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![2-heteroaryl-pyrrolo[3,4-c]pyrrole derivatives and their use as SCD inhibitors](/abs-image/US/2011/08/23/US08003677B2/abs.jpg.150x150.jpg)
1.发明授权2-heteroaryl-pyrrolo[3,4-c]pyrrole derivatives and their use as SCD inhibitors 有权2-杂芳基 - 吡咯并[3,4-c]吡咯衍生物及其作为SCD抑制剂的用途公开(公告)号：US08003677B2
公开(公告)日：2011-08-23
申请号：US12605631
申请日：2009-10-26
IPC分类号： A61K31/426
CPC分类号： C07D487/04
摘要： The invention relates to heterocyclic derivatives of formula I wherein R, R1, A, B, D, M, L and n are as defined herein, or their physiologically compatible salts, their pharmaceutical compositions and their uses as SCD1 inhibitors.
摘要翻译： 本发明涉及式I的杂环衍生物，其中R，R 1，A，B，D，M，L和n如本文所定义，或其生理上相容的盐，其药物组合物及其作为SCD1抑制剂的用途。
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![2-HETEROARYL-PYRROLO[3,4-C]PYRROLE DERIVATIVES AND THEIR USE AS SCD](/abs-image/US/2011/10/06/US20110245263A1/abs.jpg.150x150.jpg)
2.发明申请2-HETEROARYL-PYRROLO[3,4-C]PYRROLE DERIVATIVES AND THEIR USE AS SCD 审中-公开2-异丙基吡咯并[3,4-C]吡咯并吡喃衍生物及其作为SCD公开(公告)号：US20110245263A1
公开(公告)日：2011-10-06
申请号：US13160705
申请日：2011-06-15
IPC分类号： A61K31/501 , C07D487/04 , A61K31/506 , A61K31/4439 , A61P9/00 , A61P25/00 , A61P3/10 , A61P3/04 , A61K31/427 , A61K31/517 , A61P3/00 , A61P25/28 , A61P25/18
CPC分类号： C07D487/04
摘要： The invention relates to heterocyclic derivatives of formula I wherein R, R1, A, B, D, M, L and n are as defined herein, or their physiologically compatible salts, their pharmaceutical compositions and their uses as SCD1 inhibitors.
摘要翻译： 本发明涉及式I的杂环衍生物，其中R，R 1，A，B，D，M，L和n如本文所定义，或其生理上相容的盐，其药物组合物及其作为SCD1抑制剂的用途。
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![2-heteroaryl-pyrrolo [3,4-C]pyrrole derivatives, and use thereof as SCD inhibitors](/abs-image/US/2014/03/18/US08673917B2/abs.jpg.150x150.jpg)
3.发明授权2-heteroaryl-pyrrolo [3,4-C]pyrrole derivatives, and use thereof as SCD inhibitors 有权2-杂芳基 - 吡咯并[3,4-C]吡咯衍生物及其作为SCD抑制剂的用途公开(公告)号：US08673917B2
公开(公告)日：2014-03-18
申请号：US13063088
申请日：2009-09-02
IPC分类号： C07D401/14 , A61K31/4402 , A61K31/501 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/00
CPC分类号： C07D487/04
摘要： The invention relates to compounds of the formula (I), where the groups R1, M, A, B, D, L, and R have the specified meanings, and to the physiologically compatible salts thereof. The compounds are suitable, for example, for treating metabolic syndrome, insulin resistance, obesity, and diabetes.
摘要翻译： 本发明涉及式（I）化合物，其中基团R 1，M，A，B，D，L和R具有特定含义，以及其生理上相容的盐。 该化合物适用于例如治疗代谢综合征，胰岛素抵抗，肥胖症和糖尿病。
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![2-HETEROARYL-PYRROLO [3,4-C]PYRROLE DERIVATIVES, AND USE THEREOF AS SCD INHIBITORS](/abs-image/US/2012/02/02/US20120028986A1/abs.jpg.150x150.jpg)
4.发明申请2-HETEROARYL-PYRROLO [3,4-C]PYRROLE DERIVATIVES, AND USE THEREOF AS SCD INHIBITORS 有权2-异丙基 - 吡咯并[3,4-C]吡咯烷酮衍生物及其作为SCD抑制剂的用途公开(公告)号：US20120028986A1
公开(公告)日：2012-02-02
申请号：US13063088
申请日：2009-09-02
IPC分类号： A61K31/501 , A61K31/4439 , A61P3/06 , A61P9/10 , A61P35/00 , A61P1/04 , A61P29/00 , A61P25/16 , A61P25/28 , A61P17/10 , A61P17/00 , A61P31/20 , A61P3/04 , A61P11/06 , A61P19/02 , A61P19/06 , A61P31/12 , A61P21/00 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to compounds of the formula (I), where the groups R1, M, A, B, D, L, and R have the specified meanings, and to the physiologically compatible salts thereof. The compounds are suitable, for example, for treating metabolic syndrome, insulin resistance, obesity, and diabetes.
摘要翻译： 本发明涉及式（I）化合物，其中基团R 1，M，A，B，D，L和R具有特定含义，以及其生理上相容的盐。 该化合物适用于例如治疗代谢综合征，胰岛素抵抗，肥胖症和糖尿病。
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公开(公告)号：US20080249011A1
公开(公告)日：2008-10-09
申请号：US11908065
申请日：2006-03-06
CPC分类号： G01N33/566
摘要： The invention concerns the use of MGC4504 protein, a functional derivative or fragment thereof, or a nucleic acid coding for said protein, derivative or fragment, for the identification of substances active in preventing or treating a disease associated with or caused by a malfunction of the carbohydrate or lipid metabolism.
摘要翻译： 本发明涉及使用MGC4504蛋白，其功能性衍生物或其片段，或编码所述蛋白质，衍生物或片段的核酸来鉴定活性物质，用于预防或治疗与 碳水化合物或脂质代谢。
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