公开(公告)号：US06172050B2

公开(公告)日：2001-01-09

申请号：US08905333

申请日：1997-08-04

申请人： Gerhard Nössner ,  Bernhard Kutscher ,  J{umlaut over (u)}rgen Engel ,  Wolfgang Schumacher ,  Jurij Stekar ,  Peter Hilgard

发明人： Gerhard Nössner ,  Bernhard Kutscher ,  J{umlaut over (u)}rgen Engel ,  Wolfgang Schumacher ,  Jurij Stekar ,  Peter Hilgard

IPC分类号： A61K31675

CPC分类号： A61K31/675 ,  A61K31/452 ,  C07F9/5532 ,  C07F9/572 ,  C07F9/59 ,  C07F9/6561 ,  Y02A50/409

摘要： Phospholipid derivatives of Formula X: wherein A is the ring system in which R is a linear or branched alkyl radical having 10 to 24 carbon atoms which may contain one or more double or triple bonds; R1 and R2 are independently hydrogen or linear alkyl radicals having 1 to 3 carbon atoms; y is 0, 1, 2 or 3; m and n are independently 0 or in an integer, with the proviso that m+n is between 2 and 8; or A is a tropanio or quinuclidinio ring system, which is linked via a carbon-carbon bond and is optionally substituted by one or more methyl groups; processes for the preparation of the derivatives, and methods for treating tumors therewith.

摘要翻译： 式X的磷脂衍生物：其中A是环系，其中R是具有10至24个碳原子的直链或支链烷基，其可以含有一个或多个双键或三键; R1和R2独立地是氢或具有1至3个碳原子的直链烷基; y为0,1,2或3; m和n独立地为0或整数，条件是m + n在2和8之间; 或A是通过碳 - 碳键连接并且任选地被一个或多个甲基取代的托普拉尼或奎宁环系统; 衍生物的制备方法，以及用于治疗肿瘤的方法。