公开(公告)号：US20210171596A1

公开(公告)日：2021-06-10

申请号：US16798247

申请日：2020-02-21

申请人： Gregory Moore ,  Rajat Varma ,  Yoon Kyung Kim ,  Rumana Rashid ,  Eric W. Chang ,  Alex Nisthal ,  Juan Diaz ,  Matthew Bernett ,  Michael Hedvat

发明人： Gregory Moore ,  Rajat Varma ,  Yoon Kyung Kim ,  Rumana Rashid ,  Eric W. Chang ,  Alex Nisthal ,  Juan Diaz ,  Matthew Bernett ,  Michael Hedvat

IPC分类号： C07K14/54

摘要： The present invention provides untargeted and targeted IL-10-Fc fusion proteins, compositions and methods of use thereof. The targeted IL-10-Fc fusion proteins includes those that bind PD-1, TIGIT, CD8 and NKG2D.

公开(公告)号：US20070104714A1

公开(公告)日：2007-05-10

申请号：US10568669

申请日：2004-08-27

申请人： David Agus ,  Anjali Jain ,  Michael Hedvat

发明人： David Agus ,  Anjali Jain ,  Michael Hedvat

IPC分类号： A61K39/395 ,  A61K31/60 ,  A61K31/405 ,  A61K31/192

CPC分类号： A61K45/06 ,  A61K31/19 ,  A61K31/192 ,  A61K31/405 ,  A61K31/407 ,  A61K31/47 ,  A61K31/60 ,  A61K39/395 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/3069 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/76 ,  A61K2300/00

摘要： Described herein are methods of using a NSAID and a HER-kinase axis inhibitor in the treatment of various conditions including cancer, and especially prostate, breast, lung, ovarian, brain and colon cancers, through regulation of PPARγ activity. In various embodiments, the NSAID and HER-kinase axis inhibitor may be included in a composition that is useful for the treatment of conditions in a mammal. Also described is a kit including a NSAID and a HER-kinase axis inhibitor along with instructions for their use in treating and preventing disease conditions, such as cancer.

摘要翻译： 本文描述的是通过调节PPARγ活性来使用NSAID和HER-激酶轴抑制剂治疗各种疾病，包括癌症，特别是前列腺，乳腺，肺癌，卵巢癌，脑癌和结肠癌的方法。 在各种实施方案中，NSAID和HER-激酶轴抑制剂可以包含在可用于治疗哺乳动物中的病症的组合物中。 还描述了一种试剂盒，其包括NSAID和HER-激酶轴抑制剂以及其用于治疗和预防疾病状况如癌症的说明书。