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1.发明授权Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject 有权用于神经调制的装置，方法和系统作为脊椎动物受试者中的疫苗佐剂公开(公告)号：US08364258B2
公开(公告)日：2013-01-29
申请号：US12802812
申请日：2010-06-14
申请人： Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： A61N1/18
CPC分类号： A61M37/00 , A61F7/00 , A61K39/39 , A61M37/0092 , A61N1/303 , A61N1/306 , A61N1/32 , A61N1/36121 , A61N2/00 , A61N2/002 , A61N2/006 , A61N2/02 , A61N5/0622
摘要： An apparatus for enhancing an immune response in a vertebrate subject is described. The apparatus includes providing at least one energy stimulus configured to modulate one or more nervous system components of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are provided in a combination and in a temporal sequence sufficient to enhance an immune response in the vertebrate subject.
摘要翻译： 描述了一种用于增强脊椎动物受试者的免疫应答的装置。 该装置包括提供至少一种能量刺激，其被配置成调节脊椎动物对象的一个或多个神经系统组分，以及向脊椎动物受试者施用一种或多种免疫原，其中所述至少一种能量刺激和所述一种或多种免疫原提供于 组合和时间序列，足以增强脊椎动物受试者的免疫应答。
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2.发明授权Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject 有权用于神经调制的装置，方法和系统作为脊椎动物受试者中的疫苗佐剂公开(公告)号：US08321012B2
公开(公告)日：2012-11-27
申请号：US12655195
申请日：2009-12-22
申请人： Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： A61N1/18
CPC分类号： A61M37/00 , A61F7/00 , A61K39/39 , A61M37/0092 , A61N1/303 , A61N1/306 , A61N1/32 , A61N1/36121 , A61N2/00 , A61N2/002 , A61N2/006 , A61N2/02 , A61N5/0622
摘要： A method for enhancing an immune response in a vertebrate subject is described. The method includes providing at least one energy stimulus configured to modulate one or more nervous system components of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are provided in a combination and in a temporal sequence sufficient to enhance an immune response in the vertebrate subject.
摘要翻译： 描述了一种增强脊椎动物受试者免疫应答的方法。 该方法包括提供至少一种能量刺激，其被配置成调节脊椎动物对象的一个或多个神经系统组分，以及向脊椎动物受试者施用一种或多种免疫原，其中所述至少一种能量刺激和所述一种或多种免疫原提供于 组合和时间序列，足以增强脊椎动物受试者的免疫应答。
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3.发明申请Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject 有权用于神经调制的装置，方法和系统，作为脊椎动物受试者中的疫苗佐剂公开(公告)号：US20110152748A1
公开(公告)日：2011-06-23
申请号：US12802812
申请日：2010-06-14
申请人： Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号： A61M37/00
CPC分类号： A61M37/00 , A61F7/00 , A61K39/39 , A61M37/0092 , A61N1/303 , A61N1/306 , A61N1/32 , A61N1/36121 , A61N2/00 , A61N2/002 , A61N2/006 , A61N2/02 , A61N5/0622
摘要： A method for enhancing an immune response in a vertebrate subject is described. The method includes providing at least one energy stimulus configured to modulate one or more nervous system components of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are provided in a combination and in a temporal sequence sufficient to enhance an immune response in the vertebrate subject.
摘要翻译： 描述了一种增强脊椎动物受试者免疫应答的方法。 该方法包括提供至少一种能量刺激，其被配置成调节脊椎动物对象的一个或多个神经系统组分，以及向脊椎动物受试者施用一种或多种免疫原，其中所述至少一种能量刺激和所述一种或多种免疫原提供于 组合和时间序列，足以增强脊椎动物受试者的免疫应答。
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4.发明申请Device, Method, and system for neural modulation as vaccine adjuvant in a vertebrate subject 有权用于神经调制的装置，方法和系统作为脊椎动物受试者中的疫苗佐剂公开(公告)号：US20110150924A1
公开(公告)日：2011-06-23
申请号：US12655195
申请日：2009-12-22
申请人： Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人： Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号： A61M37/00 , A61F7/00 , A61K39/39 , A61M37/0092 , A61N1/303 , A61N1/306 , A61N1/32 , A61N1/36121 , A61N2/00 , A61N2/002 , A61N2/006 , A61N2/02 , A61N5/0622
摘要： A method for enhancing an immune response in a vertebrate subject is described. The method includes providing at least one energy stimulus configured to modulate one or more nervous system components of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are provided in a combination and in a temporal sequence sufficient to enhance an immune response in the vertebrate subject.
