公开(公告)号：US20200255418A1

公开(公告)日：2020-08-13

申请号：US16741101

申请日：2020-01-13

申请人： Gilead Sciences, Inc.

发明人： Peter A. Blomgren ,  Kevin S. Currie ,  Morin Mae Frick ,  Elizabeth M. Horstman ,  Joshua A. Kaplan ,  Jeffrey E. Kropf ,  William J. Watkins

IPC分类号： C07D413/14

摘要： The present disclosure relates generally to compounds that bind to FXR and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

公开(公告)号：US11225473B2

公开(公告)日：2022-01-18

申请号：US16741101

申请日：2020-01-13

申请人： Gilead Sciences, Inc.

发明人： Peter A. Blomgren ,  Kevin S. Currie ,  Morin Mae Frick ,  Elizabeth M. Horstman ,  Joshua A. Kaplan ,  Jeffrey E. Kropf ,  William J. Watkins

IPC分类号： C07D413/14 ,  A61K31/4439 ,  A61P1/16 ,  A61K31/519 ,  A61K31/53 ,  A61K31/397

摘要： The present disclosure relates generally to compounds that bind to FXR and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

公开(公告)号：US20220204491A1

公开(公告)日：2022-06-30

申请号：US17534951

申请日：2021-11-24

申请人： Gilead Sciences, Inc.

发明人： Peter A. Blomgren ,  Kevin S. Currie ,  Morin Mae Frick ,  Elizabeth M. Horstman ,  Joshua A. Kaplan ,  Jeffrey E. Kropf ,  William J. Watkins

IPC分类号： C07D413/14 ,  A61P1/16

摘要： The present disclosure relates generally to compounds that bind to FXR and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.