公开(公告)号：US20240287246A1

公开(公告)日：2024-08-29

申请号：US18652912

申请日：2024-05-02

申请人： Zephyros, Inc.

发明人： Michael Czaplicki ,  Kevin Hicks

IPC分类号： C08G59/40 ,  C08G59/14 ,  C08G59/42 ,  C08J9/04 ,  C08J9/06 ,  C08J9/08 ,  C08J9/12 ,  G01R33/46

CPC分类号： C08G59/4071 ,  C08G59/1488 ,  C08G59/4269 ,  C08J9/04 ,  C08J9/06 ,  C08J9/08 ,  C08J9/12 ,  C08J2201/022 ,  C08J2203/02 ,  C08J2363/00 ,  G01R33/46

摘要： The present teachings contemplate a method that includes a step of providing a first amount of esterified reaction product of an acid and an epoxy-based material. The esterified reaction product may be further reacted an epoxy resin to form a polymeric epoxy. The resulting material may have a generally linear backbone, foaming and curing capability and flame retardant properties.

公开(公告)号：US20240270788A1

公开(公告)日：2024-08-15

申请号：US18603661

申请日：2024-03-13

申请人： AMGEN INC.

发明人： Rizwan SHARNEZ ,  William TRIEU ,  Marc A. CAPORINI ,  Ron C. Kelly ,  Neill Burt ,  Laura Nicholson ,  Twinkle R. Christian

IPC分类号： C07K1/30 ,  A61K39/395 ,  B01J8/20 ,  B01J8/38 ,  C30B7/00 ,  C30B7/10 ,  C30B30/00 ,  C30B30/02 ,  C30B30/04 ,  G01N24/00 ,  G01N24/08 ,  G01R33/20 ,  G01R33/46

CPC分类号： C07K1/306 ,  A61K39/39591 ,  B01J8/20 ,  B01J8/38 ,  C30B7/00 ,  C30B7/10 ,  C30B30/04 ,  G01N24/087 ,  C30B30/00 ,  C30B30/02 ,  G01N24/00 ,  G01N24/008 ,  G01R33/20 ,  G01R33/46

摘要： Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.

公开(公告)号：US12019130B2

公开(公告)日：2024-06-25

申请号：US17465895

申请日：2021-09-03

申请人： Massachusetts Institute of Technology

发明人： Dirk Robert Englund

IPC分类号： G01R33/46 ,  G01R33/28 ,  G01R33/31 ,  G01R33/32

CPC分类号： G01R33/46 ,  G01R33/282 ,  G01R33/31 ,  G01R33/323

摘要： Chemical-shift nuclear magnetic resonance (NMR) spectroscopy involves measuring the effects of chemical bonds in a sample on the resonance frequencies of nuclear spins in the sample. Applying a magnetic field to the sample causes the sample nuclei to emit alternating current magnetic fields that can be detected with color centers, which can act as very sensitive magnetometers. Cryogenically cooling the sample increases the sample's polarization, which in turn enhances the NMR signal strength, making it possible to detect net nuclear spins for very small samples. Flash-heating the sample or subjecting it to a magic-angle-spinning magnetic field (instead of a static magnetic field) eliminates built-in magnetic field inhomogeneities, improving measurement sensitivity without degrading the sample polarization. Tens to hundreds of small, cryogenically cooled sample chambers can be integrated in a semiconductor substrate interlaced with waveguides that contain color centers for optically detected magnetic resonance measurements of the samples' chemical-shift NMR frequencies.

