公开(公告)号：US20190382381A1

公开(公告)日：2019-12-19

申请号：US16547734

申请日：2019-08-22

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Linda N. CASILLAS ,  John David HARLING ,  Afjal Hussain MIAH ,  Mark David RACKHAM ,  Ian Edward David SMITH

IPC: C07D403/14 ,  A61P29/00 ,  C07D487/04 ,  C07D417/14 ,  C07D401/14

Abstract: The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of RIP2 kinase, including degrading RIP2 kinase, the treatment of diseases and conditions mediated by the RIP2 kinase, in particular for the treatment of inflammatory diseases or conditions.

公开(公告)号：US20190119271A1

公开(公告)日：2019-04-25

申请号：US16094564

申请日：2017-04-18

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Linda N. CASILLAS ,  John David HARLING ,  Afjal Hussain MIAH ,  Mark David RACKHAM ,  Ian Edward David Smith

IPC: C07D471/04 ,  C07D417/14 ,  C07D471/10 ,  C07D519/00

Abstract: The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of RIP2 kinase, including degrading RIP2 kinase, the treatment of diseases and conditions mediated by the RIP2 kinase, in particular for the treatment of inflammatory diseases or conditions.

公开(公告)号：US20180134688A1

公开(公告)日：2018-05-17

申请号：US15568025

申请日：2016-04-20

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Linda N. CASILLAS ,  John David HARLING ,  Afjal Hussain MIAH ,  Mark David RACKHAM ,  Ian Edward David SMITH

IPC: C07D403/14 ,  C07D401/14 ,  C07D487/04 ,  C07D417/14 ,  A61P29/00

CPC classification number: C07D403/14 ,  A61P29/00 ,  C07D401/14 ,  C07D417/14 ,  C07D487/04

Abstract: The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of RIP2 kinase, including degrading RIP2 kinase, the treatment of diseases and conditions mediated by the RIP2 kinase, in particular for the treatment of inflammatory diseases or conditions.