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公开(公告)号：US06426357B1
公开(公告)日：2002-07-30
申请号：US09629180
申请日：2000-07-31
申请人： Randall A. Scheuerman , Stephen D. Yanofsky , Christopher P. Holmes , Derek MacLean , Beatrice Ruhland , Ronald W. Barrett , Jay E. Wrobel , Ariamala Gopalsamy
发明人： Randall A. Scheuerman , Stephen D. Yanofsky , Christopher P. Holmes , Derek MacLean , Beatrice Ruhland , Ronald W. Barrett , Jay E. Wrobel , Ariamala Gopalsamy
IPC分类号： A61K31427
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention provides a compound of the formula: and methods for using the same, wherein R1, R2, R3, R4 and X are those defined herein.
摘要翻译： 本发明提供下式的化合物及其使用方法：其中R1，R2，R3，R4和X为本文定义的化合物。
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2.发明授权Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 失效结合选择素的肽和化合物，包括内皮细胞粘附分子1
公开(公告)号：US5786322A
公开(公告)日：1998-07-28
申请号：US485508
申请日：1995-06-07
申请人： Ronald W. Barrett , Steven E. Cwirla , William J. Dower , Kerry J. Koller , Jung Lee , Christine L. Martens , Beatrice Ruhland-Fritsch
发明人： Ronald W. Barrett , Steven E. Cwirla , William J. Dower , Kerry J. Koller , Jung Lee , Christine L. Martens , Beatrice Ruhland-Fritsch
IPC分类号： A61K38/00 , A61K47/48 , A61K49/00 , A61K51/08 , C07K1/04 , C07K7/06 , C07K7/08 , C07K14/00 , C07K5/00 , C07K7/00 , C07K16/00
CPC分类号： A61K49/0056 , A61K47/48238 , A61K51/08 , C07K1/047 , C07K14/001 , C07K7/06 , C07K7/08 , A61K2123/00 , A61K38/00
摘要： Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking adhesion of leukocytes to the selectins for the purpose of inhibiting inflammation as well as in diagnostic methods employing labeled peptides and peptide mimetics that bind selectins for the purpose of determining the site of inflammation in mammals which inflammation is mediated by the presence of one or more selectins.
摘要翻译： 公开了结合选择蛋白的肽和肽模拟物，包括内皮细胞粘附分子1（ELAM-1）。 这样的肽和肽模拟物可用于阻止白细胞粘附到选择素上用于抑制炎症的方法以及使用结合选择素的标记肽和肽模拟物的诊断方法，以确定哺乳动物的炎症位点 炎症由一种或多种选择素的存在介导。
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3.发明授权Peptides and compounds that bind selectins including endothelium leukocyte adhesion molecule 1 (ELAM-1) 失效结合选择素的肽和化合物，包括内皮细胞粘附分子1（ELAM-1）
公开(公告)号：US5728802A
公开(公告)日：1998-03-17
申请号：US439817
申请日：1995-05-12
申请人： Ronald W. Barrett , Steven E. Cwirla , William J. Dower , Kerry J. Koller , Jung Lee , Christine L. Martens , Beatrice Ruhland
发明人： Ronald W. Barrett , Steven E. Cwirla , William J. Dower , Kerry J. Koller , Jung Lee , Christine L. Martens , Beatrice Ruhland
CPC分类号： A61K51/08 , A61K47/48238 , A61K49/0056 , C07K1/047 , C07K14/001 , C07K7/06 , C07K7/08 , A61K2123/00 , A61K38/00
摘要： Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking adhesion of leukocytes to the selectins for the purpose of inhibiting inflammation as well as in diagnostic methods employing labeled peptides and peptide mimetics that bind selectins for the purpose of determining the site of inflammation in mammals which inflammation is mediated by the presence of one or more selectins.
