D417/10 , C07D417/12
摘要： The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译： 本发明涉及式（I）的化合物和药学上可接受的盐：其可用于治疗与胰岛素抵抗，瘦素抵抗或高血糖相关的代谢紊乱。 本发明的化合物包括可用于治疗糖尿病和其它PTP介导的疾病如癌症，神经变性疾病等的蛋白质酪氨酸磷酸酶抑制剂，特别是蛋白质酪氨酸磷酸酶-1B（PTP-1B）。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
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公开(公告)号：US09233985B2
公开(公告)日：2016-01-12
申请号：US13276806
申请日：2011-10-19
摘要： Compounds according to Formula I are potent inhibitors of Arginase I and II activity: where R1, R2, R3, R4, D, W, X, Y, and Z are defined in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use in treating or preventing a disease or a condition associated with arginase activity.
摘要翻译： 根据式I的化合物是精氨酸酶I和II活性的有效抑制剂：其中R1，R2，R3，R4，D，W，X，Y和Z在本说明书中定义。 本发明还提供了化合物的药物组合物及其用于治疗或预防与精氨酸酶活性相关的疾病或病症的方法。
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公开(公告)号：US20150191492A1
公开(公告)日：2015-07-09
申请号：US14614115
申请日：2015-02-04
IPC分类号： C07F5/02
摘要： Compounds according to Formula I are potent inhibitors of Arginase I and II activity: where R1, R2, R3, R4, D, W, X, Y, and Z are defined in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use in treating or preventing a disease or a condition associated with arginase activity.
摘要翻译： 根据式I的化合物是精氨酸酶I和II活性的有效抑制剂：其中R1，R2，R3，R4，D，W，X，Y和Z在本说明书中定义。 本发明还提供了化合物的药物组合物及其用于治疗或预防与精氨酸酶活性相关的疾病或病症的方法。
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公开(公告)号：US20060100251A1
公开(公告)日：2006-05-11
申请号：US11262423
申请日：2005-10-28
IPC分类号： A61K31/44 , A61K31/195 , C07D213/55 , C07C311/42
CPC分类号： C07C311/21 , C07C69/65 , C07C311/29 , C07D213/55
摘要： The present invention relates to compounds and pharmaceutically acceptable salts of formula I: which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.
摘要翻译： 本发明涉及式I化合物和药学上可接受的盐：其可用于治疗与胰岛素抵抗或高血糖相关的代谢紊乱。 这些化合物包括可用于治疗糖尿病和其它PTP-1B介导的疾病如癌症，神经变性疾病等的蛋白质酪氨酸磷酸酶（PTP-1B）的抑制剂。 本发明的化合物也可用于治疗上述病症的药物组合物和方法。
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公开(公告)号：US20060094747A1
公开(公告)日：2006-05-04
申请号：US11261019
申请日：2005-10-28
申请人： Michael Van Zandt , Darren Whitehouse , Kerry Combs , Shaojing Hu
发明人： Michael Van Zandt , Darren Whitehouse , Kerry Combs , Shaojing Hu
IPC分类号： A61K31/4745 , A61K31/416 , A61K31/381 , A61K31/423 , A61K31/343 , C07D333/76 , C07D333/72 , C07D471/02
CPC分类号： C07D307/79 , C07C69/65 , C07C69/736 , C07C69/738 , C07C309/65 , C07C2601/16 , C07D307/91
摘要： The present invention relates to compounds and pharmaceutically acceptable salts of formula I: which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.
摘要翻译： 本发明涉及式I化合物和药学上可接受的盐：其可用于治疗与胰岛素抵抗或高血糖相关的代谢紊乱。 这些化合物包括可用于治疗糖尿病和其它PTP-1B介导的疾病如癌症，神经变性疾病等的蛋白质酪氨酸磷酸酶（PTP-1B）的抑制剂。 本发明的化合物也可用于治疗上述病症的药物组合物和方法。
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公开(公告)号：US20120083469A1
公开(公告)日：2012-04-05
申请号：US13090714
申请日：2011-04-20
申请人： Michael Van Zandt , Adam Golebiowski , Min Koo Ji , Darren Whitehouse , Todd Ryder , Paul Beckett
发明人： Michael Van Zandt , Adam Golebiowski , Min Koo Ji , Darren Whitehouse , Todd Ryder , Paul Beckett
IPC分类号： A61K31/69 , A61P9/00 , A61P1/00 , A61P37/00 , A61P31/00 , A61P11/00 , A61P9/12 , A61P9/10 , A61P19/02 , A61P21/04 , A61P25/00 , A61P31/18 , A61P1/04 , A61P17/06 , A61P29/00 , A61P17/02 , A61P15/00 , C12N9/99 , C07F5/02
CPC分类号： C07F5/025
摘要： Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: where R1, R2, R3, R4, R5, R6, R7, R8, R9, D, M, X, and Y are defined as set forth in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use for treating or preventing a disease or a condition associated with arginase activity.
摘要翻译： 根据式I和式II的化合物是精氨酸酶I和II活性的有效抑制剂：其中R1，R2，R3，R4，R5，R6，R7，R8，R9，D，M，X和Y定义如上 在规范中。 本发明还提供了化合物的药物组合物及其用于治疗或预防与精氨酸酶活性相关的疾病或病症的方法。
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