FUSION PROTEIN CAPABLE OF BINDING VEGF-A AND TNF-ALPHA
    2.
    发明申请
    FUSION PROTEIN CAPABLE OF BINDING VEGF-A AND TNF-ALPHA 有权
    融合蛋白能够结合VEGF-A和TNF-α

    公开(公告)号:US20100150926A1

    公开(公告)日:2010-06-17

    申请号:US12636013

    申请日:2009-12-11

    摘要: The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide comprising: (a) a nucleotide sequence encoding a TNFR2 component and VEGFR1 component operatively linked to (b) a nucleotide sequence encoding a multimerizing component, wherein the TNFR2 component consists essentially of a nucleotide sequence encoding the amino acid sequences of cystein rich domain 1, cystein rich domain 2, cystein rich domain 3, and cystein rich domain 4 of the extracellular domain of TNFR2, and wherein the VEGFR1 component consists essentially of a nucleotide sequence encoding the amino acid sequences of Ig-like domain 2 of the extracellular domain of VEGFR1.

    摘要翻译: 本申请描述了编码能够同时结合VEGF多肽和TNF多肽的多肽的分离的核酸分子,其包含:(a)编码TNFR2组分的核苷酸序列和可操作地连接到(b)编码多聚化成分的核苷酸序列的VEGFR1组分, 其中TNFR2组分基本上由编码TNFR2细胞外结构域的富含半胱氨酸域1,半胱氨酸富含结构域2,半胱氨酸富含结构域3和半胱氨酸富含结构域4的氨基酸序列的核苷酸序列组成,其中VEGFR1组分基本上组成 的编码VEGFR1细胞外结构域的Ig样结构域2的氨基酸序列的核苷酸序列。

    Fusion protein capable of binding VEGF-A and TNF-alpha
    5.
    发明授权
    Fusion protein capable of binding VEGF-A and TNF-alpha 有权
    能够结合VEGF-A和TNF-α的融合蛋白

    公开(公告)号:US08927232B2

    公开(公告)日:2015-01-06

    申请号:US12636013

    申请日:2009-12-11

    摘要: The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide comprising: (a) a nucleotide sequence encoding a TNFR2 component and VEGFR1 component operatively linked to (b) a nucleotide sequence encoding a multimerizing component, wherein the TNFR2 component consists essentially of a nucleotide sequence encoding the amino acid sequences of cystein rich domain 1, cystein rich domain 2, cystein rich domain 3, and cystein rich domain 4 of the extracellular domain of TNFR2, and wherein the VEGFR1 component consists essentially of a nucleotide sequence encoding the amino acid sequences of Ig-like domain 2 of the extracellular domain of VEGFR1.

    摘要翻译: 本申请描述了编码能够同时结合VEGF多肽和TNF多肽的多肽的分离的核酸分子,其包含:(a)编码TNFR2组分的核苷酸序列和可操作地连接到(b)编码多聚化成分的核苷酸序列的VEGFR1组分, 其中TNFR2组分基本上由编码TNFR2细胞外结构域的富含半胱氨酸域1,半胱氨酸富含结构域2,半胱氨酸富含结构域3和半胱氨酸富含结构域4的氨基酸序列的核苷酸序列组成,其中VEGFR1组分基本上组成 的编码VEGFR1细胞外结构域的Ig样结构域2的氨基酸序列的核苷酸序列。

    Chimeric CMP-Ang1 molecule
    8.
    发明授权
    Chimeric CMP-Ang1 molecule 有权
    嵌合CMP-Ang1分子

    公开(公告)号:US07691366B2

    公开(公告)日:2010-04-06

    申请号:US11956291

    申请日:2007-12-13

    申请人: Gou Young Koh

    发明人: Gou Young Koh

    IPC分类号: A61K38/18 C07K14/515

    摘要: The present application describes a fusion molecule that includes coiled coil domain, which renders the molecule soluble and provides potent activity.

    摘要翻译: 本申请描述了包含卷曲螺旋结构域的融合分子,其使分子可溶并提供有效活性。

    Chimeric comp-ang1 molecule
    9.
    发明授权
    Chimeric comp-ang1 molecule 有权
    嵌合comp-ang1分子

    公开(公告)号:US07081443B2

    公开(公告)日:2006-07-25

    申请号:US10273180

    申请日:2002-10-18

    申请人: Gou Young Koh

    发明人: Gou Young Koh

    IPC分类号: C07K14/515 A61K38/18

    摘要: The present application describes a fusion molecule that includes coiled coil domain, which renders the molecule soluble and provides potent activity.

    摘要翻译: 本申请描述了包含卷曲螺旋结构域的融合分子,其使分子可溶并提供有效活性。