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公开(公告)号：US20110192493A1
公开(公告)日：2011-08-11
申请号：US13087012
申请日：2011-04-14
申请人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Enrico Braglia , Riccardo Braglia , Andrew Miksztal , Thomas Malefyt , Kathleen M. Lee
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Enrico Braglia , Riccardo Braglia , Andrew Miksztal , Thomas Malefyt , Kathleen M. Lee
IPC分类号： B65B3/04 , A61K31/473 , A61P1/08 , A61P35/00
CPC分类号： A61K9/08 , A61J3/00 , A61K9/0019 , A61K9/0053 , A61K31/4178 , A61K31/473 , A61K31/4747 , A61K47/02 , A61K47/12 , A61K47/16 , A61K47/183 , A61K47/26 , B65B3/04 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
摘要翻译： 本发明涉及帕洛诺司琼用于减轻化学疗法和放射治疗诱发呕吐与帕洛诺司琼的货架稳定液体制剂。 制剂特别可用于制备静脉内和口服液体药物。
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公开(公告)号：US20060167073A1
公开(公告)日：2006-07-27
申请号：US11388270
申请日：2006-03-24
IPC分类号： A61K31/4178
CPC分类号： A61K9/08 , A61J3/00 , A61K9/0019 , A61K9/0053 , A61K31/4178 , A61K31/473 , A61K31/4747 , A61K47/02 , A61K47/12 , A61K47/16 , A61K47/183 , A61K47/26 , B65B3/04 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US20060069114A1
公开(公告)日：2006-03-30
申请号：US11186311
申请日：2005-07-21
IPC分类号： A61K31/4745
CPC分类号： A61K9/08 , A61J3/00 , A61K9/0019 , A61K9/0053 , A61K31/4178 , A61K31/473 , A61K31/4747 , A61K47/02 , A61K47/12 , A61K47/16 , A61K47/183 , A61K47/26 , B65B3/04 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US07960424B2
公开(公告)日：2011-06-14
申请号：US11388270
申请日：2006-03-24
申请人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Enrico Braglia , Riccardo Braglia , Andrew Miksztal , Thomas Malefyt , Kathleen M. Lee
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Enrico Braglia , Riccardo Braglia , Andrew Miksztal , Thomas Malefyt , Kathleen M. Lee
IPC分类号： A01N43/52
CPC分类号： A61K9/08 , A61J3/00 , A61K9/0019 , A61K9/0053 , A61K31/4178 , A61K31/473 , A61K31/4747 , A61K47/02 , A61K47/12 , A61K47/16 , A61K47/183 , A61K47/26 , B65B3/04 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
摘要翻译： 本发明涉及帕洛诺司琼用于减轻化学疗法和放射治疗诱发呕吐与帕洛诺司琼的货架稳定液体制剂。 制剂特别可用于制备静脉内和口服液体药物。
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公开(公告)号：US07947725B2
公开(公告)日：2011-05-24
申请号：US11388268
申请日：2006-03-24
申请人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Enrico Braglia , Riccardo Braglia , Andrew Miksztal , Thomas Malefyt , Kathleen M. Lee
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Enrico Braglia , Riccardo Braglia , Andrew Miksztal , Thomas Malefyt , Kathleen M. Lee
IPC分类号： A01N43/52
CPC分类号： A61K9/08 , A61J3/00 , A61K9/0019 , A61K9/0053 , A61K31/4178 , A61K31/473 , A61K31/4747 , A61K47/02 , A61K47/12 , A61K47/16 , A61K47/183 , A61K47/26 , B65B3/04 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US07947724B2
公开(公告)日：2011-05-24
申请号：US11186311
申请日：2005-07-21
申请人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Enrico Braglia , Riccardo Braglia , Andrew Miksztal , Thomas Malefyt , Kathleen M. Lee
发明人： Giorgio Calderari , Daniele Bonadeo , Roberta Cannella , Enrico Braglia , Riccardo Braglia , Andrew Miksztal , Thomas Malefyt , Kathleen M. Lee
IPC分类号： A01N43/52
CPC分类号： A61K9/08 , A61J3/00 , A61K9/0019 , A61K9/0053 , A61K31/4178 , A61K31/473 , A61K31/4747 , A61K47/02 , A61K47/12 , A61K47/16 , A61K47/183 , A61K47/26 , B65B3/04 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US20060167072A1
公开(公告)日：2006-07-27
申请号：US11388269
申请日：2006-03-24
IPC分类号： A61K31/4178
CPC分类号： A61K31/4178
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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公开(公告)号：US20060167071A1
公开(公告)日：2006-07-27
申请号：US11388268
申请日：2006-03-24
IPC分类号： A61K31/4178
CPC分类号： A61K9/08 , A61J3/00 , A61K9/0019 , A61K9/0053 , A61K31/4178 , A61K31/473 , A61K31/4747 , A61K47/02 , A61K47/12 , A61K47/16 , A61K47/183 , A61K47/26 , B65B3/04 , B65B55/02
摘要： The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.
