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公开(公告)号：US07371741B2
公开(公告)日：2008-05-13
申请号：US10856340
申请日：2004-05-28
申请人： Gregory E. Agoston , Theresa M. LaVallee , Victor S. Pribluda , Jamshed H. Shah , Anthony M. Treston
发明人： Gregory E. Agoston , Theresa M. LaVallee , Victor S. Pribluda , Jamshed H. Shah , Anthony M. Treston
CPC分类号： C07J41/00
摘要： Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification.
摘要翻译： 用于治疗哺乳动物疾病的组合物和方法，其特征在于不期望的血管生成，其通过施用以下通式的化合物：其中变量在说明书中定义。
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公开(公告)号：US07135581B2
公开(公告)日：2006-11-14
申请号：US09939208
申请日：2001-08-24
申请人： Gregory E. Agoston , Jamshed H. Shah , Kimberly A. Hunsucker , Victor S. Pribluda , Theresa M. LaVallee , Shawn J. Green , Christopher J. Herbstritt , Xiaoguo H. Zhan , Anthony M. Treston
发明人： Gregory E. Agoston , Jamshed H. Shah , Kimberly A. Hunsucker , Victor S. Pribluda , Theresa M. LaVallee , Shawn J. Green , Christopher J. Herbstritt , Xiaoguo H. Zhan , Anthony M. Treston
CPC分类号： C07J1/00
摘要： Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula: wherein the variables are defined in the specification.
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公开(公告)号：US20090105205A1
公开(公告)日：2009-04-23
申请号：US12341068
申请日：2008-12-22
CPC分类号： C07J1/00
摘要： Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: wherein Ra is selected from —OCH3, —OCH2CH3 or —CCCH3; and Z is selected from >C(H)—OH, >C(H)—O-alkyl, >C(H)—O-sulfamate, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.
摘要翻译： 通过施用有效量的下式化合物治疗哺乳动物疾病或特征在于不希望的血管发生的病症的组合物和方法：其中R a选自-OCH 3，-OCH 2 CH 3或-CCCH 3; 并且Z选自> C（H）-OH，> C（H）-O-烷基，> C（H）-O-氨基磺酸酯，其中烷基是包含1至10个的直链，支链和/或环状烃链 碳。
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公开(公告)号：US07498322B2
公开(公告)日：2009-03-03
申请号：US11077977
申请日：2005-03-11
CPC分类号： C07J1/00
摘要： Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: wherein Ra is selected from —OCH3, —OCH2CH3 or —CCCH3; and Z is selected from >C(H)—OH, >C(H)—O-alkyl, >C(H)—O-sulfamate, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.
摘要翻译： 通过施用有效量的下式化合物治疗哺乳动物疾病或特征在于不希望的血管发生的病症的组合物和方法：其中R a选自-OCH 3，-OCH 2 CH 3或-CCCH 3; 并且Z选自> C（H）-OH，> C（H）-O-烷基，> C（H）-O-氨基磺酸酯，其中烷基是包含1至10个的直链，支链和/或环状烃链 碳。
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公开(公告)号：US08158612B2
公开(公告)日：2012-04-17
申请号：US12341068
申请日：2008-12-22
IPC分类号： A61K31/56
CPC分类号： C07J1/00
摘要： Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: wherein Ra is selected from —OCH3, —OCH2CH3 or —CCCH3; and Z is selected from >C(H)—OH, >C(H)—O-alkyl, >C(H)—O-sulfamate, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.
摘要翻译： 通过施用有效量的下式化合物治疗哺乳动物疾病或特征在于不希望的血管发生的病症的组合物和方法：其中R a选自-OCH 3，-OCH 2 CH 3或-CCCH 3; 并且Z选自> C（H）-OH，> C（H）-O-烷基，> C（H）-O-氨基磺酸酯，其中烷基是包含1至10个的直链，支链和/或环状烃链 碳。
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公开(公告)号：US20080234243A1
公开(公告)日：2008-09-25
申请号：US12023710
申请日：2008-01-31
CPC分类号： A61K31/13
摘要： The compounds of the present invention can be used to inhibit formation of beta-amyloid protein. The present invention provides methods of preventing, delaying onset of, or treating diseases or conditions characterized or mediated by amyloidosis. In particular, the present invention is useful for preventing, delaying onset of, and treating Alzheimer's disease and related diseases causing dementia.
摘要翻译： 本发明的化合物可用于抑制β-淀粉样蛋白的形成。 本发明提供了预防，延缓发作或治疗由淀粉样变性特征或介导的疾病或病症的方法。 特别地，本发明可用于预防，延缓阿尔茨海默氏病和引起痴呆的相关疾病的发病和治疗。
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