摘要翻译： 公开了结合选择素的肽和肽模拟物，包括内皮细胞粘附分子1（ELAM-1）。 这样的肽和肽模拟物可用于阻止白细胞粘附到选择素上用于抑制炎症的方法以及使用结合选择素的标记肽和肽模拟物的诊断方法，以确定哺乳动物的炎症位点 炎症由一种或多种选择素的存在介导。
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4.发明授权Compounds having GABA like activity, and use of same in tissue irrigating solutions 失效具有GABA活性的化合物，以及在组织冲洗溶液中的用途
公开(公告)号：US4952573A
公开(公告)日：1990-08-28
申请号：US172047
申请日：1988-03-23
IPC分类号： C07D215/50 , C07D223/16 , C07D498/04
CPC分类号： C07D223/16 , C07D215/50
摘要： Compounds which enhance the efficiency of the corneal endothelial fluid pump thereby promoting normal corneal function and deturgescence of swollen corneas, and methods for the compounds' synthesis are described. In addition, surgical irrigating solutions which include one or more of the compounds are discussed along with methods for their use.
摘要翻译： 描述了提高角膜内皮液泵效率的化合物，从而促进角膜功能的正常作用和肿胀角膜的脱皮，以及化合物合成的方法。 此外，还讨论了包括一种或多种化合物的手术冲洗溶液及其使用方法。
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5.发明授权Peptides and compounds that bind selectins including endothelial leukocyte adhesion molecule 1 失效结合选丝素的肽和化合物，包括内皮细胞粘附分子1
公开(公告)号：US5643873A
公开(公告)日：1997-07-01
申请号：US241054
申请日：1994-05-11
申请人： Ronald W. Barrett , Steven E. Cwirla , William J. Dower , Kerry J. Koller , Jung Lee , Christine L. Martens , Beatrice Ruhland-Fritsch
发明人： Ronald W. Barrett , Steven E. Cwirla , William J. Dower , Kerry J. Koller , Jung Lee , Christine L. Martens , Beatrice Ruhland-Fritsch
CPC分类号： A61K49/0056 , A61K47/48238 , A61K51/08 , C07K1/047 , C07K14/001 , C07K7/06 , C07K7/08 , A61K2123/00 , A61K38/00
摘要： Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking adhesion of leukocytes to the selectins for the purpose of inhibiting inflammation as well as in diagnostic methods employing labeled peptides and peptide mimetics that bind selectins for the purpose of determining the site of inflammation in mammals which inflammation is mediated by the presence of one or more selectins.
摘要翻译： 公开了结合选择素的肽和肽模拟物，包括内皮细胞粘附分子1（ELAM-1）。 这样的肽和肽模拟物可用于阻止白细胞粘附到选择素上用于抑制炎症的方法以及使用结合选择素的标记肽和肽模拟物的诊断方法，以确定哺乳动物的炎症位点 炎症由一种或多种选择素的存在介导。
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6.发明授权Acyclic purine phosphonate nucleotide analogs as antiviral agents, and related synthetic methods 失效作为抗病毒药物的非循环嘌呤膦酸酯核苷酸类似物，以及相关的合成方法
公开(公告)号：US5532225A
公开(公告)日：1996-07-02
申请号：US922937
申请日：1992-07-31
IPC分类号： C07F9/6561 , C07F9/6571 , A61K31/675 , C07F9/6512
CPC分类号： C07F9/657181 , C07F9/65616
摘要： Acyclic purine phosphonate nucleotide analogs useful to treat herpes viral infections are provided in enantiomerically pure form. These antiviral agents have the structural formula (Ia) or (Ib) ##STR1## and may be in acid, salt or ester form. Such compounds may also be dehydrated to provide antiviral agents in cyclic form. Pharmaceutical compositions are provided containing the antiviral agents, as is a chiral synthesis which may be used to prepare the agents in enantiomerically pure form or as a racemic mixture.
摘要翻译： 用于治疗疱疹病毒感染的非环嘌呤膦酸酯核苷酸类似物以对映体纯的形式提供。 这些抗病毒剂具有结构式（Ia）或（Ib）（Ia）（Ib），并且可以是酸，盐或酯形式。 这些化合物也可以脱水以提供环状抗病毒剂。 提供含有抗病毒剂的药物组合物，手性合成也可以以对映异构体纯形式或作为外消旋混合物制备。
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