专利检索 ap:("Gerd Pluschke" OR "Ursula Kienl" OR "John Robinson" OR "Rinaldo Zurbriggen") AND inv:"Ursula Kienl" 第 1 页

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发明申请
Method for synthesizing conformationally constrained peptides, peptidomimetics and the use thereof as synthetic vaccines 失效

公开(公告)号：US20060258564A1

公开(公告)日：2006-11-16

申请号：US10559010

申请日：2004-06-02

申请人： Gerd Pluschke , Ursula Kienl , John Robinson , Rinaldo Zurbriggen

发明人： Gerd Pluschke , Ursula Kienl , John Robinson , Rinaldo Zurbriggen

IPC分类号： A61K38/12 , C07K7/64

CPC分类号： G01N33/56911 , A61K38/00 , A61K39/00 , A61K39/015 , C07K7/56 , C07K16/205 , Y02A50/412 , Y02A50/58

摘要： The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S, 4S)4-functionalized proline residue. The invention further relates to the use of (2S, 4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same.