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    Device for treating pieces of a substrate at high pressure with a supercritical or near-critical treatment medium, piece by piece or in batches
    2.
    发明授权
    Device for treating pieces of a substrate at high pressure with a supercritical or near-critical treatment medium, piece by piece or in batches 有权
    用于用超临界或近临界处理介质逐个或分批地处理高压基片的装置

    公开(公告)号：US07861733B2

    公开(公告)日：2011-01-04

    申请号：US11327927

    申请日：2006-01-09

    申请人： Hubert Clemens Pellikaan ,  Geert Feye Woerlee

    发明人： Hubert Clemens Pellikaan ,  Geert Feye Woerlee

    IPC分类号： B08B3/04

    CPC分类号： D06F43/02

    摘要： A device for treating pieces of a substrate at high pressure, piece by piece or in batches, with a treatment medium in the supercritical or near-critical state, includes a first pressure chamber, a pipe system for supplying and discharging the treatment medium, to and from the pressure chamber under high pressure and an electric motor, which is fixed to the housing in the first pressure chamber or in a second pressure chamber coupled to the first pressure chamber under the high pressure, for driving an actuator to carry out a mechanical action in the treatment medium. The electric motor is in this case open to the treatment medium and is disposed and designed to be accessible to the treatment medium, in such a manner that during the treatment of a substrate the treatment medium flows through and around the electric motor.

    摘要翻译： 一种处理介质处于超临界状态或接近临界状态的用于高压，逐件或分批处理基片的装置包括：第一压力室，用于供给和排出处理介质的管道系统， 以及在高压下的压力室和电动机，其被固定到第一压力室中的壳体或在高压下联接到第一压力室的第二压力室中，用于驱动致动器以执行机械 在治疗介质中的作用。 在这种情况下，电动机对处理介质是开放的，并且被设置和设计成能够被处理介质访问，使得在处理基板期间处理介质流过电动机周围。

    Sterile alginate-based aqueous composition for medical use and process for the preparation thereof
    3.
    发明授权
    Sterile alginate-based aqueous composition for medical use and process for the preparation thereof 有权
    用于医疗用途的无菌藻酸盐水性组合物及其制备方法

    公开(公告)号：US08927524B2

    公开(公告)日：2015-01-06

    申请号：US13583912

    申请日：2011-03-08

    申请人： Johannes Caspar Mathias Elizabeth Bender ,  Hubert Clemens Pellikaan

    发明人： Johannes Caspar Mathias Elizabeth Bender ,  Hubert Clemens Pellikaan

    IPC分类号： A61K31/734 ,  A61K9/00 ,  A61K47/02 ,  A61K47/36

    CPC分类号： A61K31/734 ,  A61K9/0024 ,  A61K47/02 ,  A61K47/36

    摘要： The present invention relates to ready-to-use sterile, alginate-based, aqueous compositions for medical use. More particularly, the invention relates to an aqueous composition for medical use that has been sterilized by heat sterilization and having a viscosity at 25° C. of at least 300 cP) (Helipath® T F spindle, 100 rpm at 25° C.), said composition having a pH in the range of 6.5-7.5; containing 0.5-10 wt. % of an alginate salt; and further containing 10-500 mM of one or more dissolved C2-C7 mono- or dicarboxylates that are optionally substituted with up to 2 hydroxyl groups.The alginate-based composition of the present invention has excellent storage stability and is easy to manufacture. The alginate-based aqueous compositions of the present invention can advantageously be used, for instance, to prevent adhesions between a healing trauma site and adjacent surrounding tissue. These compositions can further be used in implants or in pharmaceutical preparations for oral administration.

    摘要翻译： 本发明涉及用于医疗用途的即用型无菌藻酸盐基水性组合物。 更具体地说，本发明涉及一种医疗用水性组合物，其通过热灭菌消毒，并且在25℃下的粘度为至少300cP）（Helipath TF芯轴，25℃下100rpm）， 所述组合物的pH在6.5-7.5的范围内; 含0.5-10wt。 ％的藻酸盐; 并进一步含有10-500mM的一个或多个可任选被至多2个羟基取代的C 2 -C 7单羧酸或C 1 -C 7羧酸酯。 本发明的基于藻酸盐的组合物具有优异的储存稳定性，易于制造。 本发明的藻酸盐基水性组合物可以有利地用于例如防止愈合创伤部位和相邻的周围组织之间的粘连。 这些组合物还可以用于植入物或用于口服给药的药物制剂中。

