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公开(公告)号：US5501855A
公开(公告)日：1996-03-26
申请号：US115867
申请日：1993-09-02
IPC分类号： A61K31/12 , A61K31/335 , A61K31/34 , A61K36/58 , A61K35/78
CPC分类号： A61K36/58 , Y10S514/841
摘要： An alternate approach to vasectomy for long term male contraception following a single intra-vas.application of a traditional plant (Azadirachta indica) product having immunomodulatory properties is described. The intra-vas administration of neem oil to male rats resulted in a block of spermatogenesis without affecting the testosterone production; the seminiferous tubules, although reduced in diameter, appeared normal and contained mostly early spermatogenic cells. No antisperm antibody could be detected in the serum. Unilateral administration of neem oil in the vas resulted in a significant reduction of testicular size and spermatogenic block only on the side of application; the draining lymph node cells of the treated side also showed enhanced proliferative response to in vitro mitogen challenge. These results indicate that intra-vas application of neem oil is effective in blocking fertility in male mammals after a single injection.
摘要翻译： 描述了具有免疫调节特性的传统植物（Azadirachta indica）产品的单次输注之后的长期男性避孕药的输精管切除术的替代方法。 向男性大鼠口内给予楝树油导致精子发生障碍，而不会影响睾酮的产生; 尽管直径减小，生精小管似乎正常，主要是早期的生精细胞。 血清中不能检测到抗精子抗体。 血管内单纯给予楝树油导致睾丸大小和精子发生阻滞的显着减少仅在应用方面; 处理侧的引流淋巴结细胞也显示增强的体外促分裂原分子攻击的增殖反应。 这些结果表明，在单次注射后，楝树油的血管内应用有效阻断雄性哺乳动物的生育力。
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2.发明授权Method for blocking endothelial cell-leukocyte attachment by inhibiting expression of adhesion molecules on the vascular endothelium for therapeutic applications 失效通过抑制血管内皮上的粘附分子表达来治疗应用来阻断内皮细胞 - 白细胞附着的方法公开(公告)号：US06395772B1
公开(公告)日：2002-05-28
申请号：US09304415
申请日：1999-05-03
申请人： Shakti N. Upadhyay , Suman Dhawan
发明人： Shakti N. Upadhyay , Suman Dhawan
IPC分类号： A61K31335
CPC分类号： C07D491/04 , A61K31/4745
摘要： A method for blocking the attachment of leukocytes to endothelial cells/lining of the blood vessels using a plant derived protoberberine alkaloid, berberine or its pharmaceutically acceptable salts. This prevents tissue damage to the surrounding tissue. The method also can be used to prevent and/or treat clinical manifestations that involve endothelial cell-leukocyte attachment, for example septic shock, arthritis, psoriasis, multiple sclerosis, allergic asthma, metastatic melanoma and graft rejection.
摘要翻译： 一种使用植物衍生的原生青霉素生物碱，小檗碱或其药学上可接受的盐来阻断白细胞与内皮细胞/血管内衬的附着的方法。 这可防止对周围组织的组织损伤。 该方法还可用于预防和/或治疗涉及内皮细胞 - 白细胞附着的临床表现，例如脓毒性休克，关节炎，牛皮癣，多发性硬化，过敏性哮喘，转移性黑素瘤和移植排斥反应。
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3.发明授权Method for suppressing allogenic immune response or prevention/treatment of graft vs. host disease or graft rejection 失效抑制同种异体免疫反应或预防/治疗移植物抗宿主病或移植物排斥的方法公开(公告)号：US06245781B1
公开(公告)日：2001-06-12
申请号：US08789464
申请日：1997-01-27
IPC分类号： A01N4340
CPC分类号： C07D491/04 , A61K31/4745
摘要： Berberine or pharmaceutically acceptable salts thereof either alone or in combination with cyclosporin can be used to treat or prevent graft vs. host disease. Berberine or pharmaceutically acceptable salts thereof can also be used to treat or prevent septic shock syndrome.
摘要翻译： 单独或与环孢菌素组合的小檗碱或其药学上可接受的盐可用于治疗或预防移植物抗宿主病。 小檗碱或其药学上可接受的盐也可用于治疗或预防败血性休克综合征。
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公开(公告)号：US06291483B1
公开(公告)日：2001-09-18
申请号：US09022299
申请日：1998-02-11
申请人： Shakti N. Upadhyay , Suman Dhawan
发明人： Shakti N. Upadhyay , Suman Dhawan
IPC分类号： A61K31445
CPC分类号： C07D491/04 , A61K31/4745
摘要： Berberine or pharmaceutically acceptable salts thereof either alone or in combination with cyclosporin can be used to treat or prevent graft vs. host disease. Berberine or pharmaceutically acceptable salts thereof can also be used to treat or prevent septic shock syndrome.
摘要翻译： 单独或与环孢菌素组合的小檗碱或其药学上可接受的盐可用于治疗或预防移植物抗宿主病。 小檗碱或其药学上可接受的盐也可用于治疗或预防败血性休克综合征。
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