公开(公告)号：US12013354B2

公开(公告)日：2024-06-18

申请号：US17312893

申请日：2019-12-19

申请人： The Regents of the University of California

发明人： Norman Ying Yao ,  Raymond Jeanloz ,  Thomas Mittiga ,  Prabudhya Bhattacharyya ,  Thomas J. Smart ,  Francisco Machado ,  Bryce Kobrin ,  Soonwon Choi ,  Joel Moore ,  Satcher Hsieh ,  Chong Zu

IPC分类号： G01N23/20041 ,  C01B32/28 ,  G01N3/12 ,  G01R33/46

CPC分类号： G01N23/20041 ,  C01B32/28 ,  G01N3/12 ,  G01R33/46 ,  G01N2203/0488

摘要： A pressure chamber has a chamber wall. The chamber wall includes a sensor integrated within the chamber wall, wherein the sensor integrated in the chamber wall comprises defects. A method of determining an effect of pressure on a material is further described. The method includes applying pressure to a material within a pressure chamber and to a pressure chamber wall of the pressure chamber, where the pressure chamber wall has defects. A signal from the defects is sensed while the material and the pressure chamber wall are under pressure. A property of the material is determined based on the sensed signal.

公开(公告)号：US11969239B2

公开(公告)日：2024-04-30

申请号：US16743418

申请日：2020-01-15

申请人： Siemens Healthcare GmbH

发明人： Bin Lou ,  Benjamin L. Odry

IPC分类号： A61B5/055 ,  G01R33/46 ,  G01R33/50 ,  G01R33/563 ,  G06T7/00 ,  G01R33/34

CPC分类号： A61B5/055 ,  G01R33/46 ,  G01R33/50 ,  G01R33/56341 ,  G06T7/0012 ,  G01R33/34084

摘要： Brain tumor or other tissue classification and/or segmentation is provided based on from multi-parametric MRI. MRI spectroscopy, such as in combination with structural and/or diffusion MRI measurements, are used to classify. A machine-learned model or classifier distinguishes between the types of tissue in response to input of the multi-parametric MRI. To deal with limited training data for tumors, a patch-based system may be used. To better assist physicians in interpreting results, a confidence map may be generated using the machine-learned classifier.

公开(公告)号：US11958882B2

公开(公告)日：2024-04-16

申请号：US16494165

申请日：2018-03-14

申请人： AMGEN INC.

发明人： Rizwan Sharnez ,  William Trieu ,  Marc A. Caporini ,  Ron C. Kelly ,  Neill Burt ,  Laura Nicholson ,  Twinkle R. Christian

IPC分类号： C30B7/10 ,  A61K39/395 ,  B01J8/20 ,  B01J8/38 ,  C07K1/30 ,  C30B7/00 ,  C30B30/04 ,  G01N24/08 ,  C30B30/00 ,  C30B30/02 ,  G01N24/00 ,  G01R33/20 ,  G01R33/46

CPC分类号： C07K1/306 ,  A61K39/39591 ,  B01J8/20 ,  B01J8/38 ,  C30B7/00 ,  C30B7/10 ,  C30B30/04 ,  G01N24/087 ,  C30B30/00 ,  C30B30/02 ,  G01N24/00 ,  G01N24/008 ,  G01R33/20 ,  G01R33/46

摘要： Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.

公开(公告)号：US20230152256A1

公开(公告)日：2023-05-18

申请号：US18149233

申请日：2023-01-03

申请人： UNIVERSITY OF MARYLAND, BALTIMORE

发明人： Yihua (Bruce) YU ,  Marc B. TARABAN

IPC分类号： G01N24/08 ,  G01R33/46 ,  G01N33/15

CPC分类号： G01N24/084 ,  G01R33/46 ,  G01N33/15 ,  G01N24/085

摘要： A method of using the transverse relaxation rate (R2) of solvent NMR signal to detect filling errors of an alum-containing product in real-time in-line during manufacturing, for example during a fill-finish unit operation. This technique can be used for quality control in vaccine manufacturing to ensure the delivery of the correct concentration of alum-containing product to the product container such as a vial or pre-filled syringe.

