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公开(公告)号：US11701215B2
公开(公告)日：2023-07-18
申请号：US16266687
申请日：2019-02-04
申请人： Giner, Inc.
发明人： Linda Tempelman , Simon Stone , Klearchos Papas
CPC分类号： A61F2/022 , A61K48/0075 , A61M2005/006 , A61M2005/14204 , A61M2202/0208 , A61M2205/7536
摘要： System for gas treatment of cellular implants. The system enhances the viability and function of cellular implants, particularly those with high cellular density, for use in human or veterinary medicine. The system utilizes a miniaturized electrochemical gas generator subsystem that continuously supplies oxygen and/or hydrogen to cells within an implantable and immunoisolated cell containment subsystem to facilitate cell viability and function at high cellular density while minimizing overall implant size. The cell containment subsystem is equipped with features to allow gas delivery through porous tubing or gas-only permeable internal gas compartments within the implantable cell containment subsystem. Furthermore, the gas generator subsystem includes components that allow access to water for electrolysis while implanted, thereby promoting long-term implantability of the gas generator subsystem. An application of the system is a pancreatic islet (or pancreatic islet analogue) implant for treatment of Type 1 diabetes (T1D) that would be considered a bio-artificial pancreas.
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公开(公告)号：US10231817B2
公开(公告)日：2019-03-19
申请号：US14495644
申请日：2014-09-24
申请人： Giner, Inc.
发明人： Linda Tempelman , Simon Stone , Klearchos Papas
摘要： System for gas treatment of cellular implants. The system enhances the viability and function of cellular implants, particularly those with high cellular density, for use in human or veterinary medicine. The system utilizes a miniaturized electrochemical gas generator subsystem that continuously supplies oxygen and/or hydrogen to cells within an implantable and immunoisolated cell containment subsystem to facilitate cell viability and function at high cellular density while minimizing overall implant size. The cell containment subsystem is equipped with features to allow gas delivery through porous tubing or gas-only permeable internal gas compartments within the implantable cell containment subsystem. Furthermore, the gas generator subsystem includes components that allow access to water for electrolysis while implanted, thereby promoting long-term implantability of the gas generator subsystem. An application of the system is a pancreatic islet (or pancreatic islet analog) implant for treatment of Type 1 diabetes (T1D) that would be considered a bio-artificial pancreas.
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公开(公告)号：US12070383B2
公开(公告)日：2024-08-27
申请号：US18222633
申请日：2023-07-17
申请人： Giner, Inc.
发明人： Linda Tempelman , Simon Stone , Klearchos Papas
CPC分类号： A61F2/022 , A61K48/0075 , A61M2005/006 , A61M2005/14204 , A61M2202/0208 , A61M2205/7536
摘要： System for gas treatment of cellular implants. The system enhances the viability and function of cellular implants, particularly those with high cellular density, for use in human or veterinary medicine. The system utilizes a miniaturized electrochemical gas generator subsystem that continuously supplies oxygen and/or hydrogen to cells within an implantable and immunoisolated cell containment subsystem to facilitate cell viability and function at high cellular density while minimizing overall implant size. The cell containment subsystem is equipped with features to allow gas delivery through porous tubing or gas-only permeable internal gas compartments within the implantable cell containment subsystem. Furthermore, the gas generator subsystem includes components that allow access to water for electrolysis while implanted, thereby promoting long-term implantability of the gas generator subsystem. An application of the system is a pancreatic islet (or pancreatic islet analogue) implant for treatment of Type 1 diabetes (T1D) that would be considered a bio-artificial pancreas.
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公开(公告)号：US20240189088A1
公开(公告)日：2024-06-13
申请号：US18222633
申请日：2023-07-17
申请人： Giner, Inc.
发明人： Linda Tempelman , Simon Stone , Klearchos Papas
CPC分类号： A61F2/022 , A61K48/0075 , A61M2005/006 , A61M2005/14204 , A61M2202/0208 , A61M2205/7536
摘要： System for gas treatment of cellular implants. The system enhances the viability and function of cellular implants, particularly those with high cellular density, for use in human or veterinary medicine. The system utilizes a miniaturized electrochemical gas generator subsystem that continuously supplies oxygen and/or hydrogen to cells within an implantable and immunoisolated cell containment subsystem to facilitate cell viability and function at high cellular density while minimizing overall implant size. The cell containment subsystem is equipped with features to allow gas delivery through porous tubing or gas-only permeable internal gas compartments within the implantable cell containment subsystem. Furthermore, the gas generator subsystem includes components that allow access to water for electrolysis while implanted, thereby promoting long-term implantability of the gas generator subsystem. An application of the system is a pancreatic islet (or pancreatic islet analogue) implant for treatment of Type 1 diabetes (T1D) that would be considered a bio-artificial pancreas.
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公开(公告)号：US20150112247A1
公开(公告)日：2015-04-23
申请号：US14495644
申请日：2014-09-24
申请人： Giner, Inc.
发明人： Linda Tempelman , Simon Stone , Klearchos Papas
CPC分类号： A61F2/022 , A61K48/0075 , A61M2005/006 , A61M2005/14204 , A61M2202/0208 , A61M2205/7536
摘要： System for gas treatment of cellular implants. The system enhances the viability and function of cellular implants, particularly those with high cellular density, for use in human or veterinary medicine. The system utilizes a miniaturized electrochemical gas generator subsystem that continuously supplies oxygen and/or hydrogen to cells within an implantable and immunoisolated cell containment subsystem to facilitate cell viability and function at high cellular density while minimizing overall implant size. The cell containment subsystem is equipped with features to allow gas delivery through porous tubing or gas-only permeable internal gas compartments within the implantable cell containment subsystem. Furthermore, the gas generator subsystem includes components that allow access to water for electrolysis while implanted, thereby promoting long-term implantability of the gas generator subsystem. An application of the system is a pancreatic islet (or pancreatic islet analogue) implant for treatment of Type 1 diabetes (T1D) that would be considered a bio-artificial pancreas.
摘要翻译： 细胞植入物气体处理系统。 该系统增强了用于人类或兽医学中的细胞植入物，特别是具有高细胞密度的细胞植入物的活力和功能。 该系统利用小型化的电化学气体发生器子系统，其连续向可植入和免疫鉴别的细胞容纳子系统内的细胞提供氧气和/或氢气，以促进细胞活力并在高细胞密度下起作用，同时最小化整体植入物尺寸。 细胞容纳子系统配备有允许气体通过可植入细胞容纳子系统内的多孔管或仅气体可渗透内部气体隔室的特征。 此外，气体发生器子系统包括允许在植入时进入电解电解的部件，从而促进气体发生器子系统的长期可植入性。 该系统的应用是用于治疗被认为是生物人造胰腺的1型糖尿病（T1D）的胰岛（或胰岛胰岛素类似物）植入物。
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