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公开(公告)号：US06972566B2
公开(公告)日：2005-12-06
申请号：US10764981
申请日：2004-01-26
申请人： Gisela Guthausen , Arne Kasten
发明人： Gisela Guthausen , Arne Kasten
摘要： A description is given of a method for determining the content of a first component of a sample, which first component provides a first NMR signal and has a first self-diffusion coefficient D1, the sample additionally containing at least one further component which provides a further NMR signal and has a larger self-diffusion coefficient D2, in particular for determining the fat content of a hydrous sample, with the aid of a low-resolution nuclear magnetic resonance (NMR) pulse spectrometer, the sample being excited by a radio-frequency (RF) excitation pulse and being exposed to a magnetic gradient field and to a sequence of further refocusing RF pulses for generating spin echo signals, the spin echo signals being detected and their amplitude values being determined, from which a value for the content of the first component of the sample is determined. The magnetic gradient field is not switched off during the sequence of further refocusing RF pulses.
摘要翻译： 给出了用于确定样品的第一组分的含量的方法的描述，该第一组分提供第一NMR信号并具有第一自扩散系数D 1，样品另外含有 至少一个另外的组分，其提供另外的NMR信号并且具有较大的自扩散系数D 2，特别是用于通过低分辨率核磁铁来确定含水样品的脂肪含量 共振（NMR）脉冲光谱仪，样品被射频（RF）激发脉冲激发并暴露于磁梯度场和进一步重新聚焦RF脉冲序列以产生自旋回波信号，检测到自旋回波信号 并且确定它们的振幅值，由此确定样品的第一组分的含量的值。 在进一步重新聚焦RF脉冲的序列期间，磁梯度场不被关闭。
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2.发明授权Analysis system with GPC and NMR spectroscopy coupling, in particular for the analysis of samples having polymers 有权具有GPC和NMR光谱耦合的分析系统，特别是用于分析具有聚合物的样品公开(公告)号：US08624599B2
公开(公告)日：2014-01-07
申请号：US12929748
申请日：2011-02-14
IPC分类号： G01V3/00
CPC分类号： G01R33/307 , G01N30/467 , G01N30/62 , G01N30/78 , G01R33/46
摘要： An analysis system (1) for the analysis of a sample, comprises a gel permeation chromatograph (14) that is coupled with a nuclear magnetic resonance (=NMR) spectrometer. The chromatograph (14) has a gel permeation chromatography (=GPC) separating column system (6a) that is filled with porous particles (21). The NMR spectrometer is configured as a low-field NMR spectrometer (8) with a permanent magnet system (9) for generating a B0 field of the NMR spectrometer. The low-field NMR spectrometer (8) comprises a shim system (10) with which homogeneity of the B0 field of at least 0.5 ppm can be achieved in a right circular cylindrical sample volume (27) having a diameter of at least 5 mm and a length of at least 15 mm. The system permits the quantitative and qualitative chemical analysis of samples containing substances of different molecular size using a less expensive apparatus.
摘要翻译： 用于分析样品的分析系统（1）包括与核磁共振（= NMR）光谱仪耦合的凝胶渗透色谱仪（14）。 色谱仪（14）具有填充有多孔颗粒（21）的凝胶渗透色谱（= GPC）分离柱系统（6a）。 NMR光谱仪被配置为具有用于产生NMR光谱仪的B0场的永磁体系统（9）的低场NMR光谱仪（8）。 低场NMR光谱仪（8）包括垫片系统（10），其直径为至少5mm的右圆形圆柱形样品体积（27）可以实现至少0.5ppm的B0场的均匀性， 长度至少为15毫米。 该系统允许使用较便宜的装置对含有不同分子尺寸的物质的样品进行定量和定性化学分析。
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3.发明申请Analysis system with GPC and NMR spectroscopy coupling, in particular for the analysis of samples having polymers 有权具有GPC和NMR光谱耦合的分析系统，特别是用于分析具有聚合物的样品公开(公告)号：US20110204894A1
公开(公告)日：2011-08-25
申请号：US12929748
申请日：2011-02-14
CPC分类号： G01R33/307 , G01N30/467 , G01N30/62 , G01N30/78 , G01R33/46
摘要： An analysis system (1) for the analysis of a sample, comprises a gel permeation chromatograph (14) that is coupled with a nuclear magnetic resonance(=NMR) spectrometer. The chromatograph (14) has a gel permeation chromatography(=GPC) separating column system (6a) that is filled with porous particles (21). The GPC separating column system (6a) includes at least the one GPC separating column (6), the GPC separating columns (6) of the GPC separating column system (6a) having an overall combined internal volume of at least 45 cm3, preferably at least 100 cm3. The NMR spectrometer is configured as a low-field NMR spectrometer (8) with a permanent magnet system (9) for generating a B0 field of the NMR spectrometer. The low-field NMR spectrometer (8) comprises a shim system (10) with which homogeneity of the B0 field of 0.5 ppm or better, preferably 0.1 ppm or better, can be achieved in a right circular cylindrical sample volume (27) having a diameter of at least 5 mm and a length of at least 15 mm. The low-field NMR spectrometer (8) further comprises a lock function (29) to compensate for a drift of the B0 field. The invention permits the quantitative and qualitative chemical analysis of samples containing substances of different molecular size with less expensive apparatus.
摘要翻译： 用于分析样品的分析系统（1）包括与核磁共振（= NMR）光谱仪耦合的凝胶渗透色谱仪（14）。 色谱仪（14）具有填充有多孔颗粒（21）的凝胶渗透色谱（= GPC）分离柱系统（6a）。 GPC分离塔系统（6a）至少包括一个GPC分离塔（6），GPC分离塔系统（6a）的GPC分离柱（6）的总体内部体积至少为45cm 3，优选地 至少100 cm3。 NMR光谱仪被配置为具有用于产生NMR光谱仪的B0场的永磁体系统（9）的低场NMR光谱仪（8）。 低场NMR光谱仪（8）包括一个垫片系统（10），其中B0场的均匀性在0.5ppm或更好，优选0.1ppm或更好的情况下可以在具有 直径至少为5mm，长度至少为15mm。 低场NMR光谱仪（8）还包括用于补偿B0场漂移的锁定功能（29）。 本发明允许对具有不同分子尺寸的物质的样品进行定量和定性化学分析，其中较便宜的装置。
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4.发明申请公开(公告)号：US20050270026A1
公开(公告)日：2005-12-08
申请号：US11119413
申请日：2005-04-29
摘要： A method is described for determination of the content of at least one component of a sample by means of a nuclear magnetic resonance pulse spectrometer, with the magnetization of the sample being influenced by a sequence of radio-frequency pulses such that the signal amplitudes to be observed can be determined. The magnetization of the sample is initially saturated, and the signal amplitudes which are determined at each time by the longitudinal and transverse relaxation times T1 and T2 and/or T2* and/or T1p, from which a value for the content of the at least one component is determined, are measured at the same time in a cohesive experimental procedure.
摘要翻译： 描述了通过核磁共振脉冲光谱仪确定样品的至少一个组分的含量的方法，其中样品的磁化受到一系列射频脉冲的影响，使得信号幅度为 观察可以确定。 样品的磁化最初饱和，并且每次通过纵向和横向弛豫时间T 1和T 2和/或T 2确定的信号幅度， 在粘性实验过程中同时测量从其中确定至少一种组分的含量的值的第二个和第二个碱基和/或T 1p 。
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