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1.发明授权Systems for producing multilayered particles, fibers and sprays and methods for administering the same 失效用于生产多层颗粒，纤维和喷雾剂的系统及其施用方法公开(公告)号：US08297959B2
公开(公告)日：2012-10-30
申请号：US11743560
申请日：2007-05-02
申请人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz , David Vu , Luis Nunez
发明人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz , David Vu , Luis Nunez
CPC分类号： A61K9/5146 , A61K9/5094 , A61K9/5115 , A61K9/5192 , A61K47/551 , A61K47/642 , A61K47/6425 , A61K47/6849 , A61K47/6925 , A61K49/0043 , A61K49/0047 , A61K49/0056 , A61K49/0065 , A61K49/0093 , A61K49/1878 , A61K51/1244 , B01J13/04 , B05B5/0255 , B05B7/061 , B82Y5/00
摘要： Capsules and particles with at least one encapsulated and/or entrapped agent, such as therapeutic agent, imaging agents, and other constituents may be produced by electrohydrodynamic processes. More particularly, the agent encapsulated in a vehicle, capsule, particle, vector, or carrier may maximize treatment and/or imaging of malignant cancers while minimizing the adverse effects of treatment and/or imaging.
摘要翻译： 具有至少一种包封和/或包埋的试剂（例如治疗剂，成像剂和其它成分）的胶囊和颗粒可以通过电动力学方法制备。 更具体地，封装在载体，胶囊，颗粒，载体或载体中的试剂可以最大限度地减少治疗和/或成像的不利影响，从而最大化恶性癌症的治疗和/或成像。
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2.发明申请SYSTEMS FOR PRODUCING MULTILAYERED PARTICLES, FIBERS AND SPRAYS AND METHODS FOR ADMINISTERING THE SAME 失效用于生产多层颗粒，纤维和喷雾的系统及其管理方法公开(公告)号：US20070296099A1
公开(公告)日：2007-12-27
申请号：US11743560
申请日：2007-05-02
申请人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz , David Vu , Luis Nunez
发明人： Gustavo Larsen , Ruben Spretz , Raffet Velarde-Ortiz , David Vu , Luis Nunez
IPC分类号： A61K9/00
CPC分类号： A61K9/5146 , A61K9/5094 , A61K9/5115 , A61K9/5192 , A61K47/551 , A61K47/642 , A61K47/6425 , A61K47/6849 , A61K47/6925 , A61K49/0043 , A61K49/0047 , A61K49/0056 , A61K49/0065 , A61K49/0093 , A61K49/1878 , A61K51/1244 , B01J13/04 , B05B5/0255 , B05B7/061 , B82Y5/00
摘要： Capsules and particles with at least one encapsulated and/or entrapped agent, such as therapeutic agent, imaging agents, and other constituents may be produced by electrohydrodynamic processes. More particularly, the agent encapsulated in a vehicle, capsule, particle, vector, or carrier may maximize treatment and/or imaging of malignant cancers while minimizing the adverse effects of treatment and/or imaging.
摘要翻译： 具有至少一种包封和/或包埋的试剂（例如治疗剂，成像剂和其它成分）的胶囊和颗粒可以通过电动力学方法制备。 更具体地，封装在载体，胶囊，颗粒，载体或载体中的试剂可以最大限度地减少治疗和/或成像的不利影响，从而最大化恶性癌症的治疗和/或成像。
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公开(公告)号：US08257778B2
公开(公告)日：2012-09-04
申请号：US13414949
申请日：2012-03-08
IPC分类号： A61F13/02
CPC分类号： A61K38/363 , A61K38/4833 , A61K38/484 , A61L15/32 , A61L2400/04 , D01D5/0061 , D01D5/0092 , D01D5/18 , D01D10/00 , D01F1/10
摘要： A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.
摘要翻译： 通过制造最大限度地暴露每单位重量活性成分的表面积的纤维作为帮助凝块形成过程的手段并且作为使活性成分的浪费最小化的手段来制造坚固和柔韧的纤维止血敷料的方法。 该方法使用旋转物体来分离其中心附加的液体生物相容性纤维前体。 形成的纤维然后沉积在与旋转物体一定距离处的收集器上，在收集器上产生纤维层。 在旋转盘和收集器之间保持电位差。 然后，将液体促凝物质引入旋转盘的中心，使其旋转旋转盘并涂覆纤维。
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公开(公告)号：US20120171355A1
公开(公告)日：2012-07-05
申请号：US13414949
申请日：2012-03-08
IPC分类号： A61F13/02
CPC分类号： A61K38/363 , A61K38/4833 , A61K38/484 , A61L15/32 , A61L2400/04 , D01D5/0061 , D01D5/0092 , D01D5/18 , D01D10/00 , D01F1/10
摘要： A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.
摘要翻译： 通过制造最大限度地暴露每单位重量活性成分的表面积的纤维作为帮助凝块形成过程的手段并且作为使活性成分的浪费最小化的手段来制造坚固和柔韧的纤维止血敷料的方法。 该方法使用旋转物体来分离其中心附加的液体生物相容性纤维前体。 形成的纤维然后沉积在与旋转物体一定距离处的收集器上，在收集器上产生纤维层。 在旋转盘和收集器之间保持电位差。 然后，将液体促凝物质引入旋转盘的中心，使其旋转旋转盘并涂覆纤维。
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公开(公告)号：US20090136651A1
公开(公告)日：2009-05-28
申请号：US12281588
申请日：2007-01-13
IPC分类号： B05D3/12
CPC分类号： A61K38/363 , A61K38/4833 , A61K38/484 , A61L15/32 , A61L2400/04 , D01D5/0061 , D01D5/0092 , D01D5/18 , D01D10/00 , D01F1/10
摘要： A method of manufacturing a sturdy and pliable fibrous hemostatic dressing by making fibers that maximally expose surface area per unit weight of active ingredients as a means for aiding in the clot forming process and as a means of minimizing waste of active ingredients. The method uses a rotating object to spin off a liquid biocompatible fiber precursor, which is added at its center. Fibers formed then deposit on a collector located at a distance from the rotating object creating a fiber layer on the collector. An electrical potential difference is maintained between the rotating disk and the collector. Then, a liquid procoagulation species is introduced at the center of the rotating disk such that it spins off the rotating disk and coats the fibers.
摘要翻译： 通过制造最大限度地暴露每单位重量活性成分的表面积的纤维作为帮助凝块形成过程的手段并且作为使活性成分的浪费最小化的手段来制造坚固和柔韧的纤维止血敷料的方法。 该方法使用旋转物体来分离其中心附加的液体生物相容性纤维前体。 形成的纤维然后沉积在与旋转物体一定距离处的收集器上，在收集器上产生纤维层。 在旋转盘和收集器之间保持电位差。 然后，将液体促凝物质引入旋转盘的中心，使其旋转旋转盘并涂覆纤维。
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