摘要翻译： 描述了一种增强脊椎动物受试者免疫应答的方法。 该方法包括提供至少一种能量刺激，其被配置成调节脊椎动物对象的一个或多个神经系统组分，以及向脊椎动物受试者施用一种或多种免疫原，其中所述至少一种能量刺激和所述一种或多种免疫原提供于 组合和时间序列，足以增强脊椎动物受试者的免疫应答。
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公开(公告)号：US09358350B2
公开(公告)日：2016-06-07
申请号：US13568033
申请日：2012-08-06
申请人： Mahalaxmi Gita Bangera , Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, Jr.
发明人： Mahalaxmi Gita Bangera , Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, Jr.
CPC分类号： A61B34/10 , A61B17/3403 , A61B2017/3411 , A61B2034/108 , A61B2090/363 , A61M5/422 , A61M5/427 , A61M5/46 , A61M2205/13 , A61M2207/00 , A61M2210/0606 , B29C64/386 , B33Y50/02 , B33Y80/00 , G05B19/4099 , G05B2219/35134 , G05B2219/49007 , G06F17/5086
摘要： Systems and methods for wearable injection guides are described, which include: acquiring one or more digital images of a body region of an individual with at least one image capture device; creating a digitally rendered model of a wearable injection guide from the one or more digital images of the body region of the individual; adding one or more digitally rendered fiducials indicative of at least one treatment parameter to the digitally rendered model of the wearable injection guide; and forming the wearable injection guide from the digitally rendered model of the wearable injection guide, the formed wearable injection guide including one or more fiducials corresponding to the one or more digitally rendered fiducials on the digitally rendered model of the wearable injection guide.
摘要翻译： 描述了可穿戴式注射引导件的系统和方法，其包括：用至少一个图像捕获装置获取个体的身体区域的一个或多个数字图像; 从个体的身体区域的一个或多个数字图像创建可戴式注射引导件的数字渲染模型; 将指示至少一个治疗参数的一个或多个数字呈现的基准添加到所述可佩戴注射引导件的数字渲染模型; 以及从所述可穿戴式注射导向器的数字渲染模型形成所述可穿戴式注射导向器，所述可穿戴式注射引导件包括与所述可穿戴式注射导向器的数字渲染模型上的所述一个或多个数字呈现的基准相对应的一个或多个基准。
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公开(公告)号：US20140039451A1
公开(公告)日：2014-02-06
申请号：US13567921
申请日：2012-08-06
申请人： Mahalaxmi Gita Bangera , Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, JR.
发明人： Mahalaxmi Gita Bangera , Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, JR.
IPC分类号： A61M5/42
CPC分类号： A61B34/10 , A61B17/3403 , A61B2017/3411 , A61B2034/108 , A61B2090/363 , A61M5/422 , A61M5/427 , A61M5/46 , A61M2205/13 , A61M2207/00 , A61M2210/0606 , B29C64/386 , B33Y50/02 , B33Y80/00 , G05B19/4099 , G05B2219/35134 , G05B2219/49007 , G06F17/5086
摘要： Wearable injection guides and manufacture and use thereof are described, which include: a rigid material formed to substantially conform in shape to a topography of a body region of an individual, the rigid material substantially impenetrable to an injection needle, and the rigid material including one or more injection needle access regions arranged in a treatment pattern.
摘要翻译： 描述了可穿戴的注射引导件及其制造和使用，其包括：刚性材料，形成为基本上符合个体的身体区域的形状，基本上不能穿透到注射针的刚性材料，并且刚性材料包括一个 或更多的注射针入口区域以治疗图案排列。
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公开(公告)号：US09205204B2
公开(公告)日：2015-12-08
申请号：US13567995
申请日：2012-08-06
申请人： Mahalaxmi Gita Bangera , Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, Jr.
发明人： Mahalaxmi Gita Bangera , Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, Jr.
CPC分类号： A61B34/10 , A61B17/3403 , A61B2017/3411 , A61B2034/108 , A61B2090/363 , A61M5/422 , A61M5/427 , A61M5/46 , A61M2205/13 , A61M2207/00 , A61M2210/0606 , B29C64/386 , B33Y50/02 , B33Y80/00 , G05B19/4099 , G05B2219/35134 , G05B2219/49007 , G06F17/5086
摘要： Wearable injection guides and manufacture and use thereof are described, which include: a rigid needle-penetrable material having an inner surface and an outer surface, the inner surface having form-fitting contours substantially conforming to a topography of a body region of an individual and the outer surface including one or more fiducials indication of at least one treatment parameter.
摘要翻译： 描述了可穿戴式注射引导件及其制造和使用，其包括：具有内表面和外表面的刚性可针穿透材料，内表面具有基本上符合个人身体区域的形貌的形状配合轮廓， 所述外表面包括至少一个治疗参数的一个或多个基准指示。
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公开(公告)号：US09199044B2
公开(公告)日：2015-12-01
申请号：US13567921
申请日：2012-08-06
申请人： Mahalaxmi Gita Bangera , Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, Jr.
