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    Myeloid colony stimulating factor and uses thereof
    1.
    发明申请
    Myeloid colony stimulating factor and uses thereof 有权
    骨髓集落刺激因子及其用途

    公开(公告)号：US20060247201A1

    公开(公告)日：2006-11-02

    申请号：US11431181

    申请日：2006-05-09

    申请人： Gregory Frost ,  Per Borgstrom

    发明人： Gregory Frost ,  Per Borgstrom

    IPC分类号： A61K48/00 ,  A61K38/47

    CPC分类号： C12N9/2408 ,  A61K38/193 ,  A61K38/47 ,  A61K48/00

    摘要： The identification of the HYAL1 hyaluronidase enzyme as a human plasma-derived myeloid colony-stimulating factor (CSF), herein designated CSF5-hyaluronidase, its recombinant production and methods of use are described. This protein may be used for the treatment of myelosuppression as may occur after irradiation, chemotherapy or other diseases where an increase in leukocyte levels may be beneficial. For example, CSF5- may be used to enhance the immune response to viral infection or other diseases associated with immune suppression.

    摘要翻译： 描述了HYAL1透明质酸酶作为人血浆衍生的骨髓集落刺激因子（CSF），本文命名为CSF5-透明质酸酶，其重组生产和使用方法的鉴定。 该蛋白质可用于治疗照射，化学疗法或白细胞水平升高可能有益的其它疾病发生的骨髓抑制。 例如，CSF5-可用于增强对病毒感染或与免疫抑制相关的其它疾病的免疫应答。

    Inhibition of Antigen Presentation with Poorly Catabolized Polymers
    2.
    发明申请
    Inhibition of Antigen Presentation with Poorly Catabolized Polymers 审中-公开
    用低分解聚合物抑制抗原呈递

    公开(公告)号：US20100331279A1

    公开(公告)日：2010-12-30

    申请号：US12872620

    申请日：2010-08-31

    申请人： Gregory I. Frost ,  Per Borgstrom

    发明人： Gregory I. Frost ,  Per Borgstrom

    IPC分类号： A61K31/721 ,  C08B37/02 ,  A61P37/06

    CPC分类号： A61K39/00 ,  A61K31/715 ,  A61K31/721 ,  A61K39/001

    摘要： Methods to prevent the rejection of immunogenic tissues in an animal by administering a non-immunogenic, poorly catabolized molecule in an amount sufficient to inhibit an immune response are described herein. Also described are compositions that are useful for inhibiting immune responses in animals that are recipients of cellular transplants. For example, these methods and compositions can be used to prevent the rejection of xenografted and allografted tissues in an animal.

    摘要翻译： 本文描述了通过施用足以抑制免疫应答的量的非免疫原性差的分解代谢分子来防止动物中免疫原性组织排斥的方法。 还描述了可用于抑制作为细胞移植受体的动物中的免疫应答的组合物。 例如，这些方法和组合物可用于防止动物中异种移植和同种异体移植组织的排斥。

    Myeloid colony stimulating factor and uses thereof
    3.
    发明授权
    Myeloid colony stimulating factor and uses thereof 有权
    骨髓集落刺激因子及其用途

    公开(公告)号：US07718428B2

    公开(公告)日：2010-05-18

    申请号：US11431181

    申请日：2006-05-09

    申请人： Gregory I. Frost ,  Per Borgstrom

    发明人： Gregory I. Frost ,  Per Borgstrom

    IPC分类号： A01N1/02 ,  A61K38/00 ,  A61K38/43 ,  C07K14/00

    CPC分类号： C12N9/2408 ,  A61K38/193 ,  A61K38/47 ,  A61K48/00

    摘要： The identification of the HYAL1 hyaluronidase enzyme as a human plasma-derived myeloid colony-stimulating factor (CSF), designated CSF5-hyaluronidase, its recombinant production and methods of use are described. This protein may be used for the treatment of myelosuppression as may occur after irradiation, chemotherapy or other diseases where an increase in leukocyte levels may be beneficial. For example, CSF5-hyaluronidase may be used to enhance the immune response to viral infection or other diseases associated with immune suppression.