    STERILE ALGINATE-BASED AQUEOUS COMPOSITION FOR MEDICAL USE AND PROCESS FOR THE PREPARATION THEREOF
    4.
    发明申请
    STERILE ALGINATE-BASED AQUEOUS COMPOSITION FOR MEDICAL USE AND PROCESS FOR THE PREPARATION THEREOF 有权
    用于医疗用途的基于ALT的碱性水性组合物及其制备方法

    公开(公告)号：US20130096080A1

    公开(公告)日：2013-04-18

    申请号：US13583912

    申请日：2011-03-08

    申请人： Johannes Caspar Mathias Elizabeth Bender ,  Hubert Clemens Pellikaan

    发明人： Johannes Caspar Mathias Elizabeth Bender ,  Hubert Clemens Pellikaan

    IPC分类号： A61K31/734

    CPC分类号： A61K31/734 ,  A61K9/0024 ,  A61K47/02 ,  A61K47/36

    摘要： The present invention relates to ready-to-use sterile, alginate-based, aqueous compositions for medical use. More particularly, the invention relates to an aqueous composition for medical use that has been sterilized by heat sterilization and having a viscosity at 25° C. of at least 300 cP) (Helipath® T F spindle, 100 rpm at 25° C.), said composition having a pH in the range of 6.5-7.5; containing 0.5-10 wt. % of an alginate salt; and further containing 10-500 mM of one or more dissolved C2-C7 mono- or dicarboxylates that are optionally substituted with up to 2 hydroxyl groups.The alginate-based composition of the present invention has excellent storage stability and is easy to manufacture. The alginate-based aqueous compositions of the present invention can advantageously be used, for instance, to prevent adhesions between a healing trauma site and adjacent surrounding tissue. These compositions can further be used in implants or in pharmaceutical preparations for oral administration.

    摘要翻译： 本发明涉及用于医疗用途的即用型无菌，藻酸盐基水性组合物。 更具体地说，本发明涉及一种医疗用水性组合物，其通过热灭菌消毒，并且在25℃下的粘度为至少300cP）（Helipath TF芯轴，25℃下100rpm）， 所述组合物的pH在6.5-7.5的范围内; 含0.5-10wt。 ％的藻酸盐; 并进一步含有10-500mM的一个或多个可任选被至多2个羟基取代的C 2 -C 7单羧酸或C 1 -C 7羧酸酯。 本发明的基于藻酸盐的组合物具有优异的储存稳定性，易于制造。 本发明的藻酸盐基水性组合物可以有利地用于例如防止愈合创伤部位和相邻的周围组织之间的粘连。 这些组合物还可以用于植入物或用于口服给药的药物制剂中。

    DOSAGE UNIT FOR SUBLINGUAL, BUCCAL OR ORAL ADMINISTRATION OF WATER-INSOLUBLE PHARMACEUTICALLY ACTIVE SUBSTANCES
    5.
    发明申请
    DOSAGE UNIT FOR SUBLINGUAL, BUCCAL OR ORAL ADMINISTRATION OF WATER-INSOLUBLE PHARMACEUTICALLY ACTIVE SUBSTANCES 有权
    剂量单位用于水不溶性药物活性物质的分类，结构或口服施用

    公开(公告)号：US20100008985A1

    公开(公告)日：2010-01-14

    申请号：US12441342

    申请日：2007-09-14

    申请人： Hubert Clemens Pellikaan ,  Pieter Sebastiaan Vermeulen ,  Johannes Caspar Mathias Elizabeth Bender ,  Geert Feye Woerlee

    发明人： Hubert Clemens Pellikaan ,  Pieter Sebastiaan Vermeulen ,  Johannes Caspar Mathias Elizabeth Bender ,  Geert Feye Woerlee

