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公开(公告)号:US20210179570A1
公开(公告)日:2021-06-17
申请号:US17100107
申请日:2020-11-20
发明人: Katrien Brak , Kae M. Bullock , Greg Cizio , Kathy Dao , Darryl D. Dixon , Joshua R. Dunetz , Luke D. Humphreys , Valerie Huynh , Michael A. Ischay , Trevor C. Johnson , Jeffrey E. Merit , Christopher S. Regens , Eric A. Standley , Dietrich P. Steinhuebel , Justin Y. Su , Tao Wu , Marshall D. Young
IPC分类号: C07D267/16 , C07C311/13 , C07D317/30 , C07D319/06 , C07D513/04 , C07D413/12
摘要: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.
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公开(公告)号:US20200369647A1
公开(公告)日:2020-11-26
申请号:US16869653
申请日:2020-05-08
发明人: Kevin McCormack Allan , Amanda Lynn Vandehey , Gediminas Brizgys , Sachin Dhar , Ian James Doxsee , Alex Goldberg , Lars V. Heumann , Zilin Huang , Nathaniel Thomas Kadunce , Shahrokh Kazerani , Willard Lew , Vinh Xuan Ngo , Brian Michael O`Keefe , Trevor James Rainey , Benjamin James Roberts , Bing Shi , Dietrich P. Steinhuebel , Winston C. Tse , Anna Michelle Wagner , Xianghong Wang , Scott Alan Wolckenhauer , Chloe Yuyi Wong , Jennifer R. Zhang
IPC分类号: C07D401/14 , C07D401/12 , C07D495/10 , C07D339/06 , C07C59/50 , C07D231/56 , C07C45/67 , C07D213/61 , C07D231/54
摘要: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.
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公开(公告)号:US20220009904A1
公开(公告)日:2022-01-13
申请号:US17349288
申请日:2021-06-16
发明人: Kevin McCormack Allan , Amanda Lynn Vandehey , Gediminas Brizgys , Sachin Dhar , Ian James Doxsee , Alex Goldberg , Lars V. Heumann , Zilin Huang , Nathaniel Thomas Kadunce , Shahrokh Kazerani , Willard Lew , Vinh Xuan Ngo , Brian Michael O'Keefe , Trevor James Rainey , Benjamin James Roberts , Bing Shi , Dietrich P. Steinhuebel , Winston C. Tse , Anna Michelle Wagner , Xianghong Wang , Scott Alan Wolckenhauer , Chloe Yuyi Wong , Jennifer R. Zhang
IPC分类号: C07D401/14 , C07D401/12 , C07D495/10 , C07D339/06 , C07C59/50 , C07D231/56 , C07C45/67 , C07D213/61 , C07D231/54
摘要: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I. or a co-crystal, solvate, salt or combination thereof.
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公开(公告)号:US20230013713A1
公开(公告)日:2023-01-19
申请号:US17701404
申请日:2022-03-22
发明人: Katrien Brak , Kae M. Bullock , Greg Cizio , Kathy Dao , Darryl D. Dixon , Joshua R. Dunetz , Luke D. Humphreys , Valerie Huynh , Michael A. Ischay , Trevor C. Johnson , Jeffrey E. Merit , Christopher S. Regens , Eric A. Standley , Dietrich P. Steinhuebel , Justin Y. Su , Tao Wu , Marshall D. Young
IPC分类号: C07D267/16 , C07C311/13 , C07D317/30 , C07D319/06 , C07D413/12 , C07D513/04
摘要: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.
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公开(公告)号:US20220177409A1
公开(公告)日:2022-06-09
申请号:US17528532
申请日:2021-11-17
发明人: Darryl D. Dixon , Michael A. Ischay , Trevor C. Johnson , Jeffrey E. Merit , Christopher S. Regens , Eric A. Standley , Dietrich P. Steinhuebel
IPC分类号: C07C205/06 , C07C211/45 , C07D267/12 , C07D317/12 , C07D513/04
摘要: The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.
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公开(公告)号:US11325891B2
公开(公告)日:2022-05-10
申请号:US17100107
申请日:2020-11-20
发明人: Katrien Brak , Kae M. Bullock , Greg Cizio , Kathy Dao , Darryl D. Dixon , Joshua R. Dunetz , Luke D. Humphreys , Valerie Huynh , Michael A. Ischay , Trevor C. Johnson , Jeffrey E. Merit , Christopher S. Regens , Eric A. Standley , Dietrich P. Steinhuebel , Justin Y. Su , Tao Wu , Marshall D. Young
IPC分类号: C07D267/16 , C07D317/30 , C07D319/06 , C07D413/12 , C07D513/04 , C07C311/13
摘要: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.
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公开(公告)号:US20190300505A1
公开(公告)日:2019-10-03
申请号:US16277552
申请日:2019-02-15
发明人: Kevin McCormack Allan , Amanda Lynn Batten , Gediminas Brizgys , Sachin Dhar , Ian James Doxsee , Alex Goldberg , Lars V. Heumann , Zilin Huang , Nathaniel Thomas Kadunce , Shahrokh Kazerani , Willard Lew , Vinh Xuan Ngo , Brian Michael O'Keefe , Trevor James Rainey , Benjamin James Roberts , Bing Shi , Dietrich P. Steinhuebel , Winston C. Tse , Anna Michelle Wagner , Xianghong Wang , Scott Alan Wolckenhauer , Chloe Yuyi Wong , Jennifer R. Zhang
IPC分类号: C07D401/14
摘要: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.
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