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1.发明授权公开(公告)号：US09138407B2
公开(公告)日：2015-09-22
申请号：US12090899
申请日：2006-10-20
CPC分类号： A61K9/0078 , A61K9/0075 , A61K45/06
摘要： Provided is an inhalatory pharmaceutical composition that comprises a drug, a soluble excipient and a surfactant, wherein the soluble excipient is present in an amount between 10% and less than 100% by weight; and the solid excipient forms a solid matrix in which the drug is dispersed; the weight ratio between the surfactant and drug is between 0.01 and 10; the particle size of at least 50% of the particles of the powder is below 5 μm; the bulk density db of the powder is between 0.1 and 0.3 g/cc; the tapped density dt of the powder is between 0.15 and 0.7 g/cc and the ratio db/dt is between 0.2 and 0.65. Also provided is the method for fabricating the composition.
摘要翻译： 本发明提供一种吸入性药物组合物，其包含药物，可溶性赋形剂和表面活性剂，其中所述可溶性赋形剂的存在量为10重量％至小于100重量％ 固体赋形剂形成药物分散的固体基质; 表面活性剂与药物的重量比为0.01〜10; 粉末颗粒的至少50％的粒径小于5μm; 粉末的体积密度db在0.1至0.3g / cc之间; 粉末的抽头密度dt在0.15和0.7g / cc之间，比率db / dt在0.2和0.65之间。 还提供了用于制造组合物的方法。
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2.发明申请公开(公告)号：US20080226736A1
公开(公告)日：2008-09-18
申请号：US12090899
申请日：2006-10-20
IPC分类号： A61K9/72 , A61K31/137 , A61K31/138 , A61K31/546 , A61M15/00 , A61K31/58
CPC分类号： A61K9/0078 , A61K9/0075 , A61K45/06
摘要： Inhalatory pharmaceutical composition comprising a drug, a soluble excipient and a surfactant, characterized by: said soluble excipient is present in an amount between 10% and less than 100% by weight; —the weight ratio between said surfactant and said drug is between 0.01 and 10; —the particle size of at least 50% of the particles of said powder is below 5 μm; —the bulk density db of said powder is between 0.1 and 0.3 g/cc; —the tapped density dt of said powder is between 0.15 and 0.7 g/cc; —the ratio db/dt is between 0.2 and 0.65.
摘要翻译： 包含药物，可溶性赋形剂和表面活性剂的吸入药物组合物，其特征在于：所述可溶性赋形剂以10重量％至小于100重量％的量存在; 所述表面活性剂与所述药物之间的重量比为0.01至10; - 所述粉末的至少50％的颗粒的粒径小于5μm; - 所述粉末的体积密度d b b为0.1至0.3g / cc; - 所述粉末的敲击密度d t t为0.15-0.7g / cc; - 比率d / b / d 在0.2和0.65之间。
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