公开(公告)号：US10329326B2

公开(公告)日：2019-06-25

申请号：US15263028

申请日：2016-09-12

申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. ,  INTEZYNE TECHNOLOGIES INC. ,  ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

发明人： Robert J. Gillies ,  David L. Morse ,  Natalie M. Barkey ,  Kevin N. Sill ,  Josef Vagner ,  Narges K. Tafreshi ,  Jonathan L. Sessler ,  Christian Preihs ,  Victor J. Hruby

IPC分类号： A61K38/00 ,  C07K5/117 ,  C07K14/68 ,  A61K49/00 ,  A61K49/10 ,  A61K49/18 ,  C07K7/08 ,  C07K14/72 ,  A61K47/64 ,  A61K47/69 ,  A61K38/34

摘要： The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.

公开(公告)号：US11230568B2

公开(公告)日：2022-01-25

申请号：US16450382

申请日：2019-06-24

申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. ,  INTEZYNE TECHNOLOGIES INC. ,  ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

发明人： Robert J. Gillies ,  David L. Morse ,  Natalie M. Barkey ,  Kevin N. Sill ,  Josef Vagner ,  Narges K. Tafreshi ,  Jonathan L. Sessler ,  Christian Preihs ,  Victor J. Hruby

IPC分类号： A61K38/00 ,  C07K5/117 ,  A61K49/10 ,  C07K14/72 ,  A61K47/64 ,  A61K47/69 ,  C07K14/68 ,  A61K49/00 ,  A61K49/18 ,  C07K7/08 ,  A61K38/34

摘要： The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.