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公开(公告)号：US10329326B2
公开(公告)日：2019-06-25
申请号：US15263028
申请日：2016-09-12
申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , INTEZYNE TECHNOLOGIES INC. , ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
发明人： Robert J. Gillies , David L. Morse , Natalie M. Barkey , Kevin N. Sill , Josef Vagner , Narges K. Tafreshi , Jonathan L. Sessler , Christian Preihs , Victor J. Hruby
IPC分类号： A61K38/00 , C07K5/117 , C07K14/68 , A61K49/00 , A61K49/10 , A61K49/18 , C07K7/08 , C07K14/72 , A61K47/64 , A61K47/69 , A61K38/34
摘要： The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.
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公开(公告)号：US11230568B2
公开(公告)日：2022-01-25
申请号：US16450382
申请日：2019-06-24
申请人： H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. , INTEZYNE TECHNOLOGIES INC. , ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
发明人： Robert J. Gillies , David L. Morse , Natalie M. Barkey , Kevin N. Sill , Josef Vagner , Narges K. Tafreshi , Jonathan L. Sessler , Christian Preihs , Victor J. Hruby
IPC分类号： A61K38/00 , C07K5/117 , A61K49/10 , C07K14/72 , A61K47/64 , A61K47/69 , C07K14/68 , A61K49/00 , A61K49/18 , C07K7/08 , A61K38/34
摘要： The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.
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公开(公告)号：US10143689B2
公开(公告)日：2018-12-04
申请号：US15892216
申请日：2018-02-08
发明人： Kevin N. Sill , Adam Carie
摘要： The present invention provides SN-38 compositions for treating cancer.
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4.发明授权公开(公告)号：US08629186B2
公开(公告)日：2014-01-14
申请号：US13951381
申请日：2013-07-25
发明人： Kevin N. Sill , Habib Skaff , Jonathan Rios-Doris
CPC分类号： A61K47/42 , A61K9/1075 , A61K31/35
摘要： The present invention provides micelles having an anthracycline encapsulated therein, the micelles comprising a multiblock copolymer. The invention further provides methods of preparing and using said micelles, and compositions thereof.
摘要翻译： 本发明提供了胶囊中包含蒽环类胶束，胶束包含多嵌段共聚物。 本发明还提供了制备和使用所述胶束的方法及其组合物。
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公开(公告)号：US10857147B2
公开(公告)日：2020-12-08
申请号：US16195264
申请日：2018-11-19
发明人： Kevin N. Sill , Adam Carie
摘要： The present invention provides SN-38 compositions for treating cancer.
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公开(公告)号：US20190321353A1
公开(公告)日：2019-10-24
申请号：US16195264
申请日：2018-11-19
发明人： Kevin N. Sill , Adam Carie
摘要： The present invention provides SN-38 compositions for treating cancer.
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公开(公告)号：US20180228796A1
公开(公告)日：2018-08-16
申请号：US15892216
申请日：2018-02-08
发明人： Kevin N. Sill , Adam Carie
CPC分类号： A61K31/4745 , A61K9/1075 , A61K47/02 , A61K47/26 , A61K47/34 , A61P35/00
摘要： The present invention provides SN-38 compositions for treating cancer.
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8.发明申请HYBRID BLOCK COPOLYMER MICELLES WITH MIXED STEREOCHEMISTRY FOR ENCAPSULATION OF HYDROPHOBIC AGENTS 审中-公开具有混合立体化学的混合嵌段共聚物微胶囊用于渗透代谢物公开(公告)号：US20150232616A1
公开(公告)日：2015-08-20
申请号：US14615383
申请日：2015-02-05
发明人： Kevin N. Sill , Habib Skaff , Kurt Breitenkamp
IPC分类号： C08G69/08
CPC分类号： C08G69/08 , A61K9/1075 , A61K47/34 , C08G65/2627 , C08G65/325 , C08G65/33341 , C08G73/028 , C08G2261/126 , C08J3/03 , C08J2377/04 , C08L2203/02 , Y10S930/29 , Y10S977/773 , Y10S977/906
摘要： The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.
摘要翻译： 本发明涉及聚合物化学领域，更具体地涉及包含其的多嵌段共聚物和胶束。
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公开(公告)号：US08779008B2
公开(公告)日：2014-07-15
申请号：US13720189
申请日：2012-12-19
IPC分类号： A61K31/05 , A61K9/19 , A61K47/48 , C12N15/88 , A61K47/34 , C08G69/40 , C08G73/02 , A61K9/107
CPC分类号： A61K47/34 , A61K9/1075 , A61K9/19 , A61K47/551 , A61K47/62 , A61K47/6907 , C08G69/40 , C08G73/028 , C12N15/88
摘要： The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.
摘要翻译： 本发明涉及聚合物化学领域，更具体地涉及包含其的多嵌段共聚物和胶束。
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