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    Method and apparatus for rapidly counting and identifying biological particles in a flow stream
    3.
    发明授权
    Method and apparatus for rapidly counting and identifying biological particles in a flow stream 失效
    用于在流动流中快速计数和识别生物颗粒的方法和装置

    公开(公告)号：US08159670B2

    公开(公告)日：2012-04-17

    申请号：US12262431

    申请日：2008-10-31

    申请人： Giacomo Vacca ,  Richard G. Kendall ,  Norman R. Goldblatt ,  Michael W. Yee ,  Mahesh R. Junnarkar

    发明人： Giacomo Vacca ,  Richard G. Kendall ,  Norman R. Goldblatt ,  Michael W. Yee ,  Mahesh R. Junnarkar

    IPC分类号： G01N21/00

    CPC分类号： G01N15/1434 ,  G01N1/38 ,  G01N15/1425 ,  G01N15/1459 ,  G01N2015/0065 ,  G01N2015/1402 ,  G01N2015/1447 ,  G01N2015/1486

    摘要： A method for increasing the throughput, or the precision, or both the precision and the throughput, of a flow cytometer, or of a hematology analyzer employing a flow cytometer, and for further reducing the complexity of such a cytometer or analyzer, by utilizing the technique of laser rastering in combination with a lysis-free single-dilution method. Laser rastering involves sweeping a laser beam across a flowing sample stream in a hematology analyzer. A lysis-free single-dilution method involves performing all the flow cytometer measurements on a sample using a single aliquot, a single lysis-free reagent solution, a single dilution, and a single pass of said dilution through the measurement apparatus. An apparatus suitable for carrying out the method of this invention comprises an optical module comprising a source of light, a scanning device, a lens or system of lenses, a flowcell, detectors, and filters; and an electronic module comprising preamplifiers, analog signal conditioning elements, analog-to-digital converters, field-programmable gate arrays, digital signal processing elements, and data storage elements.

    摘要翻译： 一种用于增加流式细胞仪或使用流式细胞仪的血液分析仪的吞吐量或精度或精度或者吞吐量的方法，并且为了进一步降低这种细胞仪或分析仪的复杂性，通过利用 激光扫描技术与无裂解单稀释法结合使用。 激光扫描涉及通过血液分析仪中的流动样品流扫描激光束。 无裂解的单次稀释法包括使用单次等分试样，单次无裂解试剂溶液，单一稀释液和通过测量装置的所述稀释液单次进行样品上的所有流式细胞仪测量。 适用于实施本发明方法的装置包括一个包括光源的光学模块，一个扫描装置，一个透镜或透镜系统，一个流通池，检测器和过滤器; 以及包括前置放大器，模拟信号调节元件，模拟 - 数字转换器，现场可编程门阵列，数字信号处理元件和数据存储元件的电子模块。

    METHOD AND APPARATUS FOR RAPIDLY COUNTING AND IDENTIFYING BIOLOGICAL PARTICLES IN A FLOW STREAM
    4.
    发明申请
    METHOD AND APPARATUS FOR RAPIDLY COUNTING AND IDENTIFYING BIOLOGICAL PARTICLES IN A FLOW STREAM 失效
    方法和设备，用于快速计算和识别流动流中的生物颗粒

    公开(公告)号：US20090142765A1

    公开(公告)日：2009-06-04

    申请号：US12262431

    申请日：2008-10-31

    申请人： Giacomo Vacca ,  Richard G. Kendall ,  Norman R. Goldblatt ,  Michael W. Yee ,  Mahesh R. Junnarkar

    发明人： Giacomo Vacca ,  Richard G. Kendall ,  Norman R. Goldblatt ,  Michael W. Yee ,  Mahesh R. Junnarkar

    IPC分类号： G01N21/75 ,  C12Q1/68

    CPC分类号： G01N15/1434 ,  G01N1/38 ,  G01N15/1425 ,  G01N15/1459 ,  G01N2015/0065 ,  G01N2015/1402 ,  G01N2015/1447 ,  G01N2015/1486

    摘要： A method for increasing the throughput, or the precision, or both the precision and the throughput, of a flow cytometer, or of a hematology analyzer employing a flow cytometer, and for further reducing the complexity of such a cytometer or analyzer, by utilizing the technique of laser rastering in combination with a lysis-free single-dilution method. Laser rastering involves sweeping a laser beam across a flowing sample stream in a hematology analyzer. A lysis-free single-dilution method involves performing all the flow cytometer measurements on a sample using a single aliquot, a single lysis-free reagent solution, a single dilution, and a single pass of said dilution through the measurement apparatus. An apparatus suitable for carrying out the method of this invention comprises an optical module comprising a source of light, a scanning device, a lens or system of lenses, a flowcell, detectors, and filters; and an electronic module comprising preamplifiers, analog signal conditioning elements, analog-to-digital converters, field-programmable gate arrays, digital signal processing elements, and data storage elements.

    摘要翻译： 一种用于增加流式细胞仪或使用流式细胞仪的血液分析仪的吞吐量或精度或精度或者吞吐量的方法，并且为了进一步降低这种细胞仪或分析仪的复杂性，通过利用 激光扫描技术与无裂解单稀释法结合使用。 激光扫描涉及通过血液分析仪中的流动样品流扫描激光束。 无裂解的单次稀释法包括使用单次等分试样，单次无裂解试剂溶液，单一稀释液和通过测量装置的所述稀释液单次进行样品上的所有流式细胞仪测量。 适用于实施本发明方法的装置包括一个包括光源的光学模块，一个扫描装置，一个透镜或透镜系统，一个流通池，检测器和过滤器; 以及包括前置放大器，模拟信号调节元件，模拟 - 数字转换器，现场可编程门阵列，数字信号处理元件和数据存储元件的电子模块。

    Performance improvement for hematology analysis
    5.
    发明授权
    Performance improvement for hematology analysis 有权
    血液分析的性能改善

    公开(公告)号：US06916662B2

    公开(公告)日：2005-07-12

    申请号：US10355439

    申请日：2003-01-31

    申请人： Richard G. Kendall ,  Thomas V. Schisano

    发明人： Richard G. Kendall ,  Thomas V. Schisano

    IPC分类号： G01N33/72 ,  G01N33/80 ,  G01N33/86

    CPC分类号： G01N33/721 ,  G01N33/80

    摘要： A method for determining the value of MCV of a fresh sample of blood when the value of MCV for that sample of blood is known, but the period of time that the sample of blood has been stored is not known. The method of this invention allows an automated hematology analyzer to provide a more reliable indication of the initial value of MCV of a sample of blood, i.e., the value of MCV that would have been expected for the sample of blood when the sample was fresh. Furthermore, the method of this invention uses data that is readily available as part of the blood count data.

    摘要翻译： 当已知血液样本的MCV值，但已经存储血液样本的时间段时，确定新鲜血液样本的MCV值的方法是未知的。 本发明的方法允许自动血液分析仪提供血液样品的MCV的初始值的更可靠的指示，即当样品新鲜时对血液样品预期的MCV的值。 此外，本发明的方法使用作为血液计数数据的一部分容易获得的数据。