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9.发明申请Dosage Forms of Palonosetron Hydrochloride Having Improved Stability and Bioavailability 审中-公开盐酸帕洛诺司琼的剂型改善了稳定性和生物利用度公开(公告)号：US20080152704A1
公开(公告)日：2008-06-26
申请号：US11877722
申请日：2007-10-24
IPC分类号： A61K9/48 , A61K31/439
CPC分类号： A61K31/473 , A61K9/0053 , A61K9/4825 , A61K9/4858
摘要： Provided are solid oral dosage forms of palonosetron hydrochloride, methods of using the dosage forms to treat emesis, and methods of making the dosage forms. The dosage forms have improved stability and bioavailability, and are preferably in the form of liquid filled capsules.
摘要翻译： 提供了盐酸帕洛诺司琼的固体口服剂型，使用剂型治疗呕吐的方法，以及制备剂型的方法。 剂型具有改善的稳定性和生物利用度，并且优选为液体填充胶囊的形式。
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10.发明申请CRYSTALLINE AND AMORPHOUS FORMS OF PALONOSETRON HYDROCHLORIDE 审中-公开PALONOSETRON HYDROCHLORIDE的晶体和非晶形式公开(公告)号：US20100105724A1
公开(公告)日：2010-04-29
申请号：US12513589
申请日：2007-12-04
申请人： Waldo Mossi , Giorgio Calderari , Enrico Braglia , Riccardo Braglia , Wilma Timraz , Tai Wah Chan
发明人： Waldo Mossi , Giorgio Calderari , Enrico Braglia , Riccardo Braglia , Wilma Timraz , Tai Wah Chan
IPC分类号： A61K31/439 , C07D453/02
CPC分类号： C07D453/02 , A61K31/415
摘要： Amorphous and polymorphic of palonosetron hydrochloride are disclosed that can be characterized by X-ray powder diffraction patterns, thermal properties, purity and methods of manufacture. These forms of palonosetron hydrochloride can be produced from solution or by solid state interconversions. The forms can be used in pharmaceutical formulations: particularly preferred uses of these formulations are in prevention and treatment of nausea and emesis arising from chemotherapy or postoperative side effects. The forms can optionally be used as mixtures of the crystalline and/or amorphous forms.
摘要翻译： 公开了盐酸帕洛诺司琼的无定形和多晶型物，其可以通过X射线粉末衍射图，热性质，纯度和制造方法来表征。 这些形式的盐酸帕洛诺司琼可以通过溶液或通过固相互变而产生。 这些形式可以用于药物制剂中：这些制剂的特别优选用途是预防和治疗由化疗或术后副作用引起的恶心和呕吐。 这些形式可以任选地用作结晶和/或无定形形式的混合物。
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