    摘要翻译： 描述了HYAL1透明质酸酶作为人血浆衍生的骨髓集落刺激因子（CSF），其命名为CSF5-透明质酸酶，其重组生产和使用方法的鉴定。 该蛋白质可用于治疗照射，化学疗法或白细胞水平升高可能有益的其它疾病发生的骨髓抑制。 例如，CSF5-透明质酸酶可用于增强对病毒感染或与免疫抑制相关的其它疾病的免疫应答。

    Inhibition of antigen presentation with poorly catabolized polymers
    4.
    发明授权
    Inhibition of antigen presentation with poorly catabolized polymers 失效
    用差的分解代谢聚合物抑制抗原呈递

    公开(公告)号：US07538097B2

    公开(公告)日：2009-05-26

    申请号：US10381855

    申请日：2001-09-25

    申请人： Gregory I. Frost ,  Per Borgstrom

    发明人： Gregory I. Frost ,  Per Borgstrom

    IPC分类号： A61K31/721 ,  A61K48/00

    CPC分类号： A61K39/00 ,  A61K31/715 ,  A61K31/721 ,  A61K39/001

    摘要： Methods to prevent the rejection of immunogenic tissues in an animal by administering a non-immunogenic, poorly catabolized molecule in an amount sufficient to inhibit an immune response are described herein. Also described are compositions that are useful for inhibiting immune responses in animals that are recipients of cellular transplants. For example, these methods and compositions can be used to prevent the rejection of xenografted and allografted tissues in an animal.

    摘要翻译： 本文描述了通过施用足以抑制免疫应答的量的非免疫原性差的分解代谢分子来防止动物中免疫原性组织排斥的方法。 还描述了可用于抑制作为细胞移植受体的动物中的免疫应答的组合物。 例如，这些方法和组合物可用于防止动物中异种移植和同种异体移植组织的排斥。

    Myeloid colony stimulating factor and uses thereof
    5.
    发明申请
    Myeloid colony stimulating factor and uses thereof 审中-公开
    骨髓集落刺激因子及其用途

    公开(公告)号：US20110212074A1

    公开(公告)日：2011-09-01

    申请号：US13068025

    申请日：2011-04-29

    申请人： Gregory I. Frost ,  Per Borgstrom

    发明人： Gregory I. Frost ,  Per Borgstrom

    IPC分类号： A61K38/47 ,  A61P37/00

    CPC分类号： C12N9/2408 ,  A61K38/193 ,  A61K38/47 ,  A61K48/00

    摘要： The identification of the HYAL 1 hyaluronidase enzyme as a human plasma-derived myeloid colony-stimulating factor (CSF), herein designated CSF5-hyaluronidase, its recombinant production and methods of use are described. This protein may be used for the treatment of myelosuppression as may occur after irradiation, chemotherapy or other diseases where an increase in leukocyte levels may be beneficial. For example, CSF5-may be used to enhance the immune response to viral infection or other diseases associated with immune suppression.

    摘要翻译： 描述了作为人血浆衍生的骨髓集落刺激因子（CSF）的HYAL 1透明质酸酶的鉴定，本文称为CSF5-透明质酸酶，其重组生产和使用方法。 该蛋白质可用于治疗照射，化学疗法或白细胞水平升高可能有益的其它疾病发生的骨髓抑制。 例如，CSF5可用于增强对病毒感染或与免疫抑制相关的其它疾病的免疫应答。

    Inhibition of antigen presentation with poorly catabolized polymers
    6.
    发明授权
    Inhibition of antigen presentation with poorly catabolized polymers 有权
    用差的分解代谢聚合物抑制抗原呈递

