公开(公告)号：US20100233824A1

公开(公告)日：2010-09-16

申请号：US12669213

申请日：2008-07-11

申请人： Godefridus Johannes Verhoeckx ,  Henkrik Sibolt Van Damme ,  Jeroen Hans Nieuwenhuis ,  Sergei Shulepov ,  Johannes Wilhelmus Weekamp ,  Mara Johanna Jacoba Sijbers ,  Harold Johannes Antonius Brans ,  Femke Karina De Theije ,  Albert Hendrik Jan Immink

发明人： Godefridus Johannes Verhoeckx ,  Henkrik Sibolt Van Damme ,  Jeroen Hans Nieuwenhuis ,  Sergei Shulepov ,  Johannes Wilhelmus Weekamp ,  Mara Johanna Jacoba Sijbers ,  Harold Johannes Antonius Brans ,  Femke Karina De Theije ,  Albert Hendrik Jan Immink

IPC分类号： G01N33/53 ,  G01N33/00 ,  B23P17/04

CPC分类号： B01L3/502715 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/0627 ,  B01L2300/0636 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0487 ,  Y10T29/49826

摘要： A microfluidic reactor arrangement (100) for use in detecting an analyte in a fluid sample (106) is described. The reactor arrangement is provided with a reagent providing means such that the reagent can be introduced after assembly of the reactor arrangement. The latter can be performed by introducing the reagent in the form of a solution or a dispersion and fixing it on a holding means (118) by removal of the liquid, i.e. by drying, the holding means comprising the reagent in a solid version in the detector chamber. Prior to the introduction of the reagent, components of the reactor arrangement already present, such as the sample inlet can be hydrophilised by a wetting hydrophilising technique. The invention relates to a manufacturing technique as well as to the resulting product. The invention furthermore relates to functionalizing of the reactor arrangement with a particular reagent for particular applications. The latter can be performed well after fabrication and assembly of the major reactor arrangement components.

摘要翻译： 描述了用于检测流体样品（106）中的分析物的微流体反应器装置（100）。 反应器装置设置有试剂提供装置，使得可以在组装反应器装置之后引入试剂。 后者可以通过将试剂以溶液或分散体的形式引入并通过除去液体将其固定在保持装置（118）上来进行，即通过干燥包含试剂的固定装置以固体形式在 检测器室。 在引入试剂之前，已经存在的反应器装置的组分（例如样品入口）可以通过润湿亲水化技术亲水化。 本发明涉及制造技术以及所得到的产品。 本发明还涉及用于特定应用的具有特定试剂的反应器装置的功能化。 后者可以在主要反应器布置部件的制造和组装之后很好地进行。

公开(公告)号：US08339608B2

公开(公告)日：2012-12-25

申请号：US12740148

申请日：2008-10-30

申请人： Harold Johannes Antonius Brans ,  Albert Hendrik Jan Immink ,  Hendrik Sibolt Van Damme ,  Mara Johanna Jacoba Sijbers

发明人： Harold Johannes Antonius Brans ,  Albert Hendrik Jan Immink ,  Hendrik Sibolt Van Damme ,  Mara Johanna Jacoba Sijbers

IPC分类号： G01N21/55

CPC分类号： G01N21/552 ,  G01N15/0612 ,  G01N21/648 ,  G01N2015/0693

摘要： A method of detecting redispersion of particles into a solution using for example FTIR. The method including providing a sensor surface with dry particles; illuminating the sensor surface with light along a first optical path and detecting the light reflected by the sensor surface; providing a liquid to a volume in contact with the sensor surface; and detecting the reflected light while the dry particles redisperse into the liquid. The angle between the first optical path and the sensor surface fulfils the condition of total internal reflection. Further, an FTIR cartridge may be provided for use in said method. The cartridge including a sensor surface accessible for FTIR detection including at least one binding area wherein label particles are situated.

摘要翻译： 使用例如FTIR检测颗粒再次分散到溶液中的方法。 该方法包括向传感器表面提供干燥颗粒; 用沿着第一光路的光照射传感器表面并检测由传感器表面反射的光; 向与传感器表面接触的体积提供液体; 并且当干燥颗粒再分散到液体中时检测反射光。 第一光路和传感器表面之间的角度满足全内反射的条件。 此外，可以提供用于所述方法的FTIR盒。 该盒包括可用于FTIR检测的传感器表面，包括标签颗粒所在的至少一个结合区域。

公开(公告)号：US20230191052A1

公开(公告)日：2023-06-22

申请号：US17964133

申请日：2022-10-12

申请人： Harold Johannes Antonius Brans ,  Kiran Hamilton J. Dellimore ,  Samer Bou Jawde ,  Pascal de Graaf

发明人： Harold Johannes Antonius Brans ,  Kiran Hamilton J. Dellimore ,  Samer Bou Jawde ,  Pascal de Graaf

IPC分类号： A61M16/00 ,  A61M16/06

CPC分类号： A61M16/022 ,  A61M16/0003 ,  A61M16/0672 ,  A61M16/0096

摘要： Provided are concepts for controlling a high flow nasal therapy (HFNT) device used by a subject. In particular, physiological and movement parameter values of the subject are leveraged in order to generate a control signal for the HFNT device. These parameters may indicate an activity level of the subject, as well as the condition of the subject, providing information useful for setting appropriate operating conditions of the HFNT device. Thus, a means for automatically controlling a HFNT device based on needs of the subject may be provided, improving subject comfort during therapy, and ease of use of the HFT device.