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    Inhalatory pharmaceutical compositions in form of dry powders, solutions or suspensions obtained from the same and process for their preparation
    1.
    发明授权
    Inhalatory pharmaceutical compositions in form of dry powders, solutions or suspensions obtained from the same and process for their preparation 有权
    以干粉，溶液或悬浮液形式的吸入药物组合物及其制备方法

    公开(公告)号：US09138407B2

    公开(公告)日：2015-09-22

    申请号：US12090899

    申请日：2006-10-20

    申请人： Giovanni Caponetti ,  Loretta Maggi ,  Laura Zanellotti ,  Cristina Veneziani

    发明人： Giovanni Caponetti ,  Loretta Maggi ,  Laura Zanellotti ,  Cristina Veneziani

    IPC分类号： A61K9/14 ,  A61K9/00 ,  A61K45/06

    CPC分类号： A61K9/0078 ,  A61K9/0075 ,  A61K45/06

    摘要： Provided is an inhalatory pharmaceutical composition that comprises a drug, a soluble excipient and a surfactant, wherein the soluble excipient is present in an amount between 10% and less than 100% by weight; and the solid excipient forms a solid matrix in which the drug is dispersed; the weight ratio between the surfactant and drug is between 0.01 and 10; the particle size of at least 50% of the particles of the powder is below 5 μm; the bulk density db of the powder is between 0.1 and 0.3 g/cc; the tapped density dt of the powder is between 0.15 and 0.7 g/cc and the ratio db/dt is between 0.2 and 0.65. Also provided is the method for fabricating the composition.

    摘要翻译： 本发明提供一种吸入性药物组合物，其包含药物，可溶性赋形剂和表面活性剂，其中所述可溶性赋形剂的存在量为10重量％至小于100重量％ 固体赋形剂形成药物分散的固体基质; 表面活性剂与药物的重量比为0.01〜10; 粉末颗粒的至少50％的粒径小于5μm; 粉末的体积密度db在0.1至0.3g / cc之间; 粉末的抽头密度dt在0.15和0.7g / cc之间，比率db / dt在0.2和0.65之间。 还提供了用于制造组合物的方法。

    Process for the preparation of granular and porous sucralfate dry gel
    6.
    发明授权
    Process for the preparation of granular and porous sucralfate dry gel 有权
    粒状和多孔硫糖铝干凝胶的制备方法

    公开(公告)号：US06706286B1

    公开(公告)日：2004-03-16

    申请号：US09744869

    申请日：2001-01-29

    申请人： Giorgio Zagnoli ,  Paolo Colombo ,  Loretta Maggi ,  Fabrizio Cudazzo

    发明人： Giorgio Zagnoli ,  Paolo Colombo ,  Loretta Maggi ,  Fabrizio Cudazzo

    IPC分类号： A61K914

    CPC分类号： A61K9/145 ,  A61K9/0056 ,  A61K9/209

    摘要： Sucralfate gel in the dry state in porous granular form having a particle-size distribution of between 100 and 1000 &mgr;m, an apparent density of the powder bed of between 0.7 and 0.9 g/ml, a settling index of between 5 and 15%, and a residual humidity of between 5 and 15%, and the corresponding process of preparation, which comprises a treatment with microwaves of a diluted solution of powdered sucralfate gel, with a sucralfate titre of between 20 and 70 wt. %. This solid product may be advantageously used in the preparation of solid pharmaceutical compositions that contain it as single active principle, or else as coating of solid compositions that contain, as active principle, a substance that may cause lesions to the gastric mucosa.

    摘要翻译： 处于干燥状态的蔗糖凝胶以粒径分布为100至1000μm的多孔颗粒形式，粉末床的表观密度为0.7至0.9g / ml，沉降指数为5至15％，和 残余湿度在5至15％之间，以及相应的制备方法，其包括用粉状硫糖铝凝胶的稀释溶液的微波处理，硫糖铝滴定剂为20至70重量％。 ％。 该固体产品可有利地用于制备含有它作为单一活性成分的固体药物组合物，或者作为活性成分含有可能引起胃粘膜损害的物质的固体组合物的包衣。

    Process for the preparation of granular and porous sucralfate dry gel
    7.
    发明授权
    Process for the preparation of granular and porous sucralfate dry gel 有权
    粒状和多孔硫糖铝干凝胶的制备方法

    公开(公告)号：US06773722B2

    公开(公告)日：2004-08-10

    申请号：US10449266

    申请日：2003-05-29

    申请人： Giorgio Zagnoli ,  Paolo Colombo ,  Loretta Maggi ,  Fabrizio Cudazzo

    发明人： Giorgio Zagnoli ,  Paolo Colombo ,  Loretta Maggi ,  Fabrizio Cudazzo

    IPC分类号： A61K928

    CPC分类号： A61K9/145 ,  A61K9/0056 ,  A61K9/209

    摘要： Sucralfate gel in the dry state in porous granular form having a particle-size distribution of between 100 and 1000 &mgr;m, an apparent density of the powder bed of between 0.7 and 0.9 g/ml, a settling index of between 5 and 15%, and a residual humidity of between 5 and 15%, and the corresponding process of preparation, which comprises a treatment with microwaves of a diluted solution of powdered sucralfate gel, with a sucralfate titer of between 20 and 70 wt. %. This solid product may be advantageously used in the preparation of solid pharmaceutical compositions that contain it as single active principle, or else as coating of solid compositions that contain, as active principle, a substance that may cause lesions to the gastric mucosa.

    摘要翻译： 处于干燥状态的蔗糖凝胶以粒径分布为100至1000μm的多孔颗粒形式，粉末床的表观密度为0.7至0.9g / ml，沉降指数为5至15％，和 残余湿度在5至15％之间，以及相应的制备方法，其包括用微粉硫酸铝凝胶的稀释溶液的微波处理，硫糖铝滴定度为20至70重量％。 ％。 该固体产品可有利地用于制备含有它作为单一活性成分的固体药物组合物，或者作为活性成分含有可能引起胃粘膜损害的物质的固体组合物的包衣。