    IPC分类号： A61K31/352 ,  A61K9/10 ,  A61K9/26 ,  A61P25/28

    CPC分类号： A61K9/2077 ,  A61K9/0056

    摘要： One aspect of the invention relates to a pharmaceutical dosage unit for sublingual, buccal, pulmonary or oral administration, said dosage unit having a weight of 20-500 mg and comprising 1-80 Wt. % of a microgranulate that is distributed throughout a solid hydrophilic matrix; said microgranulate being characterised in that it: has a volume weighted average diameter of 5-100 m; contains at least 0.01 wt. %, preferably at least 0.1 wt. % of one or more water-insoluble pharmaceutically active substances; contains at least 10 wt. %, preferably at least 20 wt. % of an emulsifier component; and is capable of forming a micro-emulsion upon contact with saliva or water. The dosage units of the present invention achieve the inherent benefits of oral delivery whilst at the same time realising a high transmucosal absorption rate of the cannabinoids contained therein. Other aspects of the present invention relate to the use of the aforementioned dosage units in the therapeutic or prophylactic treatment and to a process for the manufacture of said dosage units.

    摘要翻译： 本发明的一个方面涉及用于舌下，口腔，肺或口服给药的药物剂量单位，所述剂量单位的重量为20-500mg，包含1-80Wt。 分布在整个固体亲水基质中的微粒的％; 所述微粒的特征在于：具有5-100μm的体积加权平均直径; 含有至少0.01重量％ ％，优选至少0.1wt。 ％的一种或多种水不溶性药物活性物质; 含有至少10重量％ ％，优选至少20wt。 ％的乳化剂组分; 并且能够在与唾液或水接触时形成微乳液。 本发明的剂量单位实现口服递送的固有益处，同时实现其中所含的大麻素的高透粘膜吸收速率。 本发明的其它方面涉及上述剂量单位在治疗或预防治疗中的用途以及制备所述剂量单位的方法。

    Dosage unit for sublingual, buccal or oral administration of water-insoluble pharmaceutically active substances
    6.
    发明授权
    Dosage unit for sublingual, buccal or oral administration of water-insoluble pharmaceutically active substances 有权
    用于舌下，口腔或口服不溶性药物活性物质的剂量单位

    公开(公告)号：US09308175B2

    公开(公告)日：2016-04-12

    申请号：US12441342

    申请日：2007-09-14

    申请人： Hubert Clemens Pellikaan ,  Pieter Sebastiaan Vermeulen ,  Johannes Caspar Mathias Elizabeth Bender ,  Geert Feye Woerlee

    发明人： Hubert Clemens Pellikaan ,  Pieter Sebastiaan Vermeulen ,  Johannes Caspar Mathias Elizabeth Bender ,  Geert Feye Woerlee

    IPC分类号： A61K9/10 ,  A61K9/26 ,  A61K9/20 ,  A61K9/00

    CPC分类号： A61K9/2077 ,  A61K9/0056

    摘要： One aspect of the invention relates to a pharmaceutical dosage unit for sublingual, buccal, pulmonary or oral administration, said dosage unit having a weight of 20-500 mg and comprising 1-80 wt. % of a microgranulate that is distributed throughout a solid hydrophilic matrix; said microgranulate being characterized in that it: has a volume weighted average diameter of 5-100 m; contains at least 0.01 wt. %, preferably at least 0.1 wt. % of one or more water-insoluble pharmaceutically active substances; contains at least 10 wt. %, preferably at least 20 wt. % of an emulsifier component; and is capable of forming a micro-emulsion upon contact with saliva or water. The dosage units of the present invention achieve the inherent benefits of oral delivery while at the same time realizing a high transmucosal absorption rate of the cannabinoids contained therein. Other aspects of the present invention relate to the use of the aforementioned dosage units in the therapeutic or prophylactic treatment and to a process for the manufacture of said dosage units.

    摘要翻译： 本发明的一个方面涉及舌下，口腔，肺或口服给药的药物剂量单位，所述剂量单位的重量为20-500mg，包含1-80wt。 分布在整个固体亲水基质中的微粒的％; 所述微粒的特征在于：具有5-100μm的体积加权平均直径; 含有至少0.01重量％ ％，优选至少0.1wt。 ％的一种或多种水不溶性药物活性物质; 含有至少10重量％ ％，优选至少20wt。 ％的乳化剂组分; 并且能够在与唾液或水接触时形成微乳液。 本发明的剂量单位实现口服递送的固有益处，同时实现其中所含的大麻素的高粘膜吸收率。 本发明的其它方面涉及上述剂量单位在治疗或预防治疗中的用途以及制备所述剂量单位的方法。