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公开(公告)号：US08288351B2
公开(公告)日：2012-10-16
申请号：US12082224
申请日：2008-04-08
申请人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, Jr. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
发明人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, Jr. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
IPC分类号： C07K7/18
摘要： The present invention relates to composition of matter involving bradykinin B1 receptor antagonist peptides conjugated to a univalent vehicle, including peptides conjugated to univalent PEG. These compositions can be used as therapeutics or prophylactics against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor.
摘要翻译： 本发明涉及与单价载体缀合的缓激肽B1受体拮抗剂肽的物质组合物，包括与一价PEG缀合的肽。 这些组合物可用作与缓激肽B1受体连接的疾病或病症例如炎症或疼痛的治疗剂或预防剂。
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公开(公告)号：US20090137483A1
公开(公告)日：2009-05-28
申请号：US12082224
申请日：2008-04-08
申请人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
发明人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
摘要： The present invention relates to composition of matter involving bradykinin B1 receptor antagonist peptides conjugated to a univalent vehicle, including peptides conjugated to univalent PEG. These compositions can be used as therapeutics or prophylactics against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor.
摘要翻译： 本发明涉及与单价载体缀合的缓激肽B1受体拮抗剂肽的物质组合物，包括与一价PEG缀合的肽。 这些组合物可用作与缓激肽B1受体连接的疾病或病症例如炎症或疼痛的治疗剂或预防剂。
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公开(公告)号：US20090137452A1
公开(公告)日：2009-05-28
申请号：US12082219
申请日：2008-04-08
申请人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
发明人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
摘要： The present invention relates to composition of matter involving bradykinin B1 receptor antagonist peptides conjugated to a multivalent vehicle, including peptides conjugated to multivalent PEG. These compositions can be used as therapeutics or prophylactics against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor.
摘要翻译： 本发明涉及涉及与多价载体缀合的缓激肽B1受体拮抗剂肽的物质组合物，包括与多价PEG缀合的肽。 这些组合物可用作与缓激肽B1受体连接的疾病或病症例如炎症或疼痛的治疗剂或预防剂。
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公开(公告)号：US08278280B2
公开(公告)日：2012-10-02
申请号：US12082219
申请日：2008-04-08
申请人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, Jr. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
发明人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, Jr. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
IPC分类号： C07K7/18
摘要： The present invention relates to composition of matter involving bradykinin B1 receptor antagonist peptides conjugated to a multivalent vehicle, including peptides conjugated to multivalent PEG. These compositions can be used as therapeutics or prophylactics against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor.
摘要翻译： 本发明涉及涉及与多价载体缀合的缓激肽B1受体拮抗剂肽的物质组合物，包括与多价PEG缀合的肽。 这些组合物可用作与缓激肽B1受体连接的疾病或病症例如炎症或疼痛的治疗剂或预防剂。
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公开(公告)号：US20090048149A1
公开(公告)日：2009-02-19
申请号：US12082395
申请日：2008-04-09
申请人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
发明人： Gordon Ng , Yue-Sheng Li , Colin V. Gegg , Benny C. Askew, JR. , Thomas Storz , Yuelie Lu , Derin C. D'Amico , Mark A. Jarosinski , Chuan-Fa Liu , Qi Huang
摘要： The present invention relates to a method of treating, preventing, or ameliorating a disease or condition associated with or mediated by B1 activity that involves administering a composition of matter containing bradykinin B1 receptor antagonist peptides conjugated to a multivalent vehicle, including peptides conjugated to multivalent PEG. The method can be used therapeutically or prophylactically against diseases or conditions, such as inflammation or pain, linked to the bradykinin B1 receptor.
摘要翻译： 本发明涉及一种治疗，预防或改善与B1活性相关或介导的疾病或病症的方法，该方法包括给予包含与多价载体缀合的缓激肽B1受体拮抗剂肽的物质组合物，包括与多价PEG缀合的肽 。 该方法可以治疗性或预防性地用于与缓激肽B1受体连接的疾病或病症，例如炎症或疼痛。
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公开(公告)号：US07605120B2
公开(公告)日：2009-10-20
申请号：US10972236
申请日：2004-10-21
摘要： The present invention relates to certain biologically active peptides and conjugated peptides which can be used as therapeutics or prophylactics against diseases or conditions linked to B1 as the causative agent. In a preferred embodiment of the invention biologically active PEG-conjugated peptides are provided. In one aspect of the present invention, pharmacologically active PEG-conjugated peptides of the present invention are useful to treat inflammation or pain.
摘要翻译： 本发明涉及某些生物活性肽和缀合肽，其可以用作治疗剂或预防药物，其与作为致病剂的B1连接的疾病或病症。 在本发明的优选实施方案中，提供生物活性PEG-缀合的肽。 在本发明的一个方面，本发明的药理学活性的PEG-缀合的肽可用于治疗炎症或疼痛。
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