    公开(公告)号：US07786096B2

    公开(公告)日：2010-08-31

    申请号：US12463315

    申请日：2009-05-08

    申请人： Greogry I. Frost ,  Per Borgstrom

    发明人： Greogry I. Frost ,  Per Borgstrom

    IPC分类号： A61K31/721 ,  A61K38/00

    CPC分类号： A61K39/00 ,  A61K31/715 ,  A61K31/721 ,  A61K39/001

    摘要： Methods to prevent the rejection of immunogenic tissues in an animal by administering a non-immunogenic, poorly catabolized molecule in an amount sufficient to inhibit an immune response are described herein. Also described are compositions that are useful for inhibiting immune responses in animals that are recipients of cellular transplants. For example, these methods and compositions can be used to prevent the rejection of xenografted and allografted tissues in an animal.

    摘要翻译： 本文描述了通过施用足以抑制免疫应答的量的非免疫原性差的分解代谢分子来防止动物中免疫原性组织排斥的方法。 还描述了可用于抑制作为细胞移植受体的动物中的免疫应答的组合物。 例如，这些方法和组合物可用于防止动物中异种移植和同种异体移植组织的排斥。

    Inhibition of Antigen Presentation with Poorly Catabolized Polymers
    7.
    发明申请
    Inhibition of Antigen Presentation with Poorly Catabolized Polymers 有权
    用低分解聚合物抑制抗原呈递

    公开(公告)号：US20090215722A1

    公开(公告)日：2009-08-27

    申请号：US12463315

    申请日：2009-05-08

    申请人： Gregory I. Frost ,  Per Borgstrom

    发明人： Gregory I. Frost ,  Per Borgstrom

    IPC分类号： A61K31/721 ,  A61P37/06

    CPC分类号： A61K39/00 ,  A61K31/715 ,  A61K31/721 ,  A61K39/001

    摘要： Methods to prevent the rejection of immunogenic tissues in an animal by administering a non-immunogenic, poorly catabolized molecule in an amount sufficient to inhibit an immune response are described herein. Also described are compositions that are useful for inhibiting immune responses in animals that are recipients of cellular transplants. For example, these methods and compositions can be used to prevent the rejection of xenografted and allografted tissues in an animal.

    摘要翻译： 本文描述了通过施用足以抑制免疫应答的量的非免疫原性差的分解代谢分子来防止动物中免疫原性组织排斥的方法。 还描述了可用于抑制作为细胞移植受体的动物中的免疫应答的组合物。 例如，这些方法和组合物可用于防止动物中异种移植和同种异体移植组织的排斥。

    Myeloid Colony Stimulating Factor and Uses Thereof
    9.
    发明申请
    Myeloid Colony Stimulating Factor and Uses Thereof 审中-公开
    骨髓集落刺激因子及其用途

    公开(公告)号：US20100184845A1

    公开(公告)日：2010-07-22

    申请号：US12753046

    申请日：2010-04-01

    申请人： Gregory I. Frost ,  Per Borgstrom

    发明人： Gregory I. Frost ,  Per Borgstrom

    IPC分类号： A61K31/7088 ,  C12N9/26 ,  C07H21/04

    CPC分类号： C12N9/2408 ,  A61K38/193 ,  A61K38/47 ,  A61K48/00

    摘要： The identification of the HYAL1 hyaluronidase enzyme as a human plasma-derived myeloid colony-stimulating factor (CSF), herein designated CSF5-hyaluronidase, its recombinant production and methods of use are described. This protein may be used for the treatment of myelosuppression as may occur after irradiation, chemotherapy or other diseases where an increase in leukocyte levels may be beneficial. For example, CSF5- may be used to enhance the immune response to viral infection or other diseases associated with immune suppression.

    摘要翻译： 描述了HYAL1透明质酸酶作为人血浆衍生的骨髓集落刺激因子（CSF），本文命名为CSF5-透明质酸酶，其重组生产和使用方法的鉴定。 该蛋白质可用于治疗照射，化学疗法或白细胞水平升高可能有益的其它疾病发生的骨髓抑制。 例如，CSF5-可用于增强对病毒感染或与免疫抑制相关的其它疾病的免疫应答。