发明人： Mahalaxmi Gita Bangera , Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, Jr.
CPC分类号： A61B34/10 , A61B17/3403 , A61B2017/3411 , A61B2034/108 , A61B2090/363 , A61M5/422 , A61M5/427 , A61M5/46 , A61M2205/13 , A61M2207/00 , A61M2210/0606 , B29C64/386 , B33Y50/02 , B33Y80/00 , G05B19/4099 , G05B2219/35134 , G05B2219/49007 , G06F17/5086
摘要： Wearable injection guides and manufacture and use thereof are described, which include: a rigid material formed to substantially conform in shape to a topography of a body region of an individual, the rigid material substantially impenetrable to an injection needle, and the rigid material including one or more injection needle access regions arranged in a treatment pattern.
摘要翻译： 描述了可穿戴的注射引导件及其制造和使用，其包括：刚性材料，形成为基本上符合个体的身体区域的形状，刚性材料基本上不可渗透到注射针，并且刚性材料包括一个 或更多的注射针入口区域以治疗图案排列。
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公开(公告)号：US20140039658A1
公开(公告)日：2014-02-06
申请号：US13568033
申请日：2012-08-06
申请人： Mahalaxmi Gita Bangera , Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, JR.
发明人： Mahalaxmi Gita Bangera , Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, JR.
IPC分类号： G06F17/50
CPC分类号： A61B34/10 , A61B17/3403 , A61B2017/3411 , A61B2034/108 , A61B2090/363 , A61M5/422 , A61M5/427 , A61M5/46 , A61M2205/13 , A61M2207/00 , A61M2210/0606 , B29C64/386 , B33Y50/02 , B33Y80/00 , G05B19/4099 , G05B2219/35134 , G05B2219/49007 , G06F17/5086
摘要： Systems and methods for wearable injection guides are described, which include: acquiring one or more digital images of a body region of an individual with at least one image capture device; creating a digitally rendered model of a wearable injection guide from the one or more digital images of the body region of the individual; adding one or more digitally rendered fiducials indicative of at least one treatment parameter to the digitally rendered model of the wearable injection guide; and forming the wearable injection guide from the digitally rendered model of the wearable injection guide, the formed wearable injection guide including one or more fiducials corresponding to the one or more digitally rendered fiducials on the digitally rendered model of the wearable injection guide.
摘要翻译： 描述了可穿戴式注射引导件的系统和方法，其包括：用至少一个图像捕获装置获取个体的身体区域的一个或多个数字图像; 从个体的身体区域的一个或多个数字图像创建可戴式注射引导件的数字渲染模型; 将指示至少一个治疗参数的一个或多个数字呈现的基准添加到所述可佩戴注射引导件的数字渲染模型; 以及从所述可穿戴式注射导向器的数字渲染模型形成所述可穿戴式注射导向器，所述可穿戴式注射引导件包括与所述可穿戴注射导向器的数字渲染模型上的所述一个或多个数字呈现的基准相对应的一个或多个基准。
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公开(公告)号：US20140039452A1
公开(公告)日：2014-02-06
申请号：US13567995
申请日：2012-08-06
申请人： Mahalaxmi Gita Bangera , Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, JR.
发明人： Mahalaxmi Gita Bangera , Edward S. Boyden , Hon Wah Chin , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Robert Langer , Eric C. Leuthardt , Stephen L. Malaska , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Sharon L. Wolda , Lowell L. Wood, JR.
IPC分类号： A61M5/42
CPC分类号： A61B34/10 , A61B17/3403 , A61B2017/3411 , A61B2034/108 , A61B2090/363 , A61M5/422 , A61M5/427 , A61M5/46 , A61M2205/13 , A61M2207/00 , A61M2210/0606 , B29C64/386 , B33Y50/02 , B33Y80/00 , G05B19/4099 , G05B2219/35134 , G05B2219/49007 , G06F17/5086
摘要： Wearable injection guides and manufacture and use thereof are described, which include: a rigid needle-penetrable material having an inner surface and an outer surface, the inner surface having form-fitting contours substantially conforming to a topography of a body region of an individual and the outer surface including one or more fiducials indication of at least one treatment parameter.
摘要翻译： 描述了可穿戴式注射引导件及其制造和使用，其包括：具有内表面和外表面的刚性可穿透针材料，内表面具有基本上符合个人身体区域的形貌的形状配合轮廓， 所述外表面包括至少一个治疗参数的一个或多个基准指示。
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