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1.发明申请公开(公告)号：US20070036834A1
公开(公告)日：2007-02-15
申请号：US11522126
申请日：2006-09-15
IPC分类号： A61K36/906 , A61K36/28 , A61K36/752 , A61K36/67 , A61K36/84 , A61K36/00 , A61K9/14
CPC分类号： A61K36/61 , A61K9/0034 , A61K9/006 , A61K9/02 , A61K9/122 , A61K36/16 , A61K36/185 , A61K36/235 , A61K36/24 , A61K36/254 , A61K36/258 , A61K36/28 , A61K36/324 , A61K36/38 , A61K36/48 , A61K36/537 , A61K36/54 , A61K36/67 , A61K36/71 , A61K36/734 , A61K36/752 , A61K36/77 , A61K36/82 , A61K36/84 , A61K36/87 , A61K36/889 , A61K36/8962 , A61K36/906 , A61K36/9066 , A61K36/9068 , B33Y80/00 , A61K2300/00
摘要： A vaginal or buccal delivery of therapeutic agents having a substrate affinity for metabolic cytochrome P-450 enzymes and membrane efflux transporter systems. A method for augmentation of systemic exposure to the therapeutic agents having a substrate affinity for cytochrome P-450 enzymes and membrane efflux transporter systems, by delivering said agents to the systemic circulation through vaginal or buccal mucosa.
摘要翻译： 对代谢细胞色素P-450酶和膜外排运输系统具有底物亲和力的治疗剂的阴道或口腔递送。 通过将所述药物通过阴道或颊粘膜递送至全身循环，增加对细胞色素P-450酶和膜外排转运体系具有底物亲和力的治疗剂的全身暴露的方法。
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2.发明申请Coated vaginal device for delivery of anti-migraine and anti-nausea drugs and a method for treatment of migraine and nausea 有权用于输送抗偏头痛和抗恶心药物的涂层阴道装置和治疗偏头痛和恶心的方法公开(公告)号：US20050249774A1
公开(公告)日：2005-11-10
申请号：US11126863
申请日：2005-05-10
申请人： Giovanni Pauletti , Michelle Wilson , Richard Soderstrom , Kishorkumar Desai , Wolfgang Ritschel
发明人： Giovanni Pauletti , Michelle Wilson , Richard Soderstrom , Kishorkumar Desai , Wolfgang Ritschel
CPC分类号： A61F6/06 , A61F6/08 , A61F13/2051 , A61K9/0034 , A61K9/0036 , A61K9/02 , A61K9/122 , A61K9/7007
摘要： A vaginal device for delivery of an anti-migraine or anti-nausea drug to the uterus and/or to the general circulation through vaginal mucosa. The device is at least partially coated with one or several layers of fluid impermeable material forming a cap, film, foam, foil or strip incorporated with mucoadhesive composition comprising the anti-migraine or anti-nausea drug.
摘要翻译： 用于通过阴道粘膜递送抗偏头痛或抗恶心药物到子宫和/或一般循环的阴道装置。 该装置至少部分地涂覆有形成具有包含抗偏头痛或抗恶心药物的粘膜粘附组合物的帽，膜，泡沫，箔或条的一层或几层流体不可渗透材料。
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3.发明申请公开(公告)号：US20060002966A1
公开(公告)日：2006-01-05
申请号：US11208209
申请日：2005-08-18
申请人： Giovanni Pauletti , James Liu , Leslie Benet , Wolfgang Ritschel
发明人： Giovanni Pauletti , James Liu , Leslie Benet , Wolfgang Ritschel
IPC分类号： A61K38/13 , A61K31/704 , A61K31/4745
CPC分类号： A61K9/0034 , A61K9/0036
摘要： Devices, methods, and compositions for cancer therapy by administration of chemotherapeutic agents and/or inhibitors of membrane efflux systems to the vagina for topical and systemic tumor targets.
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