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公开(公告)号：US20090104154A1
公开(公告)日：2009-04-23
申请号：US12292499
申请日：2008-11-20
申请人： Gerald W. Both , Trevor J. Lockett , Peter L. Molloy , Fiona H. Cameron , Pamela J. Russell , Rosetta Martiniello-Wilks , Minoo J. Moghaddam , Ian K. Smith
发明人： Gerald W. Both , Trevor J. Lockett , Peter L. Molloy , Fiona H. Cameron , Pamela J. Russell , Rosetta Martiniello-Wilks , Minoo J. Moghaddam , Ian K. Smith
IPC分类号： A61K35/76
CPC分类号： A61K35/761 , A61K38/45 , A61K45/06 , A61K47/67 , A61K47/6901 , A61K48/00 , A61K48/0041 , B82Y5/00 , C12N7/00 , C12N15/86 , C12N2710/10132 , C12N2710/10143 , C12N2830/008 , C12N2830/15 , A61K2300/00
摘要： The present invention provides a method of treating a solid tumour in a subject, the method comprising the following steps (i) delivering to the solid tumour a composition comprising an engineered ovine atadenovirus; and (ii) administering a prodrug to the subject, wherein the engineered ovine atadenovirus comprises a promoter and a gene encoding an enzyme which converts the prodrug to a cytotoxic metabolite, the gene being under control of the promoter.
摘要翻译： 本发明提供一种治疗受试者的实体肿瘤的方法，所述方法包括以下步骤：（i）向实体瘤递送包含工程改造的腺癌腺病毒的组合物; 并且（ii）向所述受试者施用前药，其中所述工程改造的腺癌腺病毒包含启动子和编码将所述前药转化为细胞毒性代谢物的酶的基因，所述基因处于所述启动子的控制之下。
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公开(公告)号：US20130237586A1
公开(公告)日：2013-09-12
申请号：US13857844
申请日：2013-04-05
IPC分类号： A01N57/16 , A61K31/713
CPC分类号： C12N15/113 , A01K67/0337 , A01K2217/05 , A01N57/16 , A61K31/713 , A61K38/00 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2320/32 , C12N2320/50 , C12Y302/01031
摘要： The invention is to methods of gene silencing in arthropods using dsRNA. The method is include contacting the arthropod with, and/or directly feeding the arthropod, the dsRNA to the arthropods to deliver the dsRNA to arthropod tissues. It is envisaged that the methods of the invention will have use in determining the biological function of genes in arthropods. Methods of pest control of arthropods, and of protecting arthropods against parasites and predators are provided. Transgenic arthropods expressing dsRNA molecules are also provided by the present invention.
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公开(公告)号：US20120309813A1
公开(公告)日：2012-12-06
申请号：US13545604
申请日：2012-07-10
IPC分类号： A01N57/16 , A61P33/00 , A61P31/00 , A61K31/713 , A01P7/04
CPC分类号： C12N15/113 , A01K67/0337 , A01K2217/05 , A01N57/16 , A61K31/713 , A61K38/00 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2320/32 , C12N2320/50 , C12Y302/01031
摘要： The invention is to methods of gene silencing in arthropods using dsRNA. The method is include contacting the arthropod with, and/or directly feeding the arthropod, the dsRNA to the arthropods to deliver the dsRNA to arthropod tissues. It is envisaged that the methods of the invention will have use in determining the biological function of genes in arthropods. Methods of pest control of arthropods, and of protecting arthropods against parasites and predators are provided. Transgenic arthropods expressing dsRNA molecules are also provided by the present invention.
摘要翻译： 本发明是利用dsRNA在节肢动物中进行基因沉默的方法。 该方法包括将节肢动物与节肢动物接触和/或直接喂食节肢动物，将dsRNA与节肢动物接触以将dsRNA递送至节肢动物组织。 预期本发明的方法将用于确定节肢动物中基因的生物学功能。 提供了节肢动物病虫害防治方法以及保护节肢动物免受寄生虫和捕食者的伤害。 表达dsRNA分子的转基因节肢动物也由本发明提供。
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公开(公告)号：US08877727B2
公开(公告)日：2014-11-04
申请号：US13857844
申请日：2013-04-05
CPC分类号： C12N15/113 , A01K67/0337 , A01K2217/05 , A01N57/16 , A61K31/713 , A61K38/00 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2320/32 , C12N2320/50 , C12Y302/01031
摘要： The invention is to methods of gene silencing in arthropods using dsRNA. The method is include contacting the arthropod with, and/or directly feeding the arthropod, the dsRNA to the arthropods to deliver the dsRNA to arthropod tissues. It is envisaged that the methods of the invention will have use in determining the biological function of genes in arthropods. Methods of pest control of arthropods, and of protecting arthropods against parasites and predators are provided. Transgenic arthropods expressing dsRNA molecules are also provided by the present invention.
