公开(公告)号：US10343971B2

公开(公告)日：2019-07-09

申请号：US16071739

申请日：2017-02-15

Applicant: GIVAUDAN SA

Inventor： Andreas Goeke ,  Felix Flachsmann ,  Dominique Lelievre ,  Andreas Natsch ,  Francis Voirol ,  Yue Zou ,  Thierry Granier

IPC: C07C69/608 ,  C07C229/04 ,  C07C323/52 ,  A61Q13/00 ,  A61K8/37 ,  A61K8/46 ,  C07C69/533 ,  C07C69/56

Abstract: A compound of formula I wherein R1, R2, R3 and R4 can be independently selected from H or Me, n=0, 1, the dotted lines are indicating single bonds, or in case n=0 an isolated double bond at position 3′, or in case n=1 an isolated double bond at position 3′ or 4′, and the wavy bond is indicating an unspecified configuration of the adjacent double bond. Said compounds, as well as precursors capable to generate said compounds, are useful as fragrance ingredients.

公开(公告)号：US08691746B2

公开(公告)日：2014-04-08

申请号：US13647161

申请日：2012-10-08

Applicant: Givaudan SA

Inventor： Andreas Goeke ,  Yue Zou

IPC: C07C47/45 ,  C07C47/445 ,  C07C35/18 ,  C07C35/27

CPC classification number: C07C45/75 ,  A23L27/2024 ,  A23L27/2026 ,  A23L27/2028 ,  A23L27/203 ,  A23L27/2052 ,  C07C33/14 ,  C07C45/292 ,  C07C47/445 ,  C07C47/45 ,  C07C49/553 ,  C07C49/557 ,  C07C251/44 ,  C07C403/02 ,  C07C2601/16 ,  C07C2602/08 ,  C07C2602/10 ,  C11B9/0034 ,  C11B9/0042 ,  C11B9/0049 ,  C11B9/0053 ,  C11B9/0057 ,  C11B9/0076 ,  C11B9/008 ,  C11B9/0088

Abstract: The present invention relates to a process for the production of formyl cyclohexene derivatives which are suitable as odorants as such or as intermediates for the preparation of further odorants. In particular the present invention relates to a domino-methylenation-Diels-Alder reaction of α,β-unsaturated aldehydes using formaldehyde in the presence of 1,3-butadienes.

Abstract translation: 本发明涉及一种生产甲酰基环己烯衍生物的方法，其适合作为气味，或作为制备其它气味剂的中间体。 特别地，本发明涉及在1,3-丁二烯存在下使用甲醛的α，β-不饱和醛的多甲基亚甲基化 - 狄尔斯 - 阿尔德反应。

公开(公告)号：US10400193B2

公开(公告)日：2019-09-03

申请号：US15746320

申请日：2016-07-27

Applicant: GIVAUDAN SA

Inventor： Yue Zou ,  Andreas Goeke ,  Dominique Lelievre ,  Jie Liu

IPC: C11D3/50 ,  C11B9/00 ,  A61K8/34 ,  A61Q5/02 ,  A61Q13/00 ,  C07C33/025

Abstract: 2,4,7-Trimethyloct-6-en-1-ol which is useful as a fragrance ingredient.

公开(公告)号：US20150038386A1

公开(公告)日：2015-02-05

申请号：US14117983

申请日：2012-05-25

Applicant: GIVAUDAN SA

Inventor： Hai-Shan Dang ,  Andreas Goeke ,  Yue Zou

IPC: C11B9/00 ,  A61Q5/02 ,  A61Q19/10 ,  C11D3/50 ,  A61K8/34

CPC classification number: C11B9/003 ,  A61K8/34 ,  A61K2800/10 ,  A61Q5/02 ,  A61Q19/10 ,  C07C33/02 ,  C07C33/05 ,  C07C2601/02 ,  C11B9/0015 ,  C11D3/50

Abstract: Compounds of formula (I) wherein R is hydrogen and the bond between C-2 and C-3 together with the dotted line represents a double bond, or R is —CH2— and together with C-2 and C-3 represents a cyclopropane ring and the bond between C-2 and C-3 together with the dotted line represents a single bond, having floral rosy odor notes, their use as fragrance and perfumed products comprising them.

Abstract translation: 式（I）的化合物，其中R是氢，C-2和C-3之间的键与虚线一起表示双键，或R是-CH 2 - ，并且与C-2和C-3一起代表环丙烷 环和C-2和C-3之间的键与虚线一起表示单键，具有花香玫瑰香味，它们作为香料的用途和包含它们的加香产品。

公开(公告)号：US11485985B2

公开(公告)日：2022-11-01

申请号：US16765649

申请日：2018-11-21

Applicant: Givaudan SA

Inventor： Andreas Goeke ,  Julie Charpentier ,  Boris Schilling ,  Fridtjof Schröder

IPC: C12P7/38 ,  A23L27/20 ,  A23L27/10 ,  C07C45/27 ,  C12N9/88

Abstract: A process for producing rotundone from α-guaiene, in particular by oxidation of the C(3) position, wherein the α-guaiene is produced from a precursor by a sesquiterpene synthase. The sesquiterpene synthase is produced in a microorganism.

