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公开(公告)号：US10308668B2
公开(公告)日：2019-06-04
申请号：US15792251
申请日：2017-10-24
发明人： Michael Richard Kevin Alley , Vincent Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要： Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US20210053996A1
公开(公告)日：2021-02-25
申请号：US17018301
申请日：2020-09-11
发明人： Carlos Alemparte-Gallardo , Michael Richard Kevin (Dickon) Alley , David Barros-Aguirre , Ilaria Giordano , Vincent Hernandez , Xianfeng Li , Jacob J. Plattner
摘要： Substituted benzoxaboroles whose structure comprises Formula (III), wherein R3 is selected from —CH3, —CII2CII3, —CII2═CII2, —CII2CII2CII3, —CH(CH3)2, —CH2CH2═CH2, and cyclopropyl, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, and —CH(CH3)2; compositions containing such compounds, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US10858376B2
公开(公告)日：2020-12-08
申请号：US16695253
申请日：2019-11-26
发明人： Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要： Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US10774096B2
公开(公告)日：2020-09-15
申请号：US15550693
申请日：2016-02-12
发明人： Carlos Alemparte-Gallardo , Michael Richard Kevin (Dickon) Alley , David Barros-Aguirre , Ilaria Giordano , Vincent Hernandez , Xianfeng Li , Jacob J. Plattner
摘要： Substituted benzoxaboroles whose structure comprises Formula (III), wherein R3 is selected from —CH3, —CH2CH3, —CH2═CH2, —CH2CH2CH3, —CH(CH3)2, —CH2CH2═CH2, and cyclopropyl, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, and —CH(CH3)2; compositions containing such compounds, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US10526352B2
公开(公告)日：2020-01-07
申请号：US16385547
申请日：2019-04-16
发明人： Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要： Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US20190241586A1
公开(公告)日：2019-08-08
申请号：US16385547
申请日：2019-04-16
发明人： Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要： Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US11214582B2
公开(公告)日：2022-01-04
申请号：US17018301
申请日：2020-09-11
发明人： Carlos Alemparte-Gallardo , Michael Richard Kevin (Dickon) Alley , David Barros-Aguirre , Ilaria Giordano , Vincent Hernandez , Xianfeng Li , Jacob J. Plattner
摘要： Substituted benzoxaboroles whose structure comprises Formula (III), wherein R3 is selected from —CH3, —CII2CII3, —CII2═CII2, —CII2CII2CII3, —CH(CH3)2, —CH2CH2═CH2, and cyclopropyl, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, and —CH(CH3)2; compositions containing such compounds, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US20210053999A1
公开(公告)日：2021-02-25
申请号：US17089058
申请日：2020-11-04
发明人： Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要： Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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公开(公告)号：US20200095266A1
公开(公告)日：2020-03-26
申请号：US16695253
申请日：2019-11-26
发明人： Michael Richard Kevin Alley , Vincent S. Hernandez , Jacob J. Plattner , Xianfeng Li , David Barros-Aguirre , Ilaria Giordano
摘要： Compounds of Formula II, wherein X is selected from chloro, fluoro, bromo and iodo, R1 and R2 are each independently selected from H, —CH3, —CH2CH3, —CH2CH2CH3, or —CH(CH3)2; compositions containing them, their use in therapy, including their use as anti-mycobacterial agents, for example in the treatment of a mycobacterial infection in a mammal, and methods for the preparation of such compounds, are provided.
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