摘要翻译： 本发明是利用dsRNA在节肢动物中进行基因沉默的方法。 该方法包括将节肢动物与节肢动物接触和/或直接喂食节肢动物，将dsRNA与节肢动物接触以将dsRNA递送至节肢动物组织。 预期本发明的方法将用于确定节肢动物中基因的生物学功能。 提供了节肢动物病虫害防治方法以及保护节肢动物免受寄生虫和捕食者的伤害。 表达dsRNA分子的转基因节肢动物也由本发明提供。
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公开(公告)号：US08263573B2
公开(公告)日：2012-09-11
申请号：US13243413
申请日：2011-09-23
CPC分类号： C12N15/113 , A01K67/0337 , A01K2217/05 , A01N57/16 , A61K31/713 , A61K38/00 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2320/32 , C12N2320/50 , C12Y302/01031
摘要： The invention is to methods of gene silencing in arthropods using dsRNA. The method is include contacting the arthropod with, and/or directly feeding the arthropod, the dsRNA to the arthropods to deliver the dsRNA to arthropod tissues. It is envisaged that the methods of the invention will have use in determining the biological function of genes in arthropods. Methods of pest control of arthropods, and of protecting arthropods against parasites and predators are provided. Transgenic arthropods expressing dsRNA molecules are also provided by the present invention.
摘要翻译： 本发明是利用dsRNA在节肢动物中进行基因沉默的方法。 该方法包括将节肢动物与节肢动物接触和/或直接喂食节肢动物，将dsRNA与节肢动物接触以将dsRNA递送至节肢动物组织。 预期本发明的方法将用于确定节肢动物中基因的生物学功能。 提供了节肢动物病虫害防治方法以及保护节肢动物免受寄生虫和捕食者的伤害。 表达dsRNA分子的转基因节肢动物也由本发明提供。
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公开(公告)号：US20120041053A1
公开(公告)日：2012-02-16
申请号：US13243413
申请日：2011-09-23
IPC分类号： A61K31/713 , A61P43/00
CPC分类号： C12N15/113 , A01K67/0337 , A01K2217/05 , A01N57/16 , A61K31/713 , A61K38/00 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2320/32 , C12N2320/50 , C12Y302/01031
摘要： The invention is to methods of gene silencing in arthropods using dsRNA. The method is include contacting the arthropod with, and/or directly feeding the arthropod, the dsRNA to the arthropods to deliver the dsRNA to arthropod tissues. It is envisaged that the methods of the invention will have use in determining the biological function of genes in arthropods. Methods of pest control of arthropods, and of protecting arthropods against parasites and predators are provided. Transgenic arthropods expressing dsRNA molecules are also provided by the present invention.
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公开(公告)号：US08101343B2
公开(公告)日：2012-01-24
申请号：US10482888
申请日：2002-07-05
CPC分类号： C12N15/113 , A01K67/0337 , A01K2217/05 , A01N57/16 , A61K31/713 , A61K38/00 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2320/32 , C12N2320/50 , C12Y302/01031
摘要： The invention is to methods of gene silencing in arthropods using dsRNA. The method is include contacting the arthropod with, and/or directly feeding the arthropod, the dsRNA to the arthropods to deliver the dsRNA to arthropod tissues. It is envisaged that the methods of the invention will have use in determining the biological function of genes in arthropods. Methods of pest control of arthropods, and of protecting arthropods against parasites and predators are provided. Transgenic arthropods expressing dsRNA molecules are also provided by the present invention.
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公开(公告)号：US08415320B2
公开(公告)日：2013-04-09
申请号：US13545604
申请日：2012-07-10
CPC分类号： C12N15/113 , A01K67/0337 , A01K2217/05 , A01N57/16 , A61K31/713 , A61K38/00 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2320/32 , C12N2320/50 , C12Y302/01031
摘要： The invention is to methods of gene silencing in arthropods using dsRNA. The method is include contacting the arthropod with, and/or directly feeding the arthropod, the dsRNA to the arthropods to deliver the dsRNA to arthropod tissues. It is envisaged that the methods of the invention will have use in determining the biological function of genes in arthropods. Methods of pest control of arthropods, and of protecting arthropods against parasites and predators are provided. Transgenic arthropods expressing dsRNA molecules are also provided by the present invention.
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