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    Pyridino-pyridinone derivatives, preparation and therapeutic use thereof
    1.
    发明授权
    Pyridino-pyridinone derivatives, preparation and therapeutic use thereof 有权
    吡啶并吡啶酮衍生物，其制备和治疗用途

    公开(公告)号：US08623893B2

    公开(公告)日：2014-01-07

    申请号：US13477778

    申请日：2012-05-22

    申请人： Gilbert Lassalle ,  Valérie Martin ,  Gary McCort ,  Cécile Volle-Challier

    发明人： Gilbert Lassalle ,  Valérie Martin ,  Gary McCort ,  Cécile Volle-Challier

    IPC分类号： A61K31/04 ,  C07D215/38

    CPC分类号： C07D471/04

    摘要： The present invention relates to derivatives of pyridino-pyridinones, and to their preparation and use thereof, having activity as inhibitors of kinase activity of receptors for PDGF (platelet derived growth factors) ligands and optionally of receptors for the FLT3 (fms-like tyrosine kinase receptor) ligand receptors, said derivatives comprising compounds of formula (I): wherein the various substituent groups are more specifically defined herein. The compounds are suitable as therapeutics for the treatment of various proliferative diseases.

    摘要翻译： 本发明涉及吡啶并吡啶酮的衍生物及其制备和用途，其具有作为PDGF（血小板衍生生长因子）配体的受体的激酶活性抑制剂和FLT3（fms样酪氨酸激酶 受体）配体受体，所述衍生物包含式（I）化合物：其中各种取代基在本文中更具体地定义。 该化合物适用于治疗各种增殖性疾病。

    Pyridone derivatives, their preparation and their use as synthesis intermediates
    3.
    发明授权
    Pyridone derivatives, their preparation and their use as synthesis intermediates 失效
    吡啶酮衍生物，其制备及其作为合成中间体的用途

    公开(公告)号：US06252082B1

    公开(公告)日：2001-06-26

    申请号：US09341574

    申请日：1999-07-14

    申请人： Gilbert Lassalle ,  Patrice Bellevergue ,  Jean-Claude Bourbier ,  Daniel Galtier ,  Valérie Martin

    发明人： Gilbert Lassalle ,  Patrice Bellevergue ,  Jean-Claude Bourbier ,  Daniel Galtier ,  Valérie Martin

    IPC分类号： C07D21186

    CPC分类号： C07D213/64 ,  C07D213/69 ,  C07D213/70 ,  C07D213/71 ,  C07D213/73 ,  C07D213/75 ,  C07D213/76 ,  C07D409/06

    摘要： The invention concerns compounds of formula (I) in which: R is —NO2 or —NHR3, R3 being hydrogen, —COR4 (R4 selected among (C1-C4) alkyl, aryl and aryl (C1-C4) alkyl, —COOR5 (R5 selected among (C1-C4) alkyl and aryl (C1-C4) alkyl), —CONHR6 or SO2R6 (R6 selected among (C1-C5) alkyl, aryl and aryl(C1-C4) alkyl), —SO2NR7R8 (R7 and R8 independently of each other represent hydrogen or (C1-C4) alkyl or form with the nitrogen atom a morpholine group), aryl (C1-C4) alkyl, R1 is a (C1-C4) alkyl group linear or branched, cyclo (C3-C8) alkyl, aryl optionally substituted, aryl (C1-C4) alkyl optionally substituted, heteroaryl, R2 is a hydrogen atom, a (C1-C4) alkyl or arylmethyl group, X is an oxygen or sulphur atom, a —CH2—, —SO2 or —NR1— group and Y is a hydrogen atom or (C1-C6) alkyl. The invention is applicable to synthesis intermediates.

    摘要翻译： 本发明涉及式（I）化合物，其中R为-NO 2或-NHR 3，R 3为氢，-COR 4（R 4选自（C 1 -C 4）烷基，芳基和芳基（C 1 -C 4）烷基，-COOR 5（ （C1-C4）烷基和（C1-C4）烷基），-CONHR6或SO2R6（R6选自（C1-C5）烷基，芳基和芳基（C1-C4）烷基），-SO2NR7R8（R7和 相互独立地表示氢或（C1-C4）烷基或与氮原子形成吗啉基），芳基（C1-C4）烷基，R1是直链或支链的（C1-C4）烷基，环（C3 任选取代的芳基（C 1 -C 4）烷基，杂芳基，R 2是氢原子，（C 1 -C 4）烷基或芳基甲基，X是氧或硫原子，-CH 2 - ，-SO2或-NR1-基，Y为氢原子或（C1-C6）烷基，本发明适用于合成中间体。