公开(公告)号：US20220257619A1

公开(公告)日：2022-08-18

申请号：US17627000

申请日：2020-07-17

申请人： Gilead Sciences, Inc. ,  Durect Corporation

发明人： Susan Autio ,  Keith Edward Branham ,  James A. Filice ,  John W. Gibson ,  John J. Leonard ,  James Matriano ,  Whitney Moro ,  Michael Sekar ,  Chelsea Alexandra Snyder ,  Robert G. Strickley ,  Raju Subramanian ,  Felix Theeuwes ,  Monica Tijerina ,  Jeremy C. Wright ,  Su Il Yum ,  Faye Xu

IPC分类号： A61K31/675 ,  A61K47/26 ,  A61K47/34 ,  A61K47/22 ,  A61P31/18

摘要： The present disclosure provides long-acting formulations of tenofovir alafenamide, methods of making the same and methods of using the same.

公开(公告)号：US20230165964A1

公开(公告)日：2023-06-01

申请号：US17983330

申请日：2022-11-08

申请人： DURECT CORPORATION

发明人： Michael Sekar ,  Felix Theeuwes ,  Keith E Branham ,  John W Gibson ,  James Matriano ,  Whitney Moro ,  John Tipton ,  William Van Osdol ,  Su Il Yum

IPC分类号： A61K47/54 ,  A61K9/16 ,  A61K9/19 ,  A61K9/00 ,  A61K47/59 ,  A61K38/26 ,  A61K31/352 ,  A61K31/706 ,  A61K31/785 ,  A61K38/27 ,  A61K38/28 ,  A61K38/31 ,  A61K39/395

CPC分类号： A61K47/54 ,  A61K9/1647 ,  A61K9/19 ,  A61K9/0019 ,  A61K47/593 ,  A61K38/26 ,  A61K31/352 ,  A61K31/706 ,  A61K31/785 ,  A61K38/27 ,  A61K38/28 ,  A61K38/31 ,  A61K39/39516

摘要： The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.

公开(公告)号：US20160303242A1

公开(公告)日：2016-10-20

申请号：US15102519

申请日：2014-12-08

申请人： DURECT CORPORATION

发明人： Michael Sekar ,  Felix Theeuwes ,  Keith E Branham ,  John W Gibson ,  James Matriano ,  Whitney Moro ,  John Tipton ,  William Van Osdol ,  Su Il Yum

IPC分类号： A61K47/48 ,  A61K39/395 ,  A61K31/785 ,  A61K38/28 ,  A61K31/352 ,  A61K9/19 ,  A61K31/706 ,  A61K9/00 ,  A61K38/31 ,  A61K38/27 ,  A61K38/26

CPC分类号： A61K47/54 ,  A61K9/0019 ,  A61K9/1647 ,  A61K9/19 ,  A61K31/352 ,  A61K31/706 ,  A61K31/785 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K38/31 ,  A61K39/39516 ,  A61K47/593

摘要： The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.

摘要翻译： 本公开通常提供了包含药物活性剂和官能化聚合物的复合物，其中所述官能化聚合物包括重复单元，所述重复单元包括具有至少一个可离子化侧基和/或可离子化端基的可离子化重复单元， 至少一个与药物活性剂形成非共价键的可离子化基团。 还可以提供可用于形成这种络合物的聚合物以及制备和使用络合物和相关组合物的方法。

公开(公告)号：US11529420B2

公开(公告)日：2022-12-20

申请号：US16935110

申请日：2020-07-21

申请人： Durect Corporation

发明人： Michael Sekar ,  Felix Theeuwes ,  Keith Edward Branham ,  John W Gibson ,  James Matriano ,  Whitney Moro ,  John Tipton ,  William Van Osdol ,  Su Il Yum

IPC分类号： A61K31/352 ,  A61K31/706 ,  A61K31/785 ,  A61K38/26 ,  A61K38/27 ,  A61K47/54 ,  A61K9/16 ,  A61K9/19 ,  A61K9/00 ,  A61K47/59 ,  A61K38/28 ,  A61K38/31 ,  A61K39/395

摘要： The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.

公开(公告)号：US20210038731A1

公开(公告)日：2021-02-11

申请号：US16935110

申请日：2020-07-21

申请人： Durect Corporation

发明人： Michael Sekar ,  Felix Theeuwes ,  Keith Edward Branham ,  John W. Gibson ,  James Matriano ,  Whitney Moro ,  John Tipton ,  William Van Osdol ,  Su Il Yum

IPC分类号： A61K47/54 ,  A61K9/16 ,  A61K9/19 ,  A61K9/00 ,  A61K47/59 ,  A61K38/26 ,  A61K31/352 ,  A61K31/706 ,  A61K31/785 ,  A61K38/27 ,  A61K38/28 ,  A61K38/31 ,  A61K39/395

摘要： The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.

公开(公告)号：US10758623B2

公开(公告)日：2020-09-01

申请号：US15887916

申请日：2018-02-02

申请人： Durect Corporation

发明人： Michael Sekar ,  Felix Theeuwes ,  Keith E Branham ,  John Gibson ,  James Matriano ,  Whitney Moro ,  John Tipton ,  William Van Osdol ,  Su Il Yum

IPC分类号： A61K31/352 ,  A61K31/706 ,  A61K31/785 ,  A61K38/26 ,  A61K38/27 ,  A61K47/54 ,  A61K9/16 ,  A61K9/19 ,  A61K9/00 ,  A61K47/59 ,  A61K38/28 ,  A61K38/31 ,  A61K39/395

摘要： The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.

公开(公告)号：US20180256727A1

公开(公告)日：2018-09-13

申请号：US15887916

申请日：2018-02-02

申请人： Durect Corporation

发明人： Michael Sekar ,  Felix Theeuwes ,  Keith E Branham ,  John Gibson ,  James Matriano ,  Whitney Moro ,  John Tipton ,  William Van Osdol ,  Su Il Yum

IPC分类号： A61K47/54 ,  A61K39/395 ,  A61K38/31 ,  A61K38/28 ,  A61K38/27 ,  A61K38/26 ,  A61K47/59 ,  A61K31/706 ,  A61K31/352 ,  A61K9/19 ,  A61K9/16 ,  A61K9/00 ,  A61K31/785

摘要： The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.