公开(公告)号：US20190055332A1

公开(公告)日：2019-02-21

申请号：US15677507

申请日：2017-08-15

申请人： The Goodyear Tire & Rubber Company

发明人： Stefan MECKING ,  Margaret Flook VIELHABER ,  Hannes LEICHT ,  Julia BAUER ,  Inigo Gottker genannt SCHNETMANN

IPC分类号： C08F36/14 ,  C08F36/06 ,  C08F36/08

CPC分类号： C08F36/14 ,  C08F4/52 ,  C08F36/06 ,  C08F36/08 ,  C08F136/06 ,  C08F136/08 ,  C08F236/045 ,  C08F236/06 ,  C08F236/08 ,  C08F236/14 ,  C08F2500/21 ,  C08F2800/20 ,  C08F2810/20 ,  G01R33/46 ,  C08F36/04 ,  C08F4/545

摘要： The present invention is directed to a stereoregular functionalized elastomer represented by poly(M1 co M2), wherein the functionalized elastomer comprises a microstructure selected from the group consisting of microstructures having at least 90 percent by weight of monomer residues in trans 1,4-configuration, and microstructures having at least 80 percent by weight of monomer residues in cis 1,4-configuration; wherein M1 is selected from the group consisting of isoprene and 1,3-butadiene; and M2 is of formula 4 wherein R6 is a covalent bond, phenylene, a linear or branched alkane diyl group containing 1 to 10 carbon atoms, or a combination of one or more phenylene groups and one or more linear or branched alkane diyl groups containing 1 to 10 carbon atoms; R7 is hydrogen or a linear or branched alkyl group containing 1 to 10 carbon atoms; X1 is selected from formulas 5 and 6 wherein R8 and R9 are independently trialkylsilyl, phenyl or a linear or branched alkyl group containing 1 to 10 carbon atoms, or one of R8 and R9 is hydrogen and the other is phenyl or a linear or branched alkyl group containing 1 to 10 carbon atoms, or R8 and R9 taken together with the nitrogen atom represent a nitrogen containing heterocyclic group containing from 4 to 12 carbon atoms; and X2 is a sulfur atom or a structure of formula 7 or 8 wherein when X2 is of formula 8, the S atom of formula 8 is adjacent to the phenyl ring of formula 6 and the N atom of formula 8 is adjacent to R6.

公开(公告)号：US20190033238A1

公开(公告)日：2019-01-31

申请号：US15661852

申请日：2017-07-27

申请人： Saudi Arabian Oil Company

发明人： Ahmad Mubarak Al-Harbi ,  Hyung Tae Kwak ,  Jun Gao

IPC分类号： G01N24/08 ,  G01N1/34 ,  G01R33/46

CPC分类号： G01N24/081 ,  G01N1/34 ,  G01R33/448 ,  G01R33/46

摘要： Methods estimating a property of a porous media include: saturating a sample of the porous media; spinning the sample in a centrifuge with a first end of the sample closer to an axis of rotation of the centrifuge than a second end of the sample; obtaining a first estimate of the first property; saturating the sample of the porous media; spinning the sample in a centrifuge with the second end of the sample closer to the axis of rotation of the centrifuge than the first end of the sample; obtaining a second estimate of the first property; and determining the second property of the porous media based at least in part on the first estimate of the first property and the second estimate of the first property. The first property can be a T2 distribution and the second property can be a T2 cutoff

公开(公告)号：US20180220949A1

公开(公告)日：2018-08-09

申请号：US15868996

申请日：2018-01-11

申请人： Pablo Jose Prado

发明人： Pablo Jose Prado

IPC分类号： A61B5/00 ,  G01R33/46 ,  A61B5/055

CPC分类号： A61B5/4244 ,  A61B5/055 ,  A61B5/0555 ,  A61B5/4872 ,  G01R33/3802 ,  G01R33/3808 ,  G01R33/383 ,  G01R33/46 ,  G01R33/4828

摘要： An apparatus for measuring liver fat content and/or iron content non-invasively in vivo using unilateral NMR technology is disclosed. The apparatus comprises a unilateral NMR probe positioned against or in the proximity of the body. The probe generates static and RF magnetic fields to measure NMR signals at selected depths into the body. The apparatus further comprises a unilateral magnet and a unilateral antenna placed between a magnet and the body or around the magnet. The unilateral antenna is used to attain NMR signals. The measurement of NMR signals at a single position with a single frequency determines fat content on a specific volume inside the liver. The measurement of NMR signals at a single position with two or more frequencies determines iron content on a specific volume inside the liver.