公开(公告)号：US11773078B2

公开(公告)日：2023-10-03

申请号：US17054491

申请日：2019-05-10

Applicant: Glaxosmithkline Intellectual Property Development Limited

Inventor： Jeffrey Michael Axten ,  Mui Cheung ,  Michael P. Demartino ,  Huiping Amy Guan ,  Yan Hu ,  Aaron Bayne Miller ,  Donghui Qin ,  Chengde Wu ,  Zhiliu Zhang ,  Xiaojuan Lin

IPC: C07D401/12 ,  C07D401/14 ,  A61P11/00 ,  C07D211/26 ,  C07D487/08

CPC classification number: C07D401/14 ,  A61P11/00 ,  C07D211/26 ,  C07D401/12 ,  C07D487/08

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of furin, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of fibrotic diseases, including pulmonary fibrosis, renal fibrosis, liver fibrosis, skin fibrosis, ocular fibrosis, cardiac fibrosis, and other miscellaneous fibrotic conditions. The disclosed compounds may also be useful for treating other furin-mediated conditions, including but not limited to, hypertension, cancer, infectious diseases, and genetic disorders (e.g., cystic fibrosis (CF)), and neurodegenerative disorders.

公开(公告)号：US20220315556A1

公开(公告)日：2022-10-06

申请号：US17054491

申请日：2019-05-10

Applicant: Glaxosmithkline Intellectual Property Development Limited

Inventor： Jeffrey Michael Axten ,  Mui Cheung ,  Michael P. Demartino ,  Huiping Amy Guan ,  Yan Hu ,  Aaron Bayne Miller ,  Donghui Qin ,  Chengde Wu ,  Zhiliu Zhang ,  Xiaojuan Lin

IPC: C07D401/14 ,  A61P11/00 ,  C07D401/12 ,  C07D211/26 ,  C07D487/08

Abstract: This invention relates to novel compounds according to Formula (I) which are inhibitors of furin, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of fibrotic diseases, including pulmonary fibrosis, renal fibrosis, liver fibrosis, skin fibrosis, ocular fibrosis, cardiac fibrosis, and other miscellaneous fibrotic conditions. The disclosed compounds may also be useful for treating other furin-mediated conditions, including but not limited to, hypertension, cancer, infectious diseases, and genetic disorders (e.g., cystic fibrosis (CF)), and neurodegenerative disorders.