公开(公告)号：US20240165116A1

公开(公告)日：2024-05-23

申请号：US18547257

申请日：2022-02-22

Applicant: Graviton Bioscience B.V.

Inventor： Samuel D. Waksal ,  Rui Wu

IPC: A61K31/506 ,  A61P11/00 ,  A61P31/14

CPC classification number: A61K31/506 ,  A61P11/00 ,  A61P31/14

Abstract: The disclosure provides compositions and methods comprising selective inhibitors of Rho-associated coiled-coil kinase 2 (ROCK2) for use in the treatment of viral infections, particularly coro-navirus infections such as SARS-CoV-2, and in the treatment of seguelae resulting from the viral infection, including sequelae resulting from coronavirus infection.