公开(公告)号：US4801617A

公开(公告)日：1989-01-31

申请号：US154267

申请日：1988-02-10

申请人： Gerard LeClerc ,  Didier Huber ,  Jacques Himber ,  Guy Andermann

发明人： Gerard LeClerc ,  Didier Huber ,  Jacques Himber ,  Guy Andermann

IPC分类号： C07D233/22 ,  C07D233/50 ,  A61K31/415

CPC分类号： C07D233/22 ,  C07D233/50

摘要： Antiglaucoma compounds having beta adrenoreceptor antagonist properties and alpha adrenoreceptor antagonist properties are described. The compounds comprise a beta blocker-derived moiety designed to provide beta antagonist properties and an imidazolidine moiety designed to provide alpha-antagonist properties. Methods of synthesizing the compounds are also described. The compounds are useful in the treatment of glaucoma due to their ability to lower elevated intraocular pressure.

摘要翻译： 描述了具有β肾上腺素受体拮抗剂特性和α肾上腺素受体拮抗剂性质的抗青光眼化合物。 该化合物包含设计用于提供β拮抗剂特性的β阻断剂衍生部分和设计用于提供α-拮抗剂性质的咪唑烷部分。 还描述了合成化合物的方法。 由于其降低眼内压升高的能力，这些化合物可用于治疗青光眼。

公开(公告)号：US4897412A

公开(公告)日：1990-01-30

申请号：US299273

申请日：1989-01-19

申请人： Gerard LeClerc ,  Didier Huber ,  Jacques Himber ,  Guy Andermann

发明人： Gerard LeClerc ,  Didier Huber ,  Jacques Himber ,  Guy Andermann

IPC分类号： C07D233/22 ,  C07D233/50

CPC分类号： C07D233/22 ,  C07D233/50

摘要： Antiglaucoma compounds having beta adrenoreceptor antagonist properties and alpha adrenoreceptor antagonist properties are described. The compounds comprise a beta blocker-derived moiety designed to provide beta antagonist properties and an imidazolidine moiety designed to provide alpha-antagonist properties. Methods of synthesizing the compounds are also described. The compounds are useful in the treatment of glaucoma due to their ability to lower elevated intraocular pressure.

摘要翻译： 描述了具有β肾上腺素受体拮抗剂特性和α肾上腺素受体拮抗剂性质的抗青光眼化合物。 该化合物包含设计用于提供β拮抗剂特性的β阻断剂衍生部分和设计用于提供α-拮抗剂性质的咪唑烷部分。 还描述了合成化合物的方法。 由于其降低眼内压升高的能力，这些化合物可用于治疗青光眼。

公开(公告)号：US4952573A

公开(公告)日：1990-08-28

申请号：US172047

申请日：1988-03-23

申请人： Gerard LeClerc ,  Beatrice Ruhland ,  Guy Andermann ,  Georges de Burlet ,  Michel Dietz

发明人： Gerard LeClerc ,  Beatrice Ruhland ,  Guy Andermann ,  Georges de Burlet ,  Michel Dietz

IPC分类号： C07D215/50 ,  C07D223/16 ,  C07D498/04

CPC分类号： C07D223/16 ,  C07D215/50

摘要： Compounds which enhance the efficiency of the corneal endothelial fluid pump thereby promoting normal corneal function and deturgescence of swollen corneas, and methods for the compounds' synthesis are described. In addition, surgical irrigating solutions which include one or more of the compounds are discussed along with methods for their use.

摘要翻译： 描述了提高角膜内皮液泵效率的化合物，从而促进角膜功能的正常作用和肿胀角膜的脱皮，以及化合物合成的方法。 此外，还讨论了包括一种或多种化合物的手术冲洗溶液及其使用方法。

公开(公告)号：US4330496A

公开(公告)日：1982-05-18

申请号：US173170

申请日：1980-07-28

申请人： Gerard Desplanches ,  Gerard LeClerc

发明人： Gerard Desplanches ,  Gerard LeClerc

IPC分类号： C04B35/113 ,  C04B35/64 ,  H01M10/39 ,  F27B9/14

CPC分类号： C04B35/113 ,  C04B35/64 ,  H01M10/3918 ,  Y10T428/131

摘要： A tubular ceramic part is formed with a shoulder at an open end of the part, the tubular part is inserted in an opening provided in a horizontal plate which is disposed inside a sintering chamber so that the part is kept suspended in the chamber by means of the shoulder which rests against the edge of the opening, a shouldered cylindrical plug is inserted into the open end of the tubular part until the shoulder of the plug bears against the end of the tubular part, and the chamber is brought to sintering temperature. The invention is implemented to produce solid beta sodium alumina electrolyte tubes for sodium-sulphur electric cells.

摘要翻译： 管状陶瓷部件在部件的开口端形成有肩部，管状部分插入设置在水平板中的开口中，该开口设置在烧结室内部，使得部件通过 靠在开口边缘的肩部，一个肩部圆柱形插头插入到管状部分的开口端，直到插头的肩部靠在管状部件的端部上，并使该腔体达到烧结温度。 实施本发明以生产用于钠硫电池的固体β型氧化钠电解质管。

公开(公告)号：US5760645A

公开(公告)日：1998-06-02

申请号：US744146

申请日：1996-11-12

申请人： Michel Comte ,  Gerard LeClerc

发明人： Michel Comte ,  Gerard LeClerc

IPC分类号： H04L27/22 ,  H03D3/00 ,  H04L27/227

CPC分类号： H04L27/22

摘要： A demodulator stage for direct demodulation of a phase quadrature modulated signal provides two baseband signals and comprises a matched 900.degree. coupler to which the modulated signal is fed and supplying two phase quadrature modulated signals. Two low-noise amplifiers with identical specifications each receive one of the phase quadrature modulated signals and supply an amplified signal. Two mixers each receive one of the amplified signals and a common local oscillator signal and supply the baseband signals. The 90.degree. coupler, the low-noise amplifiers and the two mixers can be integrated into the same MMIC. One application is to a receiver for frequency evasive phase quadrature modulated signals.

摘要翻译： 用于相位正交调制信号的直接解调的解调器级提供两个基带信号，并且包括匹配的900°耦合器，调制信号被馈送到其中并提供两相正交调制信号。 具有相同规格的两个低噪声放大器均接收相位正交调制信号之一并提供放大信号。 两个混频器各接收一个放大信号和一个公共本地振荡器信号，并提供基带信号。 90°耦合器，低噪声放大器和两个混频器可以集成到同一个MMIC中。 一种应用是用于频率回避相位正交调制信号的接收机。