公开(公告)号：US08623893B2

公开(公告)日：2014-01-07

申请号：US13477778

申请日：2012-05-22

申请人： Gilbert Lassalle ,  Valérie Martin ,  Gary McCort ,  Cécile Volle-Challier

发明人： Gilbert Lassalle ,  Valérie Martin ,  Gary McCort ,  Cécile Volle-Challier

IPC分类号： A61K31/04 ,  C07D215/38

CPC分类号： C07D471/04

摘要： The present invention relates to derivatives of pyridino-pyridinones, and to their preparation and use thereof, having activity as inhibitors of kinase activity of receptors for PDGF (platelet derived growth factors) ligands and optionally of receptors for the FLT3 (fms-like tyrosine kinase receptor) ligand receptors, said derivatives comprising compounds of formula (I): wherein the various substituent groups are more specifically defined herein. The compounds are suitable as therapeutics for the treatment of various proliferative diseases.

摘要翻译： 本发明涉及吡啶并吡啶酮的衍生物及其制备和用途，其具有作为PDGF（血小板衍生生长因子）配体的受体的激酶活性抑制剂和FLT3（fms样酪氨酸激酶 受体）配体受体，所述衍生物包含式（I）化合物：其中各种取代基在本文中更具体地定义。 该化合物适用于治疗各种增殖性疾病。