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公开(公告)号：US08222242B2
公开(公告)日：2012-07-17
申请号：US12595799
申请日：2008-04-10
申请人： Gerry R. Boss , Vijay Sharma , Kate E. Broderick
发明人： Gerry R. Boss , Vijay Sharma , Kate E. Broderick
IPC分类号： A01N55/02 , A61K31/555 , C07B47/00 , C07D487/22
CPC分类号： A61K31/555
摘要： Compositions comprising nitrosyl-cobinamide are provided. Also provided are methods for treating hypertension, which comprise administering therapeutically effective amounts of nitrosyl-cobinamide. Also provided are methods for producing nitrosyl-cobinamide.
摘要翻译： 提供了包含亚硝酰基 - 叠氮酰胺的组合物。 还提供了治疗高血压的方法，其包括施用治疗有效量的亚硝酰基 - 叠氮胺。 还提供了生产亚硝酰基 - 叠氮酰胺的方法。
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公开(公告)号：US20100152153A1
公开(公告)日：2010-06-17
申请号：US12595799
申请日：2008-04-10
申请人： Gerry R. Boss , Vijay Sharma , Kate E. Broderick
发明人： Gerry R. Boss , Vijay Sharma , Kate E. Broderick
IPC分类号： A61K31/555 , A61P9/12 , C07F15/06
CPC分类号： A61K31/555
摘要： Compositions comprising nitrosyl-cobinamide are provided. Also provided are methods for treating hypertension, which comprise administering therapeutically effective amounts of nitrosyl-cobinamide. Also provided are methods for producing nitrosyl-cobinamide.
摘要翻译： 提供了包含亚硝酰基 - 叠氮酰胺的组合物。 还提供了治疗高血压的方法，其包括施用治疗有效量的亚硝酰基 - 叠氮胺。 还提供了生产亚硝酰基 - 叠氮酰胺的方法。
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3.发明授权Methods and compositions for treatment of excess nitric oxide or cyanide toxicity 有权治疗过量一氧化氮或氰化物毒性的方法和组合物公开(公告)号：US08431561B2
公开(公告)日：2013-04-30
申请号：US11630049
申请日：2005-06-17
申请人： Gerry Boss , Vijay Sharma , Kate E. Broderick
发明人： Gerry Boss , Vijay Sharma , Kate E. Broderick
IPC分类号： A61K31/555 , A61K31/70
CPC分类号： A61K31/70
摘要： Methods for treating disease states in a subject caused or exacerbated by the presence of excess nitric oxide (NO) or excess cyanide are provided. Methods for alleviating the symptoms of a disease state in a subject caused or exacerbated by the presence of excess nitric oxide (NO) or excess cyanide in the subject are also provided. Pharmaceutical compositions comprising cobinamide and a pharmaceutically acceptable carrier are also provided.
摘要翻译： 提供了通过过量一氧化氮（NO）或过量氰化物的存在来治疗受试者的疾病状态引起或加剧的方法。 还提供了减轻受试者中过量一氧化氮（NO）或过量氰化物的存在引起或加剧的受试者疾病状态症状的方法。 还提供了包含联苯胺酰胺和药学上可接受的载体的药物组合物。
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4.发明申请Methods and Compositions for Treatment of Excess Nitric Oxide or Cyanide Toxicity 有权用于治疗过量一氧化氮或氰化物毒性的方法和组合公开(公告)号：US20080227746A1
公开(公告)日：2008-09-18
申请号：US11630049
申请日：2005-06-17
申请人： Gerry Boss , Vijay Sharama , Kate E. Broderick
发明人： Gerry Boss , Vijay Sharama , Kate E. Broderick
IPC分类号： A61K31/714 , A61K31/555 , C07F15/06 , A61P1/16
CPC分类号： A61K31/70
摘要： Methods for treating disease states in a subject caused or exacerbated by the presence of excess nitric oxide (NO) or excess cyanide are provided. Methods for alleviating the symptoms of a disease state in a subject caused or exacerbated by the presence of excess nitric oxide (NO) or excess cyanide in the subject are also provided. Pharmaceutical compositions comprising cobinamide and a pharmaceutically acceptable carrier are also provided.
摘要翻译： 提供了通过过量一氧化氮（NO）或过量氰化物的存在来治疗受试者的疾病状态引起或加剧的方法。 还提供了减轻受试者中过量一氧化氮（NO）或过量氰化物的存在引起或加剧的受试者疾病状态症状的方法。 还提供了包含联苯胺酰胺和药学上可接受的载体的药物组合物。
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