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公开(公告)号：US5762931A
公开(公告)日：1998-06-09
申请号：US295774
申请日：1994-11-07
CPC分类号： C07K16/26 , A61K38/00 , C07K2317/73
摘要： This invention relates to a method of combatting cancer which cancer releases chorionic gonadotropin or a subunit thereof present in a mammal which method comprises administering to said animal an anti-cancer effective amount of a birth-control vaccine or an antibody to said chorionic gonadotropin or subunit thereof. Birth-control vaccines which are polyvalent vaccines and birth-control vaccines which employ recombinant organisms incorporating sequences coding for reproductive hormones are of particular interest as well as polyclonal and monoclonal antibodies to the chorionic gonadotropin.
摘要翻译： PCT No.PCT / US92 / 11333 Sec。 371日期：1994年11月7日 102（e）日期1994年11月7日PCT提交1992年12月31日PCT公布。 公开号WO94 / 15633 日期：1994年7月21日本发明涉及一种抗癌药物的方法，所述方法包括向所述动物施用抗癌有效量的避孕疫苗或抗体， 所述绒毛膜促性腺激素或其亚单位。 作为多价疫苗的避孕疫苗和使用含有编码生殖激素的序列的重组生物的避孕疫苗是特别有意义的，以及对绒毛膜促性腺激素的多克隆和单克隆抗体。
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公开(公告)号：US5501855A
公开(公告)日：1996-03-26
申请号：US115867
申请日：1993-09-02
IPC分类号： A61K31/12 , A61K31/335 , A61K31/34 , A61K36/58 , A61K35/78
CPC分类号： A61K36/58 , Y10S514/841
摘要： An alternate approach to vasectomy for long term male contraception following a single intra-vas.application of a traditional plant (Azadirachta indica) product having immunomodulatory properties is described. The intra-vas administration of neem oil to male rats resulted in a block of spermatogenesis without affecting the testosterone production; the seminiferous tubules, although reduced in diameter, appeared normal and contained mostly early spermatogenic cells. No antisperm antibody could be detected in the serum. Unilateral administration of neem oil in the vas resulted in a significant reduction of testicular size and spermatogenic block only on the side of application; the draining lymph node cells of the treated side also showed enhanced proliferative response to in vitro mitogen challenge. These results indicate that intra-vas application of neem oil is effective in blocking fertility in male mammals after a single injection.
摘要翻译： 描述了具有免疫调节特性的传统植物（Azadirachta indica）产品的单次输注之后的长期男性避孕药的输精管切除术的替代方法。 向男性大鼠口内给予楝树油导致精子发生障碍，而不会影响睾酮的产生; 尽管直径减小，生精小管似乎正常，主要是早期的生精细胞。 血清中不能检测到抗精子抗体。 血管内单纯给予楝树油导致睾丸大小和精子发生阻滞的显着减少仅在应用方面; 处理侧的引流淋巴结细胞也显示增强的体外促分裂原分子攻击的增殖反应。 这些结果表明，在单次注射后，楝树油的血管内应用有效阻断雄性哺乳动物的生育力。
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公开(公告)号：US4161519A
公开(公告)日：1979-07-17
申请号：US789455
申请日：1977-04-21
申请人： Gursaran P. Talwar
发明人： Gursaran P. Talwar
CPC分类号： A61K39/0006 , A61K2039/6037 , Y10S424/811 , Y10S436/814 , Y10S436/818 , Y10S530/807
摘要： A vaccine comprising a conjugate of an antigenic carrier with beta sub-unit of human chorionic gonadotropin, or derivatives or fragments thereof, purified by procedures which minimize cross-reactivity with LH, such as immunosorption with heterologous LH antiserum prior to conjugation, and a process for making the vaccine. In addition, a process for preventing pregnancy using said vaccine is described.
摘要翻译： 包含抗原载体与人绒毛膜促性腺激素的β亚单位或其衍生物或片段的缀合物的疫苗，其通过使与LH的交叉反应性最小化的方法纯化，例如在缀合之前与异源LH抗血清的免疫吸附，以及过程 用于制作疫苗。 另外，描述了使用所述疫苗预防怀孕的过程。
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公开(公告)号：US5196197A
公开(公告)日：1993-03-23
申请号：US574307
申请日：1990-08-28
CPC分类号： A61K36/58 , A61K36/77 , Y10S424/12 , Y10S424/14
摘要： There is provided a means for reversible fertility control for prevention of pregnancy in female mammals for several months through the use of neem oil or its components, applied locally to the uterus. There is also provided a spermicidal composition containing neem oil or its components in combination with reetha extract as a vaginal cream.
摘要翻译： 通过使用局部施用于子宫的楝树油或其组分，为哺乳动物哺乳动物预防妊娠数月提供了可逆的生育调控手段。 还提供了含有楝树油或其组分与雷珠精油作为阴道霜剂组合的杀精剂组合物。
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公开(公告)号：US4191746A
公开(公告)日：1980-03-04
申请号：US18624
申请日：1979-03-08
申请人： Gursaran P. Talwar
发明人： Gursaran P. Talwar
CPC分类号： A61K39/04 , A61K35/74 , Y10S424/824 , Y10S424/828
摘要： Aspermatogenesis is achieved in mammalian species without disturbance of libido and hormone level by intratesticular injection of Bacillus of Calmette and Guerin. The procedure is applicable to a wide variety of mammalian species.
摘要翻译： 通过腔内注射卡尔梅特和桂皮芽孢杆菌，在哺乳动物物种中实现不发生性欲和激素水平的异常发生。 该程序适用于各种哺乳动物物种。
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公开(公告)号：US4780312A
公开(公告)日：1988-10-25
申请号：US870502
申请日：1986-06-04
申请人： Gursaran P. Talwar
发明人： Gursaran P. Talwar
CPC分类号： C07K14/59 , A61K39/00 , Y10S424/811
摘要： A polyvalent vaccine for control of fertility is disclosed, the vaccine having a multiplicity of determinant antigens in the reproductive system of mammals, the antigens being linked to at least one carrier. The precise manner of linkage can differ, and preferably more than one carrier is present thereby increasing antibody response particularly in those subjects who are poor responders when a single carrier only is used. The new vaccine thus has a multi-valent capability against the reproductive system and also preferably the capability of producing immunoprophylactic benefit against more than one health hazard.
摘要翻译： 公开了用于控制生殖力的多价疫苗，该疫苗在哺乳动物的生殖系统中具有多种决定簇抗原，该抗原与至少一种载体连接。 连接的精确方式可以不同，并且优选多于一种载体存在，从而增加抗体应答，特别是当仅使用单载体时那些不良反应者的受试者。 因此，新疫苗具有针对生殖系统的多价能力，并且还优选具有针对多于一种健康危害的免疫预防效果的能力。
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公开(公告)号：US4271069A
公开(公告)日：1981-06-02
申请号：US946098
申请日：1978-09-26
IPC分类号： A61K39/00 , C07K14/59 , C07K16/26 , C07C103/52
摘要： Method of purifying the beta sub-unit of chorionic gondotropin which includes contacting a preparation of the beta sub-unit of chorionic gonadotropin with an insolubilized anti alpha sub-unit of chorionic gondotropin serum and the highly purified beta sub-unit of chorionic gonadotropin obtained by this method.
摘要翻译： 纯化绒毛膜促性腺激素的β亚单位的方法，其包括将绒毛膜促性腺激素的β亚单位的制剂与绒毛膜促性腺素血清的不溶性抗α亚单位和绒毛膜促性腺激素的高度纯化的β亚单位接触，所述β亚单位通过 这种方法。
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