公开(公告)号：US4968832A

公开(公告)日：1990-11-06

申请号：US212472

申请日：1988-06-28

申请人： Giorgio Bianchi ,  Dante Nardi ,  Amedeo Leonardo ,  Gabriel Kraziani

发明人： Giorgio Bianchi ,  Dante Nardi ,  Amedeo Leonardo ,  Gabriel Kraziani

IPC分类号： A61K31/41 ,  A61K31/435 ,  A61K31/44 ,  A61K31/455 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07C67/00 ,  C07C201/00 ,  C07C205/56 ,  C07D211/90 ,  C07D413/04 ,  C07D413/14

CPC分类号： C07D413/04 ,  C07C205/56 ,  C07D211/90

摘要： Novel antihypertensive and coronary dilating asymmetric diesters of 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid (or the stereoisomers or pharmaceutically acceptable acid addition salts thereof) have the general formula (I): ##STR1## wherein Ph is phenyl, Ar is 2-nitrophenyl, 3-nitrophenyl, 2,3-dichlorophenyl or benzofurazan-4-yl, A is a straight or branched chain alkylene radical having from 2 to 6 carbon atoms, R is a straight or branched chain alkyl radical having from 1 to 6 carbon atoms, optionally mono-substituted by an alkoxy substituent having from 1 to 6 carbon atoms, R.sub.1 is hydrogen, hydroxy or an alkyl radical having from 1 to 4 carbon atoms, and R.sub.2 is hydrogen or methyl. The subject diesters are facilely prepared from the aldehydes ArCHO and esters of acetoacetic and 3-aminocrotonic acids.