公开(公告)号：US10760033B2

公开(公告)日：2020-09-01

申请号：US15516602

申请日：2015-11-12

Applicant: GIVAUDAN SA

Inventor： Tse Chi-Lam ,  Martin Alan Lovchik ,  Simon Ellwood ,  Andreas Goeke

IPC: C07C45/74 ,  C11B9/00 ,  C07C45/49 ,  C07C17/12 ,  C07C45/62 ,  C07C43/307 ,  C07C49/213 ,  C11D3/20 ,  C11D3/50

Abstract: The regio-selective functionalization of a dialkyl benzene compound wherein the ratio of the compound functionalized at position (a) to the compound functionalized at the position (b) is at least 70:30, more particularly at least 80:20, still more particularly at least 85:15, and still more particularly at least 90:10, characterised in that the substituent R is an isobutyl group.

公开(公告)号：US20190023643A1

公开(公告)日：2019-01-24

申请号：US16071739

申请日：2017-02-15

Applicant: GIVAUDAN SA

Inventor： Andreas Goeke ,  Felix FLACHSMANN ,  Dominique LELIEVRE ,  Andreas NATSCH ,  Francis VOIROL ,  Yue ZOU

IPC: C07C69/608 ,  C07C229/04 ,  C07C323/52 ,  A61Q13/00

CPC classification number: C07C69/608 ,  A61K8/37 ,  A61K8/46 ,  A61Q13/00 ,  C07C69/533 ,  C07C69/56 ,  C07C229/04 ,  C07C323/52 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16

Abstract: A compound of formula I wherein R1, R2, R3 and R4 can be independently selected from H or Me, n=0, 1, the dotted lines are indicating single bonds, or in case n=0 an isolated double bond at position 3′, or in case n=1 an isolated double bond at position 3′ or 4′, and the wavy bond is indicating an unspecified configuration of the adjacent double bond. Said compounds, as well as precursors capable to generate said compounds, are useful as fragrance ingredients.

公开(公告)号：US12116548B2

公开(公告)日：2024-10-15

申请号：US17429038

申请日：2020-02-19

Applicant: GIVAUDAN SA

Inventor： Thierry Granier ,  Julie Charpentier ,  Gerhard Brunner ,  Sandro Dossenbach ,  Felix Flachsmann ,  Andreas Goeke

IPC: C11B9/00 ,  A23L27/20

CPC classification number: C11B9/0049 ,  A23L27/203

Abstract: Compounds according to formula I in the form of any one of its stereoisomers or a mixture thereof






wherein
is indicating a single bond or a double bond, and
the compound has overall one carbon-carbon double bond or no carbon-carbon double bond at all,
and their use as flavor or fragrance ingredient.

公开(公告)号：US10450532B2

公开(公告)日：2019-10-22

申请号：US15528242

申请日：2015-12-08

Applicant: GIVAUDAN SA

Inventor： Andreas Goeke ,  Felix Flachsmann ,  Martin Alan Lovchik

IPC: A61Q13/00 ,  A61K8/00 ,  C11B9/00 ,  C07C47/263 ,  C07C33/046

Abstract: A compound represented by the formula I wherein is indicating a double bond either at C4 or at C5, or single bonds, R1, R2, R3, R4 are independently selected from H or Me, and R5, R6 are independently selected from Me or Et, and wherein the compound is not 9-hydroxy-5,9-dimethyldec-4-enal or 9-hydroxy-5,9-dimethyldecanal. Said compounds are useful as perfume ingredients in personal care and household care products.

公开(公告)号：US10144720B2

公开(公告)日：2018-12-04

申请号：US15120802

申请日：2015-03-13

Applicant: Givaudan SA

Inventor： Paul Nicholas Davey ,  Martin Alan Lovchik ,  Andreas Goeke ,  Krisztian Lorincz ,  Florian Toth ,  Levente Ondi

IPC: C07D313/00 ,  C07C67/343 ,  C07C69/734 ,  C11B9/00

Abstract: A method of forming a macrocyclic musk compound comprising the steps of:— i) cross-metathesizing a first olefin and a second olefin in the presence of a homogeneous transition metal catalyst comprising an alkylidene ligand, to form a statistical mixture of a hetero-dimer intermediate of said first and second terminal olefin, and homo-dimers ii) separating the hetero-dimer from the statistical mixture of hetero- and homo-dimers iii) and cyclizing the hetero-dimer intermediate to form the macrocyclic musk compound.