公开(公告)号：US10144720B2

公开(公告)日：2018-12-04

申请号：US15120802

申请日：2015-03-13

Applicant: Givaudan SA

Inventor： Paul Nicholas Davey ,  Martin Alan Lovchik ,  Andreas Goeke ,  Krisztian Lorincz ,  Florian Toth ,  Levente Ondi

IPC: C07D313/00 ,  C07C67/343 ,  C07C69/734 ,  C11B9/00

Abstract: A method of forming a macrocyclic musk compound comprising the steps of:— i) cross-metathesizing a first olefin and a second olefin in the presence of a homogeneous transition metal catalyst comprising an alkylidene ligand, to form a statistical mixture of a hetero-dimer intermediate of said first and second terminal olefin, and homo-dimers ii) separating the hetero-dimer from the statistical mixture of hetero- and homo-dimers iii) and cyclizing the hetero-dimer intermediate to form the macrocyclic musk compound.